Radar Signatures for Aircraft Identification.

Strattan, R. D.

doi:10.21236/ada052447

Cited by 4 publications

(4 citation statements)

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“…98 The low aqueous solubility of -CD is due in large part to intramolecular hydrogen bonding between the secondary hydroxyl groups, which are unfavorable to the interaction of -CD with surrounding water molecules. 10,11,81,89,[101][102][103][104][105][106][107][108] The results in Table 4 clearly indicate that HP--CD has very low toxicity when administered via the parenteral route even at high doses, and the effects of HP--CD on the kidney are reversible and similar to those observed for osmotic agents that are currently being used for parenteral formulations. In this respect, DM--and TM--CDs are 26 times and 13 times more soluble, respectively, than -CD in water at 25°C on a molar basis.…”

Section: Safety Profilesmentioning

confidence: 99%

Pharmaceutical Applications of Cyclodextrins. III. Toxicological Issues and Safety Evaluation

Irie

Uekama

1997

Journal of Pharmaceutical Sciences

843

520

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The objective of this review is to summarize recent findings on the safety profiles of three natural cyclodextrins (alpha-, beta- and gamma-CDs) and several chemically modified CDs. To demonstrate the potential of CDs in pharmaceutical formulations, their stability against non-enzymatic and enzymatic degradations in various body fluids and tissue homogenates and their pharmacokinetics via parenteral, oral, transmucosal, and dermal routes of administration are outlined. Furthermore, the bioadaptabilities of CDs, including in vitro cellular interactions and in vivo safety profiles, via a variety of administration routes are addressed. Finally, the therapeutic potentials of CDs are discussed on the basis of their ability to interact with various endogenous and exogenous lipophiles or, especially for sulfated CDs, their effects on cellular processes mediated by heparin binding growth factors.

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Section: Safety Profilesmentioning

confidence: 99%

Pharmaceutical Applications of Cyclodextrins. III. Toxicological Issues and Safety Evaluation

Irie

Uekama

1997

Journal of Pharmaceutical Sciences

843

520

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“…This separation was obtained when b-cyclodextrin was added to the running buffer. Cyclodextrins (CD) are cylindrical polysaccharides that posses a hydrophobic cavity into which molecules of particular size, shape, and polarity can fit [17]. The addition of CD to a CE running buffer creates an opportunity for solutes to partition between the bulk buffer solution and the CD molecules thus aiding in separation [15].…”

Section: Resultsmentioning

confidence: 99%

Analysis of intermediates from polycyclic aromatic hydrocarbon biodegradation

Copper¹

2003

J of Separation Science

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A major difficulty in assessing bioremediation in hydrocarbon impacted field sites is the determination of the extent and products of contaminant biodegradation. Previously, various analytical techniques, including mass spectrometry and chromatography, have been used to characterize components in mixtures resulting from biodegradation. In this work, the applicability of capillary electrophoresis (CE) to this area of research is demonstrated. CE methods were optimized for analysis of compounds that are known metabolites of polycyclic aromatic hydrocarbon (PAH) biodegradation.

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“…It has now wider applications for making various inclusion complexes. Some naturally and chemically modified CDs are getting practical importance because of their high solubility in aqueous solutions [30]. The CD hydrolyzing enzyme may be applicable to industrial production of linear G6, G7 and G8 from CDs.…”

Section: Discussionmentioning

confidence: 99%