Chemical and antifungal investigations of six Lippia species (Verbenaceae) from Brazil

Funari, Cristiano Soleo; Gullo, Fernanda Patrícia; Napolitano, Assunta; Carneiro, Renato Lajarim; Mendes-Giannini, María José Soares; Fusco‐Almeida, Ana Marisa; Piacente, Sonia; Pìzza, Cosimo; Silva, Dulce Helena Siqueira

doi:10.1016/j.foodchem.2012.06.077

Cited by 42 publications

(16 citation statements)

References 25 publications

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“…Major secondary metabolite parietin isolated from Xanthoria parietina L. lichen cultures has shown strong antibacterial activity against a wide range of bacterial strains, first of all, against Staphylococcus aureus , and antifungal effects against Rhizoctonia solani , in particular [157]. Recent studies of seven compounds isolated from Lippia species have confirmed very high anti- Cryptococcus neoformans activity of verbascoside, interpreted by the authors as a promising way for new selective anti-fungal verbascoside-containing topical drugs [158]. …”

Section: Universal Protection Provided By Secondary Plant Metabolimentioning

confidence: 99%

Meristem Plant Cells as a Sustainable Source of Redox Actives for Skin Rejuvenation

Korkina¹,

Mayer²,

Luca³

2017

Biomolecules

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Recently, aggressive advertisement claimed a “magic role” for plant stem cells in human skin rejuvenation. This review aims to shed light on the scientific background suggesting feasibility of using plant cells as a basis of anti-age cosmetics. When meristem cell cultures obtained from medicinal plants are exposed to appropriate elicitors/stressors (ultraviolet, ultrasound ultraviolet (UV), ultrasonic waves, microbial/insect metabolites, heavy metals, organic toxins, nutrient deprivation, etc.), a protective/adaptive response initiates the biosynthesis of secondary metabolites. Highly bioavailable and biocompatible to human cells, low-molecular weight plant secondary metabolites share structural/functional similarities with human non-protein regulatory hormones, neurotransmitters, pigments, polyamines, amino-/fatty acids. Their redox-regulated biosynthesis triggers in turn plant cell antioxidant and detoxification molecular mechanisms resembling human cell pathways. Easily isolated in relatively large quantities from contaminant-free cell cultures, plant metabolites target skin ageing mechanisms, above all redox imbalance. Perfect modulators of cutaneous oxidative state via direct/indirect antioxidant action, free radical scavenging, UV protection, and transition-metal chelation, they are ideal candidates to restore photochemical/redox/immune/metabolic barriers, gradually deteriorating in the ageing skin. The industrial production of plant meristem cell metabolites is toxicologically and ecologically sustainable for fully “biological” anti-age cosmetics.

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Section: Universal Protection Provided By Secondary Plant Metabolimentioning

confidence: 99%

Meristem Plant Cells as a Sustainable Source of Redox Actives for Skin Rejuvenation

Korkina¹,

Mayer²,

Luca³

2017

Biomolecules

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“…Based on spectroscopic data and by comparison to previously reported compounds, Compounds 3 – 37 were identified as: scopoletin ( 3 ) [18], naringenin ( 4 ) [19], p -hydroxybenzoic acid ( 5 ) [20], pyrogallol ( 6 ) [21], protocatechuic acid ( 7 ) [22], taxifolin ( 8 ) [23], aromadendrin ( 9 ) [24], eriodictyol ( 10 ) [25], mearnsetin ( 11 ) [26], luteolin ( 12 ) [27], fraxetin ( 13 ) [28], naringenin 5- O -β- d -glucopyranoside ( 14 ) [29], methyl 4-hydroxylbenzoate ( 15 ) [30], (−)-salipurposide ( 16 ) [31], naringenin 4′- O -β- d -glucopyranoside ( 17 ) [32], (+)-catechin ( 18 ) [33], epicatechin ( 19 ) [34], quercetin ( 20 ) [34], eriodictyol 4′- O -β- d -glucopyranoside ( 21 ) [35], tricetin ( 22 ) [36], (2 S )-eriodictyol 7- O -β- d -glucopyranoside ( 23 ) [37], (2 R )-eriodictyol 7- O -β-glucopyranoside ( 24 ) [38], gallic acid ( 25 ) [39], gallocatechin ( 26 ) [40], kaempferol 3- O -rutinoside ( 27 ) [41], isorhamnetin 3- O -rutinoside ( 28 ) [42], isoquercitrin ( 29 ) [43], quercitrin ( 30 ) [44], 2α,3α-epoxy-5,7,3′,4′-tetrahydroxyflavan-(4β-8-catechin) ( 31 ) [45], proanthocyanidin A2 ( 32 ) [46], isomericitrin ( 33 ) [47], quercimetrin ( 34 ) [48], rutin ( 35 ) [34], myricetrin ( 36 ) [44], and myricetin 3- O -rutinoside ( 37 ) [49].…”

