Racial differences in coagulation studies in stroke

Gaines, Kenneth; Chesney, Carolyn M.; Zwaag, Roger Vander; Cape, Charles A.

doi:10.1080/01616412.1992.11740024

Cited by 13 publications

(9 citation statements)

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“…Fibrinogen was positively associated with history of TTA or stroke in Blacks but not in Whites in the Atherosclerosis Risk in Communities Study (83). Racial differences in the prevalence of abnormal levels of several coagulation factors and indicators of platelet function in normal persons and stroke patients indicate the need for further studies (34,84).…”

Section: Conditions Affecting Blood Viscosity and Coagulationmentioning

confidence: 93%

“…The relation between blood lipid levels and stroke risk in Blacks has been insufficiently studied (4,(83)(84)(85)(86)(87). Serum total cholesterol was not related to stroke incidence in Blacks or Whites in the Evans County cohort (57), but a significant relation was found with hospitalization for cerebral thrombosis in the health maintenance organization cohort (27) and with nonhemorrhagic stroke mortality in the Multiple Risk Factor Intervention Trial cohort (22).…”

Section: Blood Lipidsmentioning

confidence: 95%

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Risk Factors for Stroke in Blacks: A Critical Review

Gillum

1999

American Journal of Epidemiology

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Stroke is the third leading cause of death in US Blacks and is an important cause of mortality and morbidity worldwide. Mortality rates are higher in Blacks than in Whites in the United States at ages below 70 years. In Blacks, advanced age, elevated blood pressure, diabetes mellitus, and smoking are the only risk factors for stroke whose status has been firmly established by published data. More data are needed to assess other likely risk factors of importance for risk stratification and intervention and to determine the fraction of racial differences in stroke that may be explained by risk factor differences. Higher prevalences of hypertension, diabetes, obesity (in women), elevated lipoprotein(a) level, smoking (in men), and low socioeconomic status may contribute to the higher stroke incidence and mortality in US Blacks as compared with Whites. However, further environmental influences must be studied and candidate genes identified before assuming that racial differences can be attributed to inborn susceptibility linked to inheritance of specific genes.

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Section: Conditions Affecting Blood Viscosity and Coagulationmentioning

confidence: 93%

Section: Blood Lipidsmentioning

confidence: 95%

Risk Factors for Stroke in Blacks: A Critical Review

Gillum

1999

American Journal of Epidemiology

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“…This is particularly true of hy pertension, which is common in African Americans [36,37], Jamaicans [38] and AfroCaribbean immigrants to the UK [39]. These populations are also at an increased risk for stroke [ 11,40] and show an increased preva lence of cardiovascular risk factors such as diabetes [41], abnormalities of coagulation [42] and abnormalities of lipoprotein metabo lism [43], Of particular interest in the present context is a meta-analysis showing that systolic blood pressure levels are higher in African Ameri cans than in people from sub-Saharan Africa [44], Urbanization is associated with in creased systolic blood pressure in sub-Saha ran Africans [45]. The reverse appears to be true of African Americans [44], which is con sistent with the phenomenon of rural dwelling as a risk factor for PD in the USA.…”

Section: Risk Factors For Pdmentioning

confidence: 99%

Parkinson's Disease in Populations of African Origin A Review

Richards

Kr²

1996

Neuroepidemiology

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Several studies have reported a lower prevalence of Parkinson''s disease (PD) in populations of African origin than in populations of European origin, raising the possibility that the former are protected against PD. However, the confounding effects of low case ascertainment and high selective mortality on PD prevalence estimates in populations of African origin cannot be ruled out at this time. One hypothesis consistent with available data is that populations of African origin are vulnerable to vascular parkinsonism, which is associated with high mortality.

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“…12 Several variables may influence D-dimer levels. [13][14][15][16][17][18][19][20][21][22] Cotè and colleagues demonstrated that in patients with a recent ( 7 days) TIA and asymptomatic individuals with a cervical bruit, D-dimer level was significantly higher compared with control group, but no significant differences were found between the two groups. 13 Other variables are age, 14 race, 15 time of onset, 16 and stroke subtypes.…”

mentioning

confidence: 99%

D-Dimer Testing in Ischemic Stroke and Cerebral Sinus and Venous Thrombosis

Squizzato¹,

Ageno²

2005

Seminars in Vascular Medicine

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D-dimer measurement is commonly included in the diagnostic workup of patients with suspected acute symptomatic deep venous thrombosis and pulmonary embolism. As a haemostatic marker, it could be theoretically useful in other thromboembolic disorders, such as acute cerebrovascular events. In this review we summarize published literature on D-dimer testing in acute ischemic stroke and cerebral sinus and venous thrombosis (CSVT), discussing possible clinical diagnostic and therapeutical applications. In ischemic stroke, mounting evidence suggests a possible role of D-dimer in the acute diagnosis of ischemic stroke subtypes, especially in identifying tromboembolic and lacunar stroke. Its prognostic role still remains unclear, due to conflicting data. D-dimer could be also an useful screening test for excluding CSVT in patients presenting with acute headache, making the presence of cerebral thrombosis unlikely with low plasma levels. In this clinical setting sensitivity and negative predictive value are comparable to that reported in the diagnosis of acute thromboembolic disease. However, more studies are needed to confirm these recent findings as well as management studies to correctly introduce D-dimer measurement in clinical daily practice of ischemic stroke and CSVT.

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Racial differences in coagulation studies in stroke

Cited by 13 publications

References 0 publications

Risk Factors for Stroke in Blacks: A Critical Review

Risk Factors for Stroke in Blacks: A Critical Review

Parkinson's Disease in Populations of African Origin A Review

D-Dimer Testing in Ischemic Stroke and Cerebral Sinus and Venous Thrombosis

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