Quinones from plants of northeastern Brazil: structural diversity, chemical transformations, NMR data and biological activities

Lemos, Telma L. G.; Monte, Francisco José Queiroz; Santos, Allana Kellen L.; Fonseca, Aluísio Marques da; Santos, Hélcio Silva dos; Oliveira, Mailcar F.; Costa, Sônia M. O.; Pessoa, Otília Deusdênia Loiola; Braz-Filho, Raimundo

doi:10.1080/14786410601130604

Cited by 26 publications

(15 citation statements)

References 36 publications

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“…(Rodrigues & de Carvalho, 2001) and L. sidoides Cham. (Lemos et al, 2007). In this study, the influence of EERLlup, EELLsal and EESLsal, together with their partition fractions, was investigated against opportunistic human yeast pathogens (C. albicans, C. krusei, C. parapsilosis and C. neoformans).…”

Section: Antifungal Assaymentioning

confidence: 99%

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Chemical and antifungal investigations of six Lippia species (Verbenaceae) from Brazil

et al. 2012

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The Lippia genus is used in ethnobotany as food, beverages, seasoning and antiseptic remedies, among others. The chemical compositions of fifteen extracts of six Lippia species were investigated comparatively by HPLC-PDA. To avoid data replication of previous works on this genus, Lippia lupulina Cham. root ethanol extract was selected for isolation procedures based on Principal Component Analyses (PCA) of such data. Seven compounds previously unreported in this genus were isolated from this extract (a triterpene, two furanonaphtoquinones, a furanochromone, an isoflavone, a stilbene and an iridoid). The activities of extracts, fractions and pure compounds towards Candida albicans, Candida krusei, Candida parapsilosis and Cryptococcus neoformans were investigated. Two fractions from the extract of Lippia salviaefolia leaves showed marked inhibition of fungal growth, in addition to verbascoside and asebogenin, which showed MICs lower than 15.6μg/ml and may be promising leads for the development of new antifungal agents, especially against C. neoformans.

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Section: Antifungal Assaymentioning

confidence: 99%

“…Lippia sidoides Cham., also investigated in the present work, has been widely used in Northeastern Brazil as a general use antiseptic (Lemos et al, 2007). Dried and milled leaves, flowers and fruits of this plant have been used as a substitute for Thymus vulgaris in spice mixtures for pizzas and meats (Lorenzi & Matos, 2002).…”

Section: Introductionmentioning

confidence: 98%

Chemical and antifungal investigations of six Lippia species (Verbenaceae) from Brazil

et al. 2012

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“…Lapachol i jego pochodne są typowe dla roślin z rodziny Bignoniaceae (Tabebuia aurea, Tabebuia impetiginosa, Tabebuia ochracea). Naftochinony nie tylko wyizolowano, określono ich strukturę chemiczną, ale też opracowano metody ich syntezy [45]. W latach 2004-2005 Japończycy wyizolowali serię glikozydów (irydoidów, lignanów, flawonoidów) [46,47].…”

Section: Fitochemiaunclassified

Zioła peruwiańskie w Europie

Paradowska

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2015

HERB

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Przyroda Ameryki Południowej, w tym Peru, to prawdziwa naturalna apteka; uważa się, że ponad 80% rosnących tu roślin ma właściwości lecznicze. Rejonem Andów i dorzeczem Amazonki interesują się zarówno firmy farmaceutyczne jak i ośrodki akademickie na całym świecie. Kilka roślin tego regionu zdobyło już rozgłos w Europie, należą do nich: Cat's claw (Uncaria tomentosa), Maca (Lepidium meyenii) czy Dragon's blood (Croton lechleri). Każda z nich ma bardzo długą tradycję stosowania przez Indian w Ameryce Południowej. Jednak popularyzacja tych roślin jako surowców farmaceutycznych czy też roślin uzupełniających dietę mieszkańców Europy wymaga przeprowadzenia badań fitochemicznych, biologicznych oraz farmakologicznych.

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“…The chemistry of oximes derived from lapachol and lapachones has been studied by several groups because these substances show important biologic and organic chemical applications [1,2,3,4]. α-Lapachone (2,2-dimethyl-3,4-dihydro-2 H -benzo[ g ]chromene-5,10-dione) is a natural naphtha-quinone found in the wood of trees of the genus Tabebuia (family Bignoniaceae ), which occur in most of Central and South Americas and are known as ipê or pau d’arco in Brazil (e.g., ipê-roxo, Tabebuia serratifolia ) and lapacho in Argentina and other Spanish-speaking countries.…”

Section: Introductionmentioning

confidence: 99%

Crystal Structure and Hydrogen Bonding Study of (10E)-2,2-Dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione 10-Oxime Derived From a-Lapachone

et al. 2011

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Abstract:The compound (10E)-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione-10-oxime (1) was synthesized from α-lapachone and hydroxylamine chloride in alkaline medium. Single-crystals suitable for X-ray diffraction measurements were grown from an ethanol solution, and the crystal structure of the title molecule is reported for the first time. The title molecule was also characterized by 1 H-and 13 C-NMR in CDCl 3 solution, FTIR and MS. The crystal structure of 1 shows an E stereochemistry and dimers formed through classical hydrogen bonds.

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Quinones from plants of northeastern Brazil: structural diversity, chemical transformations, NMR data and biological activities

Cited by 26 publications

References 36 publications

Chemical and antifungal investigations of six Lippia species (Verbenaceae) from Brazil

Chemical and antifungal investigations of six Lippia species (Verbenaceae) from Brazil

Zioła peruwiańskie w Europie

Crystal Structure and Hydrogen Bonding Study of (10E)-2,2-Dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione 10-Oxime Derived From a-Lapachone

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