2015
DOI: 10.1093/bja/aev183
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Racemic ketamine 4.5-day infusion treatment of long-standing complex regional pain syndrome—a prospective service evaluation in five patients

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Cited by 8 publications
(7 citation statements)
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“…One observational study by Goebel et al evaluated the short-and long-term analgesic effects of 4.5-day, low-dose (0.9mg/kg/hr) racemic ketamine (RK) infusions in five patients with refractory CRPS. 37 The study authors found that intravenous infusion of low, subanesthetic doses of RK over a 4.5-day period can substantially reduce pain in patients with CRPS with 60% of patients reporting substantial pain relief during the treatment period. 37 The median pain intensity at the beginning of the treatment period was NRS 8.5, and was reduced to NRS 5 on the last treatment day.…”
Section: Discussionmentioning
confidence: 93%
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“…One observational study by Goebel et al evaluated the short-and long-term analgesic effects of 4.5-day, low-dose (0.9mg/kg/hr) racemic ketamine (RK) infusions in five patients with refractory CRPS. 37 The study authors found that intravenous infusion of low, subanesthetic doses of RK over a 4.5-day period can substantially reduce pain in patients with CRPS with 60% of patients reporting substantial pain relief during the treatment period. 37 The median pain intensity at the beginning of the treatment period was NRS 8.5, and was reduced to NRS 5 on the last treatment day.…”
Section: Discussionmentioning
confidence: 93%
“…37 The study authors found that intravenous infusion of low, subanesthetic doses of RK over a 4.5-day period can substantially reduce pain in patients with CRPS with 60% of patients reporting substantial pain relief during the treatment period. 37 The median pain intensity at the beginning of the treatment period was NRS 8.5, and was reduced to NRS 5 on the last treatment day. 37 The authors concluded that low-dose RK infusion over the duration of 4.5 days provided beneficial analgesia for short durations, but further prospective trials are needed to understand long-term pain control with multiple repeat ketamine infusions.…”
Section: Discussionmentioning
confidence: 93%
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“…Low‐dose ketamine infusion treatment is, to our knowledge, the only pharmacological option that has been shown to achieve temporary pain relief in this group. However, unlike with neuromodulation, data about efficacy and risks of repeated administrations are not available; in a U.K. setting the cost effectiveness of this treatment, which requires regular repeat infusions, has not been established, and we have abandoned its use at our center . The primary surgical trial of spinal cord stimulation (ie, asleep surgical insertion) is a technique in keeping with international guidelines, but uncommonly used nowadays .…”
Section: Discussionmentioning
confidence: 99%