Quinidine-catalyzed enantioselective domino Michael addition/cyclization process: Synthesis of chiral 1,4-dihydro-pyridine containing benzosultams

Synthesis of functionalized 1,4-dihydropyridines containing benzosultams catalyzed by lipase

“…11 In 2022, Cheng and co-workers selected quinidine as the catalyst, and good enantioselectivities were obtained (Scheme 1b). 12 In addition, generation methods of 1,4-DHPs containing benzosultams via [3+3] annulation reactions have been developed. Swamy's group reported a procedure establishing fused 1,4-DHPs via DBU-catalyzed (Scheme 1c).…”

Dinuclear zinc catalyzed asymmetric [3 + 2] spiroannulation for the synthesis of diverse bispirocyclic saccharines

“…On the other hand, saccharine-derived cyclic 1-azadienes 1 are commonly used as good reactants with double reaction sites in domino [4 + 2] 7 and [2 + 3] 8 reactions for the construction of chiral N-hetero six-membered rings and full carbon or O-hetero five-membered rings (Scheme 1A). However, research on the use of cyclic 1-azadienes 1 as the 1,3-bis(electrophilic) partner in the catalytic asymmetric [3 + n ] reactions is rather underdeveloped.…”