Quinone Analogue Irrecoverably Paralyses the Filarial Parasitesin Vitro

Sivan, V.M.; Raj, Rishi

doi:10.1006/bbrc.1998.9988

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Oxidative and Respiratory Metabolism1

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Cited by 2 publications

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“…The presence of Q 8 in ES materials may be a parasite adaptation for its comfortable coexistence within the host system. Stimulation of lipid peroxidation observed in the presence of Q 0 further supports the earlier findings from our laboratory that unlike the higher members, lower ubiquinone analogues are useful as effective antifilarial substances (16,35).…”

Section: Discussionsupporting

confidence: 88%

The Adult-Specific Ubiquinone Q8 Functions as an Antioxidant in the Filarial Parasite, Setaria digitata

Mohan

Pradeep

Kumar

et al. 2001

Biochemical and Biophysical Research Communications

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Section: Discussionsupporting

confidence: 88%

The Adult-Specific Ubiquinone Q8 Functions as an Antioxidant in the Filarial Parasite, Setaria digitata

Mohan

Pradeep

Kumar

et al. 2001

Biochemical and Biophysical Research Communications

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“…digitata . Thus, an analogue of quinone can inactivate the filarial parasites and may prove to be an effective drug to control filariasis (Sivan & Raj, 1992, 1999).…”

Section: Oxidative and Respiratory Metabolismmentioning

confidence: 99%

Biochemical composition and metabolic pathways of filarial worms Setaria cervi: search for new antifilarial agents

Ahmad

Srivastava

2007

J. Helminthol.

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The main problem regarding the chemotherapy of filariasis is that no safe and effective drug is available yet to combat the adult human filarial worms. Setaria cervi, the causal organism of setariasis and lumbar paralysis in cattle, is routinely employed as a model organism for conducting biochemical and enzymatic studies on filarial parasites. In view of the practical difficulties in procuring human strains of Wuchereria bancrofti and Brugia malayi for drug screening, the bovine filarial parasite S. cervi, resembling the human species in having microfilarial periodicity and chemotherapeutic response to known antifilarial agents, is widely used as a model in such studies. For a rational approach to antifilarial chemotherapy, knowledge of the biochemical composition and metabolic pathways of this helminth parasite may be of paramount importance, so that more potent antifilarial agents based on specific drug targets can be identified in drug discovery programmes. The present review provides an update on the biochemistry of the important metabolic pathways functioning within this potentially important bovine parasite, that have so far been studied, and on those that need to be investigated further so as to identify novel drug targets that can be exploited for designing new antifilarial drugs.

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Quinone Analogue Irrecoverably Paralyses the Filarial Parasitesin Vitro

Cited by 2 publications

References 9 publications

The Adult-Specific Ubiquinone Q8 Functions as an Antioxidant in the Filarial Parasite, Setaria digitata

The Adult-Specific Ubiquinone Q8 Functions as an Antioxidant in the Filarial Parasite, Setaria digitata

Biochemical composition and metabolic pathways of filarial worms Setaria cervi: search for new antifilarial agents

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