Quinolone resistance in the food chain

Fàbrega, Anna; Sánchez‐Céspedes, Javier; Soto, Sara M.; Vila, Jordi

doi:10.1016/j.ijantimicag.2007.12.010

Cited by 104 publications

(79 citation statements)

References 79 publications

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“…The positive effect of antibiotics on growth was first discovered in the early 1940s, when it was found that dried mycelia of Streptomyces aureofaciens containing chlortetracycline residues improved overall growth of subjected animals. Antimicrobial agents could be used and as feed additives as well as with drinking water for not only therapeutic but also prophylactic purposes (Fabrega et al, 2008). Commonly, antibiotics promote growth by interacting with intestinal microbial population and stimulating feed intake (Dibner and Richards, 2005).…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of body weight and serum biochemistry in broilers supplemented with some selected probiotics and antibiotic growth promoters

2017

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Objective: The present work was conducted on Cobb-500 broilers fed with either probiotics (Yogurt, Promax ® ) or antibiotic growth promoters (Ciproflox ® , Renamycin ® ) to assess the effects on body weight and biochemical parameters. Materials and methods: A total of 30 day-old broiler chicks were purchased and acclimatized for 7 days in the experimental shed. After initial acclimatization, the broilers were allotted into five equal groups (n=6). Group A was considered as control and was fed commercial ration and fresh drinking water. Groups B and C were fed commercial ration and probiotics (Yogurt, Promax ® ) respectively mixed in water. Groups D and E received commercial ration and antibiotic growth promoters (Ciproflox ® , Renamycin ® ) respectively with water. Body weight of each bird was recorded on day 7, 14, 21, 28 and 35. At the end of trial period, the birds were sacrificed to collect blood in order to prepare serum samples for biochemical analyses considering total cholesterol, triglyceride, high density lipids (HDL), creatinine, alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Results: Body weight in all treatment groups (B, C, D and E) was significantly (P<0.05) higher as compared to control (A) group. Total cholesterol and triglyceride levels significantly (P<0.05) decreased in probiotics treated groups as compared to control and antibiotic growth promoters treated groups. AST and ALT values increased significantly (P<0.05) in antibiotic growth promoters treated groups as compared to control whereas, these values decreased in probiotics treated groups. Creatinine levels were significantly (P<0.05) higher in antibiotic growth promoters treated groups as compared to all others groups. Conclusion: Significantly increased body weight is observed in probiotics and antibiotic growth promoters supplemented broilers. Probiotics also improve the lipid profile and other biochemical parameters as compared to growth promoter. Probiotics (like Yogurt and Promax ® ) seem to be better choice than antibiotic growth promoters as feed supplements.

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Section: Introductionmentioning

confidence: 99%

Comparative analysis of body weight and serum biochemistry in broilers supplemented with some selected probiotics and antibiotic growth promoters

2017

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“…These organisms could serve as a reservoir for the genes encoding antimicrobial resistance, which is transferred to the pathogenic bacteria or transmitted to the human by direct exposure to animals or via the food chain. [15][16][17][18][19] It has been shown that the resistant bacteria with animal origin can either colonize or cause infection in humans.…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic Grouping and Phenotypic Detection of Extended-Spectrum β-Lactamases Among Escherichia coli From Calves and Dairy Cows in Khuzestan, Iran

Barzan¹,

Gharibi²,

Ghorbanpoor³

et al. 2017

Int J Enteric Pathog

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Background: Food-producing animals are under suspicion for the reservoir and colonization of ESBL (extended-spectrum beta-lactamase)-producing bacteria especially Enterobacteriaceae and therefore infection of the humans with them. The increasing reports on the ESBLs presence in the pathogenic and commensal Escherichia coli isolates have been a concern worldwide. These strains can be attributed to one of the main phylogenetic groups and subgroups. Several studies have shown the relationship between the phylogeny and antimicrobial resistance of E. coli strains. Objectives: The aim of this study was to analyze the phylogenetic group of ESBL-producing E. coli and detect its phenotype using the multiplex polymerase chain reaction (PCR) and combined disk method. Materials and Methods: Two hundred five E. coli fecal isolates were obtained from 103 calves (90 healthy and 13 diarrheic) and 102 dairy cows (healthy) from 8 farms in Khuzestan province, Iran. The triplex PCR method was used to allocate the E. coli isolates based on the presence or absence of 3 genes (chuA, yjaA, and tspE4.C2) to yield 4 definite phylogenetic groups and 7 subgroups. Phenotypic ESBL-producing E. coli was determined using the double disk diffusion method according to the manufacturer's instructions and Clinical & Laboratory Standards Institute (CLSI) guidelines. Results: A total of 65.04% and 22.3% of isolates from calves and 70.5% and 20.5% of isolates from dairy cows belonged to phylogroups B1 and A, respectively. In addition, no isolate from the diarrhoeic calves was found to belong to group B2 and subgroups D2 and A0. A low prevalence (2/205 isolates, 0.97%) of ESBL-producing E. coli was found only in the samples of dairy cows which belonged to the phylogenetic group A and phylogenetic subgroup A1. There was no statistically significant relationship between the phylogenetic group and the production of ESBLs (P = 0.11). There was also no difference between the E. coli isolates from calves and dairy cows in the production of ESBLs (P = 0.5). Conclusion: There was no statistically significant relationship between the phylogenetic group and the production of ESBLs (P = 0.11). There was also no difference between E. coli isolates from calves and dairy cows in the production of ESBLs (P = 0.5). Based on these results, there is a low prevalence of ESBL-producing E. coli in the dairy farms of Khuzestan province. However, further large scale investigations are necessary to control the antibiotic resistance in the human and animal foodstuff.

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“…Milk is widely consumed globally and can contain antibiotics or their residues if the animals that produced it had been treated with the drugs. These residues might have direct toxic effects on consumers through allergic reactions or they may cause indirect problems by promoting bacterial resistance [2,3]. Thus, the use of antibiotics has become an increasingly important public health concern.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of the LC–MS/MS and UPLC–MS/MS for the multi-residue analysis of quinolones, penicillins and cephalosporins in cow milk, and validation according to the regulation 2002/657/EC

Junza

Amatya

Barrón

et al. 2011

Journal of Chromatography B

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The aim of this study was to develop and validate an analytical method to simultaneously determine European Union-regulated ȕ-lactams (penicillins and cephalosporins) and quinolones in cow milk. The procedure involves a new solid phase extraction (SPE) to clean-up and pre-concentrate the three series of antibiotics before analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). LC-MS/MS and UPLC-MS

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Quinolone resistance in the food chain

Cited by 104 publications

References 79 publications

Comparative analysis of body weight and serum biochemistry in broilers supplemented with some selected probiotics and antibiotic growth promoters

Comparative analysis of body weight and serum biochemistry in broilers supplemented with some selected probiotics and antibiotic growth promoters

Phylogenetic Grouping and Phenotypic Detection of Extended-Spectrum β-Lactamases Among Escherichia coli From Calves and Dairy Cows in Khuzestan, Iran

Comparative study of the LC–MS/MS and UPLC–MS/MS for the multi-residue analysis of quinolones, penicillins and cephalosporins in cow milk, and validation according to the regulation 2002/657/EC

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