Rabies Vaccination in a Small Zoo: Antibody Titers Studies

Abstract

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Results of vaccination of Asian elephants (Elephas maximus) with monovalent inactivated rabies vaccine

“…[1][2][3][4][5][6] Despite these concerns, the use of killed-rabies virus vaccines has been recommended for many mammals in zoologic collections. [1][2][3][4][5][6] Despite these concerns, the use of killed-rabies virus vaccines has been recommended for many mammals in zoologic collections.…”

“…[1][2][3][4][5][6] Despite these concerns, the use of killed-rabies virus vaccines has been recommended for many mammals in zoologic collections. 1,5 Most captive mammals in zoos are considered to be at low risk for infection with rabies virus because they are typically managed with a strict quarantine program, are generally isolated from indigenous wildlife, and are observed daily for abnormal behavior. 1,5 Most captive mammals in zoos are considered to be at low risk for infection with rabies virus because they are typically managed with a strict quarantine program, are generally isolated from indigenous wildlife, and are observed daily for abnormal behavior.…”

Resposta imune humoral de macacos-pregos (Cebus apella) após vacinação com vacina anti-rábica inativada produzida em cérebros de camundongos lactentes: comparação de dois esquemas de imunização

“…In areas where rabies occurs endemically, the immunization of animals belonging to zoos must be considered; above all, when the colonies present a high risk of exposure to the rabies virus 12,15,16 , avoiding, this way, the dissemination of the disease among exposed animals as well as among different species of susceptible mammals, there including man.…”

“…After vaccination, all those monkeys had been exposed produced neutralizing antibodies presenting titers higher than 0.5 IU/mL Taking into account the SMBV prescribed for dogs and cats, have been administered either subcutaneously or intramuscularly in different species of Neotropical primates as well as in monkeys of the Old World with the purpose of verifying the immunization schedules adopted to, which resulted in a humoral immune response. After a single dose of the SMBV vaccine, the production of neutralizing antibodies to rabies was observed in Callithrix spp in 16.6% (1/6) 20 and 100% (7/7) 21 of the animals; in 100.0% (3/3) of the Saimiri spp 15 ; in 80.0% (8/10) in Macaca mulatta 16 ; and, in 80.0% (4/5) in Macaca mulatta 22 ; after two doses of the vaccine, it was observed in 33.3% (2/6) of the Callithrix spp specimens 20 and, in 100.0% (10/10) in Macaca mulatta 16 ; after three doses of the vaccine, it was observed in 100.0% (8/8) of the Cebus apella specimens 8 ; and, after four doses of the vaccine, it was observed in 100.0% (6/6) of the Callithrix spp specimens 20 . As conclusive results regarding the value of rabies antibody titers for non-human species were not found in the literature, it is worth emphasizing that, in the present paper, we have used the values of the humans…”