Rabbit immunoglobulin allotypy: A sixth allele at the b locus (b 95)

Benammar, A; Brézin, C; Cazenave, Pierre‐André

doi:10.1016/0161-5890(79)90031-2

Cited by 16 publications

(2 citation statements)

References 14 publications

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“…Morphological and physiological criteria easily enable one to differentiate the Fauve de Bourgogne race, which originated from a local stock in Northern France (A RNOLD , 1979) the form wild animals of Tunisia. The characterization of the Ig light chain alleles has shown that the 2 populations are genetically very different (B ENAMMAR et al , 1979 ;C AZENAVE , 1981 and. It is thus very surprising to find that both types share the same basic mtDNA, although the number of animals analysed is rather small.…”

Section: Zembra Versus Domestic Rabbitsmentioning

confidence: 99%

Rabbit mitochondrial DNA: preliminary comparison between some domestic and wild animals

Ennafaa¹,

Monnerot²,

Gaaied³

et al. 1987

Genetics Selection Evolution

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Section: Zembra Versus Domestic Rabbitsmentioning

confidence: 99%

Rabbit mitochondrial DNA: preliminary comparison between some domestic and wild animals

Ennafaa¹,

Monnerot²,

Gaaied³

et al. 1987

Genetics Selection Evolution

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“…Genomic DNA was isolated from a spleen of an homozygous b95h95 wild-derived rabbit (H626) [19].The level of Ig production was increased by hyperimmunization against Micrococcus fysodeikticus [20]. Restriction endonucleases were obtained from Amersham International (Amersham, GB) or IBI (New Haven, CT) and digestions performed according to the manufacturer's instructions.…”

Section: Southern Blot Analysismentioning

confidence: 99%

Structure of rearranged and germ‐line rabbit V_ϰ genes indicated that the CDR3 is encoded by the V_ϰ gene*

1990

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The third complementary-determining regions (CDR3) of rabbit kappa chains are unusually long and the length is more heterogeneous when compared to those of the mouse and the human kappa chains. To study how the rabbit kappa light (L) chain genes create diversity and generate CDR3, we analyzed the structure of a rearranged variable kappa gene (Vr) and the variable (Vg) and joining (Jg) regions of the putative precursor genes. Alignment of the Vr gene sequence with that of the Vg and Jg regions allowed precise determination of the recombination event. Five nucleotides between the recombination point and the J2 heptamer were deleted, indicating flexibility in the recombination producing rabbit kappa chains. The entire Vg is contained in the rearranged product demonstrating that neither a D element nor an N sequence addition are required for the CDR3 formation. Comparison of the Vr and the Vg gene sequences show base substitutions suggesting that somatic mutations may contribute to rabbit kappa L chain diversity.

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b 96, a seventh allele at the rabbit x chain b locus

Benammar

Cazenave

1981

Eur J Immunol

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A previously undetected allotypic specificity, A96, was observed in the wild rabbit population of Zembra (Tunisia). The A96 allotype is inherited as a b allotype, and its antigenic determinants are located on the kappa light chains of immunoglobulins. Although cross-reacting with b6, the A96 allotype carries its own allotypic determinants, and is therefore distinct form the known allotypes of the b series (b4, b5, b6, b9, b4var and b95). The data indicate that A96 is encoded by an allele at the b locus, tentatively designated b 96.

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Rabbit immunoglobulin allotypy: A sixth allele at the b locus (b 95)

Cited by 16 publications

References 14 publications

Rabbit mitochondrial DNA: preliminary comparison between some domestic and wild animals

Rabbit mitochondrial DNA: preliminary comparison between some domestic and wild animals

Structure of rearranged and germ‐line rabbit V_ϰ genes indicated that the CDR3 is encoded by the V_ϰ gene*

b 96, a seventh allele at the rabbit x chain b locus

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Rabbit immunoglobulin allotypy: A sixth allele at the b locus (b 95)

Cited by 16 publications

References 14 publications

Rabbit mitochondrial DNA: preliminary comparison between some domestic and wild animals

Rabbit mitochondrial DNA: preliminary comparison between some domestic and wild animals

Structure of rearranged and germ‐line rabbit Vϰ genes indicated that the CDR3 is encoded by the Vϰ gene*

b 96, a seventh allele at the rabbit x chain b locus

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Structure of rearranged and germ‐line rabbit V_ϰ genes indicated that the CDR3 is encoded by the V_ϰ gene*