RAB13 as a novel prognosis marker promotes proliferation and chemotherapeutic resistance in gastric cancer

Chen, Peng; Chen, Guofu; Wang, Changbiao; Mao, Chenyang

doi:10.1016/j.bbrc.2019.08.141

Cited by 16 publications

(13 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, we conclude that miR-2276-5p is likely to target RAB13 and inhibit glioma cell growth. In published literature, miR-2276-5p has been reported dysregulated in breast cancer ( Torkashvand et al, 2016 ) and colorectal cancer ( Chen et al, 2019a ), and the researchers used the predictive tools to suggest a relationship between miR-2276 and PIWIL2. In another report, there was a 4.5-fold high expression of miR-2276 in colorectal cancer cells that were silenced for STAT3.…”

Section: Discussionmentioning

confidence: 99%

“…Although miR-2276-5p is rarely reported in glioma, wherein it exists as an endogenous competitive RNA impacting glioma cells ( Wang Z. et al, 2019 ), there has been no report on its possible evaluation as a potential biomarker in the exosomes for the diagnosis (or prognosis) of glioma patients. Furthermore, RAB13 has been reported as a novel biomarker in cancer ( Chen et al, 2019a ) with its expression correlating negatively with gastric cancer patients’ overall survival (OS) and progression-free survival (PFS). However, the role, if any, of RAB13 in glioma is unclear.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Exosomal miR-2276-5p in Plasma Is a Potential Diagnostic and Prognostic Biomarker in Glioma

Sun

Gareev

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

IntroductionExosomal microRNAs (miRNAs) play an essential role in near and distant intercellular communication and are potential diagnostic and prognostic biomarkers for various cancers. This study focused on evaluation of exosomal miR-2276-5p in plasma as a diagnostic and prognostic biomarker for glioma.MethodsPlasma exosomes from 124 patients with glioma and 36 non-tumor controls were collected and subjected to quantitative real-time polymerase chain reaction (qRT-PCR) analysis for the exosomal miR-2276-5p expression. Bioinformatic analyses were performed to identify a gene target, and CGGA and TCGA databases were checked for evaluation of prognostic relevance.ResultsThe exosomal miR-2276-5p in glioma patients had a significantly decreased expression, compared with non-glioma patients (p < 0.01). Receiver operating characteristics (ROC) curve analyses were observed to regulate the diagnostic sensitivity and specificity of miR-2276-5p in glioma; the area under the curve (AUC) for miR-2276-5p was 0.8107. The lower expression of exosomal miR-2276-5p in patients with glioma correlated with poorer survival rates. RAB13 was identified as the target of miR-2276-5p which was high in glioma patients, especially those with higher tumor grades and correlated with poor survival.ConclusionThe circulating exosomal miR-2276-5p is significantly reduced in the plasma of glioma patients, and thus, it could be a potential biomarker for patients with glioma for diagnostic and/or prognostic purposes.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exosomal miR-2276-5p in Plasma Is a Potential Diagnostic and Prognostic Biomarker in Glioma

Sun

Gareev

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…For instance, Rab13 activation promotes metastasis of epithelial cancers 21. RAB13 enhances proliferation and chemo-resistance of gastric cancer cells 22. However, no study determines the role of RAB13 in OS.…”

Section: Discussionmentioning

confidence: 99%

<p>A Novel lncRNA MYOSLID/miR-1286/RAB13 Axis Plays a Critical Role in Osteosarcoma Progression</p>

Yang

Chen

Lin

2019

CMAR

View full text Add to dashboard Cite

Background: Osteosarcoma (OS) is a quite malignant bone cancer. However, how long noncoding RNA (lncRNA) regulates OS progression remains poorly investigated. The present study aims to illustrate the potential functions of lncRNA MYOSLID in the regulation of OS progression. Methods: The expression of YOSLID, miR-1286 and RAB13 was analyzed by qRT-PCR. Cell proliferation was determined via CCK8 and colony formation assays. Transwell assay was used to examine migration and invasion. The luciferase reporter assay, RNA pulldown and RNA immunoprecipitation (RIP) assays were utilized to detect the interactions among MYOSLID, miR-1286 and RAB13. Results: The expression of MYOSLID was upregulated in OS tissues and cell lines. MYOSLID overexpression predicted poor prognosis in OS patients. MYOSLID knockdown suppressed proliferation, migration and invasion of OS cells. MYOSLID was the sponge for miR-1286 and inhibited its expression while miR-1286 targeted RAB13 directly. MYOSLID promoted RAB13 expression via sponging miR-1286. Conclusion: Our work demonstrated that the MYOSLID/miR-1286/RAB13 axis is a novel regulatory signaling in promoting OS progression.

show abstract

“…Rab8 suppresses pemetrexet effect by regulating the TNFRSF10B transport to the cytoplasm (Wang et al, 2020). Besides, Rab13 affect the sensitization of gastric cancer to 5fluorouracil treatment by regulating the EGFR transport to the cell membrane (Chen et al, 2019). (iv) Rab5a and Rab21 function through recycling multidrug resistance (MDR) relative protein.…”

Section: Drug Resistancementioning

confidence: 99%

“…Furthermore, Rab11a is associated with advanced TNM stage, positive nodal status and poor prognosis (Dong et al, 2017). Rab13 can induce chemotherapeutic resistance and indicates poor overall survival and progression-free survival (Chen et al, 2019). Rab21 is also highly expressed and associated with poor prognosis in pancreatic cancer (Anand et al, 2020).…”

Section: Clinical Implications Of Rab Gtpases In Cancermentioning

confidence: 99%

Rab GTPases: Central Coordinators of Membrane Trafficking in Cancer

Jin

Tang

Yang

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Tumor progression involves invasion, migration, metabolism, autophagy, exosome secretion, and drug resistance. Cargos transported by membrane vesicle trafficking underlie all of these processes. Rab GTPases, which, through coordinated and dynamic intracellular membrane trafficking alongside cytoskeletal pathways, determine the maintenance of homeostasis and a series of cellular functions. The mechanism of vesicle movement regulated by Rab GTPases plays essential roles in cancers. Therefore, targeting Rab GTPases to adjust membrane trafficking has the potential to become a novel way to adjust cancer treatment. In this review, we describe the characteristics of Rab GTPases; in particular, we discuss the role of their activation in the regulation of membrane transport and provide examples of Rab GTPases regulating membrane transport in tumor progression. Finally, we discuss the clinical implications and the potential as a cancer therapeutic target of Rab GTPases.

show abstract

RAB13 as a novel prognosis marker promotes proliferation and chemotherapeutic resistance in gastric cancer

Cited by 16 publications

References 30 publications

Exosomal miR-2276-5p in Plasma Is a Potential Diagnostic and Prognostic Biomarker in Glioma

Exosomal miR-2276-5p in Plasma Is a Potential Diagnostic and Prognostic Biomarker in Glioma

<p>A Novel lncRNA MYOSLID/miR-1286/RAB13 Axis Plays a Critical Role in Osteosarcoma Progression</p>

Rab GTPases: Central Coordinators of Membrane Trafficking in Cancer

Contact Info

Product

Resources

About