Rabbit ovarian production of interleukin-6 and its potential effects on gonadotropin-induced progesterone secretion in granulosa and theca cells

Bréard, Emmanuel; Benhaïm, Annie; Féral, Colette; Leymarie, P.

doi:10.1677/joe.0.1590479

Cited by 17 publications

(8 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our earlier studies, we have noticed a reduction of estrogen and progesterone in birds stimulated to molt by high doses of zinc (Anish et al 2007). In mammals, proinflammatory cytokines have been found to inhibit ovarian steroidogenesis by inhibiting the gonadotropin-support (Bornstein et al 2004;Breard et al 1998aBreard et al , 1998bHurwitz et al 1991;Best and Hill 1995;Yasuda et al 1990;Young et al 1997). Therefore, the effect of zinc on ovarian steroids might be mediated through cytokines.…”

Section: Discussionmentioning

confidence: 99%

High doses of dietary zinc induce cytokines, chemokines, and apoptosis in reproductive tissues during regression

et al. 2008

View full text Add to dashboard Cite

In chickens, high levels of dietary zinc cause molting, and the reproductive system undergoes complete remodeling concomitant to feather replacement. In the present study, the expression profiles of cytokines and chemokines were investigated in the ovary and oviduct of control hens and of hens induced to molt by zinc feeding. The zinc-induced feed-intake suppression, the changes in corticosterone levels, the immune cell populations in the reproductive tract, and the apoptosis of reproductive tissues were analyzed. The expression of mRNAs for interleukin-6 (IL-6), interferon-gamma (IFN-gamma), the avian ortholog of mammalian IL-8 (chCXCLi2), and a chicken MIP-1beta-like chemokine (chCCLi2) in the ovary and of mRNAs for IL-1beta, IL-6, IFN-gamma, transforming growth factor-beta2, chCXCLi2, and chCCLi2 in the oviduct were upregulated significantly during zinc-induced molting. A simultaneous feed-intake reduction was observed with higher expression of cytokines and chemokines. The results of the present investigation also suggested that the upregulation of corticosterone was closely associated with the increased expression of cytokines and chemokines. An increase in apoptosis within reproductive tissue during tissue regression was also noted. We had previously observed the upregulation of these cytokines expression in an earlier study (molting by feed withdrawal). However, the pattern and the level of expression were different among these two methods. These findings indicate that cytokines might be a common mediator of tissue regression during molting induced by diverse methods, although the pattern of induction is different. Thus, a high dose of dietary zinc seems to induce reproductive regression via the upregulation of cytokines and chemokines, the suppression of feed intake, and the increase in serum corticosterone, resulting finally in the apoptosis of reproductive tissues.

show abstract

Section: Discussionmentioning

confidence: 99%

High doses of dietary zinc induce cytokines, chemokines, and apoptosis in reproductive tissues during regression

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Both granulosa and thecal cells from the rabbit produce IL-6 in vitro, modulating gonadotropin-induced progesterone secretion (40). Both granulosa and thecal cells from the rabbit produce IL-6 in vitro, modulating gonadotropin-induced progesterone secretion (40).…”

Section: Discussionmentioning

confidence: 99%

The −597 G→A and −174 G→C Polymorphisms in the Promoter of the IL-6 Gene Are Associated with Hyperandrogenism

Villuendas¹,

Millán

Sancho³

et al. 2002

The Journal of Clinical Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

To evaluate whether genetic variability at the IL-6 gene (IL-6) is associated with hyperandrogenism, we studied four common polymorphisms in the IL-6 promoter (-597G-->A, -572G--> C, -373A(n)T(n), -174G-->C) in 85 hyperandrogenic patients and 25 healthy women. We found 5 different haplotypes when considering the 3 biallelic polymorphisms at positions -597, -572, and -174 of IL-6 (relative frequencies in parentheses): GGG (0.505), AGC (0.377), GGC (0.059), GCG (0.055), and GCC (0.005). The frequencies of the GGG haplotype were 0.559 in patients and 0.320 in controls, whereas those of the AGC haplotype were 0.318 in patients and 0.580 in controls (chi(2) = 12.145; P < 0.02). The -597G-->A and -174G-->C polymorphisms were in linkage disequilibrium (chi(2) = 152.220; P < 0.00001), and were associated with patient or control status. -597G and -174G alleles were more frequent in patients in homozygosity or considering subjects homozygous and heterozygous for G alleles as a whole (P < 0.05 for all analyses). In healthy women G alleles at -597 and -174 were associated with statistically significant higher circulating levels of IL-6 and basal cortisol, 11-deoxycortisol, and 17-hydroxyprogesterone and a tendency (P < 0.10) for higher total T concentrations compared with -597A and -174C alleles. On the contrary, neither the -572G-->C nor the -373A(n)T(n) polymorphism was related to hyperandrogenism or influenced any clinical or biochemical variable. In conclusion, our present results suggest that the -597G-->A and -174G-->C polymorphisms in IL-6 are involved in the pathogenesis of hyperandrogenic disorders.

show abstract

“…TNF-α has an important role in obesity-induced insulin resistance and diabetes 7,10,13,14. A few studies suggest that TNF-α may play a role in insulin resistance in normal and diabetogenic pregnant women8,13,15 Interleukine-6 is another cytokinine produced by immune and non immune cells 16–18…”

Section: Introductionmentioning

confidence: 99%

Association of Insulin Resistance with Serum Interleukin-6 and TNF-α Levels during Normal Pregnancy

2011

View full text Add to dashboard Cite

Overview:The purpose of this study was to evaluate the role of Tumor Necrosis Factor-α (TNF-α) in insulin resistance (IR) during normal pregnancy.Approach:This cross sectional study was carried out on 86 healthy pregnant women including 26, 23 and 37 individuals in the 1st, 2nd and 3rd trimesters, respectively, and in 21 healthy non pregnant women. Serum TNF-α concentration was measured by Enzyme Linked Immunosorbent Assay (ELISA) method.Results:There were significant differences between serum TNF-α and IL-6 levels in pregnant women as compared with maternal healthy controls. There was significant correlation between gestational age and Body Mass Index (BMI) (r = 0.28, P = 0.01). There was no significant correlation between gestational age and insulin resistance (IR). We also did not find correlations between IR and TNF-α and IR and IL-6 in pregnant women.Conclusion:In conclusion, our findings suggest that TNF-α and IL-6 are not greatly contributed to pregnancy induced insulin resistance in normal pregnancy.

show abstract

Rabbit ovarian production of interleukin-6 and its potential effects on gonadotropin-induced progesterone secretion in granulosa and theca cells

Cited by 17 publications

References 22 publications

High doses of dietary zinc induce cytokines, chemokines, and apoptosis in reproductive tissues during regression

High doses of dietary zinc induce cytokines, chemokines, and apoptosis in reproductive tissues during regression

The −597 G→A and −174 G→C Polymorphisms in the Promoter of the IL-6 Gene Are Associated with Hyperandrogenism

Association of Insulin Resistance with Serum Interleukin-6 and TNF-α Levels during Normal Pregnancy

Contact Info

Product

Resources

About