Quorum sensing inhibitors: a patent review (2014–2018)

Chen, Xin; Zhang, Likun; Zhang, Mingxiang; Liu, Huayu; Lu, Panrui; Lin, Kejiang

doi:10.1080/13543776.2018.1541174

Cited by 56 publications

(33 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to the promise offered by quorum sensing inhibition, it is not surprising that a variety of small-molecules (synthetic as well as natural products) with signicant antiquorum sensing and antibiolm activities in Gram-negative and Gram-positive bacteria have been reported. [21][22][23][24] Literature is full of reports particularly on quorum sensing inhibition in Pseudomonas aeruginosa. [25][26][27][28][29][30][31][32][33][34][35][36] Carvacrol (essential oil) was reported to inhibit biolm formation in S. aureus and P. aeruginosa and pyocyanin production in P. aeruginosa signicantly.…”

Section: Introductionmentioning

confidence: 99%

Potassium 2-methoxy-4-vinylphenolate: a novel hit exhibiting quorum-sensing inhibition inPseudomonas aeruginosa viaLasIR/RhlIR circuitry

et al. 2019

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Potassium 2-methoxy-4-vinylphenolate: a novel hit exhibiting quorum-sensing inhibition inPseudomonas aeruginosa viaLasIR/RhlIR circuitry

et al. 2019

View full text Add to dashboard Cite

show abstract

“…QS inhibition mechanisms have been reported to boast numerous biotechnological applications, which have become of great interest as alternative to other treatments. In the last decades, QQ and QSI approaches have been tested in aquaculture, agriculture, wastewater treatment, medicine and food packaging, amongst others, as reflected by the increasing number of patents within the field (reviews: [88,271,272]).…”

Section: Applications In Aquaculture and Other Industriesmentioning

confidence: 99%

“…In the aquaculture sector, different studies have proved the potential value of QQ to fight bacterial infections by incorporating the AHL-degrading bacteria or QQ enzymes in the rearing water or by bioencapsulating them in the feed stock [47,104,125,133,273,274,275]. Here also, several patent applications have been registered (reviews: [88,271,272]). To date, the use of AHL-degrading marine bacteria and their purified QQ enzymes has proved to be successful in reducing or eliminating the virulence of pathogenic bacteria against fish, crustaceans, mollusks, and corals.…”

Section: Applications In Aquaculture and Other Industriesmentioning

confidence: 99%

Saline Environments as a Source of Potential Quorum Sensing Disruptors to Control Bacterial Infections: A Review

2019

View full text Add to dashboard Cite

Saline environments, such as marine and hypersaline habitats, are widely distributed around the world. They include sea waters, saline lakes, solar salterns, or hypersaline soils. The bacteria that live in these habitats produce and develop unique bioactive molecules and physiological pathways to cope with the stress conditions generated by these environments. They have been described to produce compounds with properties that differ from those found in non-saline habitats. In the last decades, the ability to disrupt quorum-sensing (QS) intercellular communication systems has been identified in many marine organisms, including bacteria. The two main mechanisms of QS interference, i.e., quorum sensing inhibition (QSI) and quorum quenching (QQ), appear to be a more frequent phenomenon in marine aquatic environments than in soils. However, data concerning bacteria from hypersaline habitats is scarce. Salt-tolerant QSI compounds and QQ enzymes may be of interest to interfere with QS-regulated bacterial functions, including virulence, in sectors such as aquaculture or agriculture where salinity is a serious environmental issue. This review provides a global overview of the main works related to QS interruption in saline environments as well as the derived biotechnological applications.

show abstract

“…QS inhibitors (QSIs) do not kill bacteria, and therefore, exert minimum selective pressure on bacteria to develop AMR. Furthermore, QSIs can be used as a combination therapy with conventional antibiotics to give synergistic effects, particularly when the infection is caused by resistant bacteria [ 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis and Biological Evaluation of Novel Anthraniloyl-AMP Mimics as PQS Biosynthesis Inhibitors Against Pseudomonas aeruginosa Resistance

et al. 2020

View full text Add to dashboard Cite

The Pseudomonas quinolone system (PQS) is one of the three major interconnected quorum sensing signaling systems in Pseudomonas aeruginosa. The virulence factors PQS and HHQ activate the transcription regulator PqsR (MvfR), which controls several activities in bacteria, including biofilm formation and upregulation of PQS biosynthesis. The enzyme anthraniloyl-CoA synthetase (PqsA) catalyzes the first and critical step in the biosynthesis of quinolones; therefore, it is an attractive target for the development of anti-virulence therapeutics against Pseudomonas resistance. Herein, we report the design and synthesis of novel triazole nucleoside-based anthraniloyl- adenosine monophosphate (AMP) mimics. These analogues had a major impact on the morphology of bacterial biofilms and caused significant reduction in bacterial aggregation and population density. However, the compounds showed only limited inhibition of PQS and did not exhibit any effect on pyocyanin production.

show abstract

Quorum sensing inhibitors: a patent review (2014–2018)

Cited by 56 publications

References 41 publications

Potassium 2-methoxy-4-vinylphenolate: a novel hit exhibiting quorum-sensing inhibition inPseudomonas aeruginosa viaLasIR/RhlIR circuitry

Potassium 2-methoxy-4-vinylphenolate: a novel hit exhibiting quorum-sensing inhibition inPseudomonas aeruginosa viaLasIR/RhlIR circuitry

Saline Environments as a Source of Potential Quorum Sensing Disruptors to Control Bacterial Infections: A Review

Design, Synthesis and Biological Evaluation of Novel Anthraniloyl-AMP Mimics as PQS Biosynthesis Inhibitors Against Pseudomonas aeruginosa Resistance

Contact Info

Product

Resources

About