1984
DOI: 10.1016/s0006-291x(84)80342-3
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Rabbit lung flavin-containing monooxygenase is immunochemically and catalytically distinct from the liver enzyme

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Cited by 105 publications
(34 citation statements)
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“…Chlorpromazine and imipramine, both excellent substrates for porcine liver FMO, were not oxygenated by the rabbit lung enzyme (Ohmiya & Mehendale, 1984). The results with the purified rabbit lung FMO confirmed this lack of turnover with chlorpromazine and imipramine (Williams et al, 1984). Utilizing a series of 10-(N,Ndimethylaminoalkyl)-2-(trifluoromethyl) phenothiazines with the alkyl side chain varying in length from 2 to 7 carbons, and a series of thioureas varying in size from thiourea to diphenylthiourea (Nagata et al, 1990), further characterized the differences between porcine liver FMO1 and rabbit lung FMO2.…”
Section: Substrate Specificity Of Enzyme-restricted Substrate Access mentioning
confidence: 57%
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“…Chlorpromazine and imipramine, both excellent substrates for porcine liver FMO, were not oxygenated by the rabbit lung enzyme (Ohmiya & Mehendale, 1984). The results with the purified rabbit lung FMO confirmed this lack of turnover with chlorpromazine and imipramine (Williams et al, 1984). Utilizing a series of 10-(N,Ndimethylaminoalkyl)-2-(trifluoromethyl) phenothiazines with the alkyl side chain varying in length from 2 to 7 carbons, and a series of thioureas varying in size from thiourea to diphenylthiourea (Nagata et al, 1990), further characterized the differences between porcine liver FMO1 and rabbit lung FMO2.…”
Section: Substrate Specificity Of Enzyme-restricted Substrate Access mentioning
confidence: 57%
“…Upon purification and characterization of the first extrahepatic FMO, Tynes et al (1985) and Williams et al (1984) documented a number of important characteristics that distinguished rabbit lung FMO (FMO2) from the porcine liver enzyme. Among these differences was a markedly distinct substrate specificity.…”
Section: Substrate Specificity Of Enzyme-restricted Substrate Access mentioning
confidence: 99%
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