Racial admixture in north‐eastern Brazil

Krieger, Henrique; Morton, N. E.; Mi, M. P.; Azevêdo, Eliane S.; Freire‐Maia, Ademar; Yasuda, Norikazu

doi:10.1111/j.1469-1809.1965.tb00507.x

Cited by 215 publications

(169 citation statements)

References 14 publications

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“…Race was described as white, mulatto and black by subjective evaluation based on established criteria by KRIEGER et al (8) and modified by AZEVÊDO (1) . All patients with Crohn's disease evaluated at the study period were included in the study.…”

Section: Methodsmentioning

confidence: 99%

Application of the Vienna classification for Crohn’s disease to a single center from Brazil

Santana

Souza

Azevedo

et al. 2008

Arq. Gastroenterol.

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BACKGROUND: Crohn’s disease is a chronic inflammatory disorder with diversity on its clinical presentation that may be observed from the varying age of onset of symptoms to the site of occurrence of the illness. There is a need for a replicable and uniform description of the disease allowing a comparison between distinct study populations. The 1998 Vienna classification characterizes patients according to three clinical aspects: age at diagnosis, location and disease behavior. AIM: To describe Crohn’s disease in patients from a reference center of Salvador, BA, Brazil according to the Vienna classification. METHODS: Between January and October of 2005, patients (n = 47) having at least one endoscopic and radiological examination of the intestine participated in this study. RESULTS: Most of the participants had the diagnosis of the disease when they were younger than 40 years old (70.2%) while an ileocolic location (38.3%) and the penetrating form (46.8%) were the most prevalent clinical presentation. The restricted location of the ileum (L1) was more frequent in nonstricturing, nonpenetrating disease (B1) while the ileocolic disease (L3) was more associated with the penetrating behavior (B3). CONCLUSION: In this study, differently from the first description of the Vienna classification, the large number of patients presenting a complicated stage of the disease can be attributed to the fact that it was carried out at a reference center, where many patients present with the disease at an advanced stage.

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Section: Methodsmentioning

confidence: 99%

Application of the Vienna classification for Crohn’s disease to a single center from Brazil

Santana

Souza

Azevedo

et al. 2008

Arq. Gastroenterol.

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“…Mdh and Hk phenotypes were used to estimate allelic frequencies, verify genetic equilibrium of the populations for these loci and determine the racial admixture, according to the Krieger et al (1965) method. F-statistics values, genetic distances among populations according to Nei (1978) and Cavalli-Sforza and Edwards (1967), and the respective dendrograms were estimated with the Biosys-1 program (Swofford and Selander, 1981).…”

Section: Methodsmentioning

confidence: 99%

Genetic structure of honeybee populations from southern Brazil and Uruguay

et al. 2003

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Apis mellifera scutellata was introduced to Brazil in 1956 and Africanized honeybee populations have now spread from Argentina to the southwestern United States. Temperate climatic restrictions seem to be a natural limit to Africanized honeybee expansion around parallels 35°to 40°SL. We used allozyme loci (Mdh-1 and Hk-1) and mtDNA haplotypes to characterize honeybee populations in southern Brazil and Uruguay and define a possible transition area between Africanized and European bees. Samples of 194 bee colonies were collected from ten localities between 30°-35°SL and 52°-59°WL. The mtDNA restriction patterns of these colonies were obtained through digestion of the mitochondrial genome by Eco RI, or by digestion by Bgl II and Xba I of the cytochrome B locus and the COI-COII intergenic region, respectively. The distribution limit of African bee colonies, i.e., those populations with only the African mtDNA haplotype and with a high proportion of African genes as shown by allozyme analysis, is located in northern Uruguay, with a hybridization zone located farther south in Uruguay. A gradual cline from north to south was observed, confirmed by mtDNA, racial admixture, and genetic distance analyses. No evidence of either gametic disequilibrium between nuclear markers or cytonuclear disequilibrium among the nuclear and mtDNA genotypes was detected, suggesting that the hybridization process has been completed.

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“…22 Essa classificação foi escolhida devido à baixa acurácia na detecção dos tipos mulato claro, mulato escuro e negro e à pequena quantidade de indivíduos da etnia amarela existente nas amostras estudadas. Assim, mulatos claros, mulatos escuros, pretos e amarelos foram classificados como não-caucasóides.…”

Section: Grupo éTnicounclassified

Estudo das mutações C282Y, H63D e S65C do gene HFE em doentes brasileiros com sobrecarga de ferro

Cançado¹,

Guglielmi²,

Vergueiro³

et al. 2007

Rev. Bras. Hematol. Hemoter.

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IntroduçãoOs avanços técnicos e científicos obtidos nas últimas décadas, particularmente com o desenvolvimento da biologia molecular, permitiram maior conhecimento do metabolismo normal do ferro, dos principais fatores relacionados à sua regulação bem como dos distúrbios que podem resultar em deficiência ou sobrecarga de ferro. 1-4Até a década de 90, hemocromatose hereditária (HH) era considerada doença rara, acometendo predominantemente indivíduos do sexo masculino, cujo diagnóstico era realizado, na maioria das vezes, em doentes internados ou por autópsia. 5A partir de 1996, a identificação do gene HFE e de suas mutações possibilitaram o diagnóstico precoce da HH, que passou a ser considerada uma das doenças genéticas mais freqüentes do ser humano, sobretudo em indivíduos caucasianos do nordeste Europeu. 2,[4][5][6][7] A constatação de que a pronta instituição do tratamento é capaz de prevenir o aparecimento de complicações orgâ-nicas graves e, até mesmo, reverter possíveis lesões orgâni-cas funcionais já estabelecidas, proporcionando melhor qualidade de vida e maior sobrevida ao doente, colocou em evidência a importância de estudos populacionais com o objetivo de identificar os doentes portadores de HH o mais precocemente possível. [8][9][10][11]

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Racial admixture in north‐eastern Brazil

Cited by 215 publications

References 14 publications

Application of the Vienna classification for Crohn’s disease to a single center from Brazil

Application of the Vienna classification for Crohn’s disease to a single center from Brazil

Genetic structure of honeybee populations from southern Brazil and Uruguay

Estudo das mutações C282Y, H63D e S65C do gene HFE em doentes brasileiros com sobrecarga de ferro

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