Quinolizidine alkaloids isolated from Lupinus species enhance insulin secretion

López, Pedro Macedonio García; Mora, P. Garzón de la; Wysocka, Waleria; Maiztegui, Bárbara; Alzugaray, María Eugenia; Zotto, H Del; Borelli, María Inés

doi:10.1016/j.ejphar.2004.09.008

Cited by 85 publications

(36 citation statements)

References 13 publications

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“…A clear example is diabetes, where it is believed that it may provoke early satiety and consequently reduces caloric intake and glycemic values [8][9][10]. In addition, it has been used for musculoskeletal pain and for prevention purposes like cancer and cardiovascular diseases, because of its isoflavonoid content [11].…”

Section: Introductionmentioning

confidence: 99%

Pupillary Disorders in the Emergency Room: Lupinus mutabilis Intoxication

Alessandro¹,

Wibecan²,

Cammarota³

et al. 2017

J Clinic Toxicol

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Lupinus mutabilis (LM) is a widespread species of lupin whose bean is consumed not only for its high caloric value but also as a homeopathic medicine, used for a diverse range of presumed clinical properties, including as an analgesic and an antidiabetic. The properties of lupine alkaloids are responsible for their anticholinergic toxicity in both the autonomic nervous system and the central nervous system (CNS). As this syndrome may vary in severity, lupinus toxicity should be suspected in patients with isolated symptoms as well, such as hyporeactive mydriasis.We present a case of a 48-year-old male patient presented to emergency department complaining about blurred vision, dizziness and palpitations. Physical examination only reveal hyporeactive mydriasis. Urine drug screening was negative and labs were otherwise within normal ranges. Brain Computed Tomography did not identify any abnormality. During the examination patient admitted that he was taking homeopathic medication for his osteoarthritis pain that contains high amounts of LM. He received hydration with parenteral saline while maintaining an adequate diuretic rhythm. Twelve hours later, his mydriasis had completely resolved. Clinicians should consider the possibility of LM toxicity in cases of pupillary abnormalities without any clear alternative explanation.

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Section: Introductionmentioning

confidence: 99%

Pupillary Disorders in the Emergency Room: Lupinus mutabilis Intoxication

Alessandro¹,

Wibecan²,

Cammarota³

et al. 2017

J Clinic Toxicol

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“…Our choice was 13a-hydroxy-2-thionosparteine (7). Direct thionation of the lactam group in 13a-hydroxylupanine (4) failed.…”

Section: Introductionmentioning

confidence: 99%

“…The compounds of plant origin which demonstrate the hypoglycemic activity include alkaloids occurring in plants of the Fabaceae family [2][3][4][5]. There are reports on sparteine (1) sulfate [5] and lupanine (2) [6] as well as lupanine, 17-oxolupanine (3), 13a-hydroxylupanine (4) and 2-thionosparteine (5) as the compounds increasing insulin secretion or decreasing the level of glucose in the blood [7]. According to Murakoshi et al [8], the alkaloid showing the highest hypoglycemic activity (from among several quinolizidine compounds) when administered to mice with streptozotocin-induced diabetes was multiflorine (6).…”

Section: Introductionmentioning

confidence: 99%

The spatial structure of 13α-hydroxy-2-thionosparteine – a potential hypoglycemic agent – and some related compounds

Brukwicki

Włodarczak

Wysocka

2009

Journal of Molecular Structure

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“…1. Recently 2-thionosparteine was found to have a better hypoglycemic effect than glibenclamide, one of the compounds used in treatment of diabetes [4,5].…”

Section: Introductionmentioning

confidence: 99%