Racemic trans-1,2-diaminocyclohexane as a template in the synthesis of ligands for transition metal and actinide in vivo detoxification

Abstract

Trans 1,2-diamino cyclohexane was used as a template for building EDTA-like derivatives that can act as strong complexation agents in vivo. Cyclohexane diamino tetraphosphonate (CDTP) and diamino diphosphonate (CDDP) ligands were synthetized with the aim to decorporate living organisms for heavy atoms or actinides following accidental ingestion. The stability of the complexes with calcium, copper, and cobalt were obtained in vitro and compared to those of EDTA or DTPA. The X-ray structure of CDDP confirms its strong ability to form highly stable complexes.