Background: Social distancing measures (SDMs) protect the health of the public from coronavirus 2019 (COVID-19) infection. However, the impact of SDMs has been inconsistent and unclear. This study aims to review the factors impacting SDMs (e.g. isolation, quarantine) for reducing the transmission of COVID-19.Methods: A systematic review was conducted. We searched MEDLINE, EMBASE, Allied & Complementary Medicine, COVID-19 Research and WHO database on COVID-19 for primary studies assessing the enablers and barriers associated with SDMs, and reported in accordance with PRISMA statement. We used JBI Critical Appraisal Checklist for the cross-sectional survey and Qualitative Research to assess the methodological qualities and synthesised performing thematic analysis. Two reviewers independently screened the papers and extracted data.Results: A total of 1235 citations were identified, of which 16 were found to be relevant. The studies reported in two broad categories, under seven separate themes: positive impact of SDMs, effective public health interventions, positive change in people’s behaviour, worries and concerns about COVID-19, roles of mass media, physical and psychological impacts, and ethnicity/age associated with COVID-19.Conclusion: The identified evidence signals that SDMs are generally effective for preventing or reducing transmission. There is a scope and need to find the best methods and approaches at the primary healthcare level in terms of developing objective measures and interventions to establish the link between different factors and SDMs and reducing transmission of COVID-19 trend effectively, efficiently and equitably.