“…Rab small GTPases are the evolutionally conserved molecular switch that regulates directional and compartment‐specific membrane traffic. E. histolytica shows, despite its unicellularity, an exceptional expansion of Rab proteins encoded by its genome: 104 Rab genes that include 22 conserved Rab subfamilies such as Rab1, 2, 5, 7, 8, 11, and 21, and a number of unique lineage‐specific subfamilies such as RabA, B, and X (Nakada‐Tsukui, Saito‐Nakano, Husain, & Nozaki, 2010; Saito‐Nakano, Loftus, Hall, & Nozaki, 2005; Verma, Srivastava, & Datta, 2018), suggesting the functional diversification of Rabs in this parasite. Among evolutionarily conserved Rabs in E. histolytica , Rab7 represents the most divergent group.…”