Racemization of L-lysine for pharmaceutical synthesis and its chiral separation by GC-MS spectroscopy

Cheong, Jae Yeon; Choi, Su Hang; Woo, Nam Tae; Shin, Jae Young; Kim, Su Woong; Jung, Won Tae

doi:10.1007/bf02979136

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Chirai Separation O F Enantiomers1

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1996

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“…Then the enantiomers to be separated interact with the chiral stationary phase (L-valine /ert-butyl-amide linked to polysiloxane) via hydrogen bonds to form diastereomeric association complexes with differences in their solvation enthalpy of a hundred calories [ 10]. Mass spectroscopy using quadrupole single-mass scan under conditions reported elsewhere [11] was carried out. Figure 4 shows the chromatography of A-E-amino acids in water-insoluble protein from control lens.…”

Section: Chirai Separation O F Enantiomersmentioning

confidence: 99%

Racemization of Lens Crystalline Constituents in UV-lnduced Cataract Evaluated by Chiral GC/MS Spectroscopy

1996

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The racemization of amino acids is hypothesized to caust cataract by disrupting the crystalline’s tertiary structure which, in turn, alters the optical characteristics of the lens. Tc better understand the role of these modifications in cataracto·genesis, the changes in stereoisomer ratio of amino acids fron lens crystalline by UV-B-induced cataract in animal models were studied using chiral separation gas chromatography-single quadrupole mass spectroscopy. The anticataract actior of a compound, {[l-(phenylmethyl)-lH-indazol-3-yl]oxy}acetk acid lysinate, was also evaluated by this method.

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Section: Chirai Separation O F Enantiomersmentioning

confidence: 99%