Racial disparities in risk factors for thrombosis

Itakura, Haruka

doi:10.1097/01.moh.0000167746.26145.53

Cited by 25 publications

(19 citation statements)

References 72 publications

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“…The study population comprises only a Caucasian population so racial disparities in the risk of thrombosis can be discounted. 42 Besides, we analyzed only symptomatic VTE events because there was no routine screening for VTE.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the ThroLy score for the prediction of venous thromboembolism in newly diagnosed patients treated for lymphoid malignancies in clinical practice

Rupa‐Matysek

Brzeźniakiewicz‐Janus

Gil

et al. 2018

Cancer Medicine

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The utility in clinical practice of a recently developed and validated predictive model for venous thromboembolism (VTE) events in lymphoma patients, known as the thrombosis lymphoma (ThroLy) score, is unknown. We evaluated the association of ThroLy with VTE in patients treated for diffuse large B‐cell lymphoma (DLBCL) or Hodgkin lymphoma (HL) undergoing ambulatory first‐line chemotherapy. Retrospective analyses were performed on 428 patients (median age 50), 241 were newly diagnosed DLBCL, and 187 had HL. During initial chemotherapy, 64 (15%) patients developed VTE. According to the ThroLy, 322 (75.2%) patients were considered low risk, 88 (20.6%) patients had intermediate risk and 18 (4.2%) patients high risk for VTE development. Patients with DLBCL were more often in the high‐risk ThroLy group and had more VTE events than HL. VTE occurred in; 38.9% (n = 7) high‐risk patients, 29.5% (n = 26) intermediate risk, and 9.6% (n = 31) low risk according to the ThroLy score. However, in multivariate analysis, high ThroLy (OR 5.13; 95% CI: 1.83‐14.36, P = .002), intermediate ThroLy (OR 3.96; 95% CI: 2.19‐7.17, P < .001), and aggressive lymphoma‐DLBCL (OR 1.91; 95% CI: 1.05‐3.47, P = .034) were all significantly associated with development of VTE, 48% of the VTE events occurred in the low‐risk ThroLy score group (the ROC AUC (95% CI) 0.40‐0.70 and C statistic‐0.55). In our study, the ThroLy score was not a suitably accurate model for predicting VTE events in patients at higher risk of VTE. Further research should be conducted to identify new biomarkers that will predict these events and to establish a new VTE risk assessment model.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the ThroLy score for the prediction of venous thromboembolism in newly diagnosed patients treated for lymphoid malignancies in clinical practice

Rupa‐Matysek

Brzeźniakiewicz‐Janus

Gil

et al. 2018

Cancer Medicine

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“…Therefore, the use of the term ethnicity, which represents social groups with a shared history, sense of identity, geography and cultural roots which may occur despite racial difference, seems more appropriate in this context. The incidence of VTE varies widely among diverse ethnic cohorts, but as yet the determinants of different risk remain to be thoroughly evaluated [6,7]. Explanations can include both genetic and environmental influences including differences in lifestyle traits, the prevalence of obesity, psychosocial stress, and accessibility to medical care associated with socioeconomic status [8].…”

Section: Influence Of Ethnicity On Genetic Predisposition To Vtementioning

confidence: 98%

The role of ethnicity, age and gender in venous thromboembolism

Montagnana

Favaloro

Franchini

et al. 2009

J Thromb Thrombolysis

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Venous thromboembolism, including both deep venous thrombosis and pulmonary embolism, is the leading cause of preventable in-hospital mortality. In the inexorable progress towards individualization of risk and personalized medicine, several congenital and acquired risk factors have been identified. However, the influence of some demographical variables, especially ethnicity, age and gender, has largely been under appreciated. Although the incidence of venous thromboembolism varies widely among diverse racial/ethnic cohorts, it appears globally highest in Blacks, is intermediate in Caucasians and is lowest in Asians. The incidence and prevalence of venous thromboembolism is also strongly age-related, increasing nearly 90 fold from <15 to >80 years old. Definitive data on the relative frequency of venous thromboembolism across genders is lacking. Some studies report that gender is not an independent risk factor of venous thromboembolism, while others conclude that female gender might be a protective variable. The purpose of this review is to assess the relationship between such demographic variables and venous thromboembolism.

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“…In contrast, the association of elevated FIX and FXI levels as independent risk factors for VTE was inconsistent with abolition of the risk on multivariate analysis after adjusting for FVIII levels and other confounding factors [15,16]. A racial disparity in the context of VTE risk factors is well known [17]. It is known that the hereditary thrombophilic risk factors have a different prevalence in different ethnic populations.…”

Section: Introductionmentioning

confidence: 93%

Coagulation factor VIII, IX and XI levels in north Indian patients with venous thromboembolism

Chougule¹,

Rajpal²,

Ahluwalia³

et al. 2016

Blood Coagulation &Amp; Fibrinolysis

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Studies have shown elevated levels of certain coagulation factors as risk factors for venous thromboembolism (VTE). In this study, we investigated the levels of coagulation factor VIII (FVIII), FIX and FXI in north Indian patients with VTE. A total of 123 patients with VTE were screened prospectively for FVIII, FIX and FXI levels and the conventional risk factors - deficiencies of protein C, S and antithrombin, positivity for antiphospholipid antibodies and the factor V Leiden mutation. Age-matched and sex-matched controls were included. VTE was secondary to known circumstantial and thrombophilic risk factors in 66 (53.7%) patients. In 46.3% (idiopathic VTE) patients, no cause was identified. The mean FVIII levels in idiopathic (187 IU/dl) and secondary VTE patients (185.4 IU/dl) were significantly higher compared with controls (129.6 IU/dl; P < 0.001). However, there was no statistically significant difference in the levels of FIX and FXI between patients and controls (P = 0.214 and 0.198, respectively). Patients with elevated FVIII levels had increased risk of VTE compared with controls (odds ratio: 9.4, 95% confidence interval: 4.7-18.79). On logistic regression analysis after adjusting for surgery and presence of antiphospholipid antibodies, this risk remained unchanged (odds ratio: 9.54, 95% confidence interval: 4.68-19.44). A dose-response relationship was observed with progressive increase in FVIII levels. Elevated FVIII levels constitute an independent risk factor for VTE in the north Indian population. Elevated levels of FIX and FXI were not associated with increased risk of VTE.

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Racial disparities in risk factors for thrombosis

Cited by 25 publications

References 72 publications

Evaluation of the ThroLy score for the prediction of venous thromboembolism in newly diagnosed patients treated for lymphoid malignancies in clinical practice

Evaluation of the ThroLy score for the prediction of venous thromboembolism in newly diagnosed patients treated for lymphoid malignancies in clinical practice

The role of ethnicity, age and gender in venous thromboembolism

Coagulation factor VIII, IX and XI levels in north Indian patients with venous thromboembolism

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