Section: Resultsmentioning

confidence: 99%

Polyphenols Isolated from Xanthoceras sorbifolia Husks and Their Anti-Tumor and Radical-Scavenging Activities

Yang

Lin

et al. 2016

Molecules

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Xanthoceras sorbifolia Bunge. is used in traditional medicine in North China. To evaluate the anti-tumor and radical-scavenging activities of X. sorbifolia husks polyphenols and determine their structure-activity relationships, 37 polyphenols 1-37 were obtained by bioassay-guided fractionation. Two new compounds 1-2, and compounds 5, 6, 8, 9, 11, 14-17, 21-25, 27-29, 31, 33, 34, 36, and 37 were isolated from the genus Xanthoceras for the first time. Compounds 1-37 did not show strong cytotoxicity against the four tested tumor cell lines (A549, HepG2, MGC-803, and MFC) compared to paclitaxel and under the conditions tested in the anti-tumor assay, but compounds 3, 4, 7, 8, 10, 18-20, 25, 26, 29, 30, 32, and 35 exhibited stronger radical-scavenging activity than ascorbic acid in a 2,2 -azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt assay. This was the first report on the anti-tumor and radical-scavenging activities of the polyphenols isolated from X. sorbifolia husks. Overall, the present study contributed valuable information concerning X. sorbifolia husks use in medicine and pharmacology.

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“…Lippia sidoides is an aromatic bush of the Verbenaceae family, typically found in the Northeast region of Brazil (semiarid climate), where it is popularly known as “pepper-rosmarin”, and available at a low cost 17 , 18 . However, the literature points to its occurrence in many countries in the American continent, such as Mexico, Guatemala, Cuba, Guyana, Venezuela, and Colombia 19 .…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review of the Potential Effects of Lippia sidoides on Dental Plaque and Periodontal Diseases

et al. 2021

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Lippia sidoides is a typical shrub from Brazil that has been used in traditional medicine. This is a systematic review on the effect of L. sidoides for controlling dental plaque, gingivitis, and periodontitis. A database search through May 2021 in Medline/PubMed, SCOPUS, BVS, and Web of Science identified 711 reports of which 17 met our inclusion criteria. Five randomized controlled trials and three animal studies were included that compared L. sidoides-based products (toothpaste, mouthrinse, and gel) to cetylpyridinium chloride, chlorhexidine, and placebo products. Among the human studies, a significant antiplaque effect after treatment with L. sidoides-based products was observed in three studies and an antigingivitis effect in two studies, similar to chlorhexidine-based products. One study found superior dental plaque reduction compared to cetylpyridinium chloride mouthrinse. Only one study testing a L. sidoides gel found no antiplaque effect. Among the animal studies, an L. sidoides mouthrinse significantly reduced calculus in two studies, inflammatory infiltrate in one study, and plaque bacteria and gingivitis in one study. An L. sidoides gel significantly reduced alveolar bone loss and inflammatory response in one study in which mice were submitted to ligature-induced periodontal disease. In general, L. sidoides-based products were effective in reducing dental plaque and calculus formation, as well as clinical signs of gingivitis. As most studies present methodological limitations, these results should be interpreted carefully. Further clinical trials with greater methodological accuracy and control of biases are necessary for the use of L. sidoides-based products in humans to be viable in clinical practice.

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Chemical and antifungal investigations of six Lippia species (Verbenaceae) from Brazil

Cited by 42 publications

References 25 publications

Meristem Plant Cells as a Sustainable Source of Redox Actives for Skin Rejuvenation

Meristem Plant Cells as a Sustainable Source of Redox Actives for Skin Rejuvenation

Polyphenols Isolated from Xanthoceras sorbifolia Husks and Their Anti-Tumor and Radical-Scavenging Activities

A Systematic Review of the Potential Effects of Lippia sidoides on Dental Plaque and Periodontal Diseases

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