Background: Some factors can act on nutritional status of patients operated for a
gastrointestinal cancer. A timely and appropriate nutritional intervention
could have a positive effect on postoperative outcomes. Aim: To determine the effect of a program of intestinal rehabilitation and early
postoperative enteral nutrition on complications and clinical outcomes of
patients underwent gastrointestinal surgery for cancer. Methods: This is a prospective study of 465 patients underwent gastrointestinal
surgery for cancer consecutively admitted in an oncological intensive care
unit. The program of intestinal rehabilitation and early postoperative
enteral nutrition consisted in: 1) general rules, and 2) gastrointestinal
rules. Results: The mean age of analysed patients was 63.7±9.1 years. The most frequent
operation sites were colon-rectum (44.9%), gynaecological with intestinal
suture (15.7%) and oesophagus-gastric (11.0%). Emergency intervention was
performed in 12.7% of patients. The program of intestinal rehabilitation and
early postoperative enteral nutrition reduced major complication (19.2% vs.
10.2%; p=0.030), respiratory complications (p=0.040), delirium (p=0.032),
infectious complications (p=0.047) and gastrointestinal complications
(p<0.001), mainly anastomotic leakage (p=0.033). The oncological
intensive care unit mortality (p=0.018), length of oncological intensive
care unit (p<0.001) and hospital (p<0.001) stay were reduced as well.
Conclusions: Implementing a program of intestinal rehabilitation and early postoperative
enteral nutrition is associated with reduction in postoperative
complications and improvement of clinical outcomes in patients undergoing
gastrointestinal surgery for cancer.