2018
DOI: 10.1080/21541248.2018.1528840
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Rab GTPases take centre stage in understandingEntamoeba histolyticabiology

Abstract: Rab GTPases constitute the largest subgroup in the Ras superfamily of GTPases. It is well established that different Rab GTPases are localized in discrete subcellular localization and regulate the membrane trafficking in nearly all eukaryotic cells. Rab GTPase diversity is often regarded as an expression of vesicular trafficking complexity. The pathogenic amoeba Entamoeba histolytica harbours 91 Rab GTPases which is the highest among the currently available genome sequences from the eukaryotic kingdom. Here, w… Show more

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Cited by 25 publications
(21 citation statements)
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“…as RabA, B, and X (Nakada-Tsukui, Saito-Nakano, Husain, & Nozaki, 2010;Saito-Nakano, Loftus, Hall, & Nozaki, 2005;Verma, Srivastava, & Datta, 2018), suggesting the functional diversification of Rabs in this parasite. Among evolutionarily conserved Rabs in E. histolytica, Rab7 represents the most divergent group.…”
Section: Introductionmentioning
confidence: 96%
See 1 more Smart Citation
“…as RabA, B, and X (Nakada-Tsukui, Saito-Nakano, Husain, & Nozaki, 2010;Saito-Nakano, Loftus, Hall, & Nozaki, 2005;Verma, Srivastava, & Datta, 2018), suggesting the functional diversification of Rabs in this parasite. Among evolutionarily conserved Rabs in E. histolytica, Rab7 represents the most divergent group.…”
Section: Introductionmentioning
confidence: 96%
“…Rab small GTPases are the evolutionally conserved molecular switch that regulates directional and compartment‐specific membrane traffic. E. histolytica shows, despite its unicellularity, an exceptional expansion of Rab proteins encoded by its genome: 104 Rab genes that include 22 conserved Rab subfamilies such as Rab1, 2, 5, 7, 8, 11, and 21, and a number of unique lineage‐specific subfamilies such as RabA, B, and X (Nakada‐Tsukui, Saito‐Nakano, Husain, & Nozaki, 2010; Saito‐Nakano, Loftus, Hall, & Nozaki, 2005; Verma, Srivastava, & Datta, 2018), suggesting the functional diversification of Rabs in this parasite. Among evolutionarily conserved Rabs in E. histolytica , Rab7 represents the most divergent group.…”
Section: Introductionmentioning
confidence: 99%
“…It infects around 50 million people worldwide and provokes approximately 100,000 deaths per year (W.H.O., ). Amoebiasis is the third most common cause of death due to parasitic diseases, after malaria and schistosomiasis (Gunther, Shafir, Bristow, & Sorvillo, ; Verma, Srivastava, & Datta, ). This parasite has two phases in its life cycle: the cysts, the infective and resistant form, and the trophozoites, the invasive form.…”
Section: Introductionmentioning
confidence: 99%
“…They are molecular switches that present conformational changes associated with the GTP/GDP‐binding cycle. Active Rab‐GTP joins to effector proteins, whereas, inactive Rab‐GDP has low affinity for they (Kotyada et al, ; Verma et al, ).…”
Section: Introductionmentioning
confidence: 99%
“…In fact, the interaction of EhCaBP3 with EhARPC2 contributes to the recruitment of myosin 1B to the phagocytic machinery, promoting the closure of cups and formation of phagosomes [124]. Additional actin regulators contributing to phagocytosis are small GTPases [125], which also participate in other endocytosis processes, and during invasion [114,125]. E. histolytica ras-associated binding protein (EhRab)A interacts with calreticulin and inhibit erythrophagocytosis [126].…”
Section: Entamoeba Histolyticamentioning
confidence: 99%