Quinizarin interaction with bile salts micelles as biomimetic model membranes

Abstract

The evaluation of the interaction of quinizarin (Q), an analogue of the core unit of various anticancer drugs, with two bile salts sodium cholate (NaC) and sodium deoxycholate (NaDC) in 0.1 M phosphate buffer (pH 7.4), investigated by absorption and conductance measurements is presented in this work. The values of binding constant (Kb), partition coefficient (Kx) and free energy change (ΔG) were determined and discussed in terms of possible intermolecular interactions. The results indicate higher binding constant and partition coefficient values for NaDC micelles than NaC micelles and this distinct interaction of quinizarin with NaTDC and NaTC micelles is supported by the differences in nature and structure of bile salts micelles. The critical micelle concentration (CMC) of both bile salts, determined using electrical conductivity measurements is higher in the presence of quinizarin.

Evaluation of Photodynamic Therapy as a New Therapeutic Approach Using Quinizarin-Loaded Nanocapsules: In Vitro Cytotoxicity, Permeation in 3D Bioprinted Skin Equivalent and In Vitro Cytokines Modulation

“…One of the biggest challenges of PDT is the choice of the most suitable photosensitizer, which essential characteristics such as biological affinity, biodistribution and minimum photodynamic potential for application [15]. Quinizarin, (QZ) (1,4 dihydroxyanthraquinone), an anthraquinone derivative compound, shows secondary biological activities characteristics as anti-inflammatory, antioxidant, antibacterial action [19][20][21], and high potential as photosensitizing compounds [22] showing high-density planar and quinoid conjugated aromatic groups electronics, which may contribute to the generation of reactive oxygen species (ROS), [23][24][25][26], with a high potential as photosensitizing compounds from a PDT perspective [22].…”