Radial glia in the human fetal cerebrum: A combined golgi, immunofluorescent and electron microscopic study

Choi, BongKyoo; Lapham, Lowell W.

doi:10.1016/0006-8993(78)90721-7

Cited by 263 publications

(121 citation statements)

References 21 publications

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“…We confirmed that the majority of isolated LeX ϩ cells could be colabeled with known RG markers (Choi and Lapham, 1978;Dahl et al, 1981;Feng et al, 1994;Kamei et al, 1998) and had a typical elongated morphology, qualifying them as a subset of the RG cell population (Mai et al, 2003). Although almost all LeX ϩ cells express RG markers, not all RGs expressed LeX, which is in accord with described heterogeneity of RG antigen profile in both rodent (Hartfuss et al, 2001;Malatesta et al, 2003) and human fetal brain (Howard et al, 2006).…”

Section: Multipotent Progenitor Cellssupporting

confidence: 85%

Human Cortical Neurons Originate from Radial Glia and Neuron-Restricted Progenitors

Mo¹,

Moore²,

Filipovic³

et al. 2007

J. Neurosci.

103

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Understanding the molecular and physiological determinants of cortical neuronal progenitor cells is essential for understanding the development of the human brain in health and in disease. We used surface marker fucose N-acetyl lactosamine (LeX) (also known as CD15) to isolate progenitor cells from the cortical ventricular/subventricular zone of human fetal brain at the second trimester of gestation and to study their progeny in vitro.

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Section: Multipotent Progenitor Cellssupporting

confidence: 85%

Human Cortical Neurons Originate from Radial Glia and Neuron-Restricted Progenitors

Mo¹,

Moore²,

Filipovic³

et al. 2007

J. Neurosci.

103

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“…The presence of Cx 43 in radial glial fibers during the period of neuronal migration suggests that neurons establish contact and communication with the scaffolding they use as they migrate to the cortical plate. As neuronal migration tapers off, radial glial cells are transformed into fibrillary and protoplasmic astrocytes (Choi and Lapham, 1978;Schmechel and Rakic, 1979) and are added to the existing population of astrocytes known to form networks connected by gap junctions in the cortex (Bennett and Goodenough, 1978;Massa and Mugnaini, 1982;Yamamoto et al, 1990). The localization of Cx 43 in radial glia indicates that these cells possess the necessary Cxs to form gap junctions.…”

Section: Gap Junctions and Expression Of Cxs During Corticogenesismentioning

confidence: 99%

Differential Expression of Connexins during Neocortical Development and Neuronal Circuit Formation

et al. 1997

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Gap junctions are membrane channels that mediate the direct passage of ions and molecules between adjacent cells. Recent tracer coupling and optical recording studies have revealed the presence of gap junction-mediated communication between neurons during neocortical development. We have visualized gap junctions in the developing rat cerebral cortex with electron microscopy and studied the pattern of expression and cellular localization of connexins 26, 32, and 43 that take part in their formation. We found that these connexins (Cxs) are expressed differentially during development, and their patterns of expression are correlated with important developmental events such as cell proliferation, migration, and formation of cortical neuronal circuits. Specifically, we observed that the developmental profile of Cx 26 during the first 3 weeks of postnatal life matched closely the development of neuronal coupling, suggesting that coupled neurons use this gap junction protein during circuit formation in the cortex. The subsequent diminution of Cx 26 was mirrored by an increase in Cx 32 immunoreactivity, which became pronounced at the late stages of cortical maturation. In contrast, Cx 43 was localized in the cortex throughout the period of development. Its localization in radial glial fibers closely associated with migrating neurons suggests that this Cx may be involved in neuronal migration.

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“…1, Jan. 19811971, 1972Schmechel and Rakic, 1979). More recently, immunocytochemical staining for the specific glial librillary acid protein (GFA) (Bignami et al, 1972;Eng, 1980;Eng and Bigbee, 1978;Eng et al, 1971;Ludwin et al, 1976) provided more direct evidence of the presence of radial glial cells during early periods of neurogenesis in the human cerebrum (Antanitus et al, 1976;Choi and Lapham, 1978) and in all major subdivisions of the fetal monkey central nervous system (Levitt and Rakic, 1980). This method showed that the number of radial glial cells increases during periods of peak neuronal proliferation and subsides only after neuronal migration ceases (Levitt and Rakic, 1980).…”

mentioning

confidence: 99%

Coexistence of neuronal and glial precursor cells in the cerebral ventricular zone of the fetal monkey: an ultrastructural immunoperoxidase analysis

Levitt¹,

Cooper²,

Rakić³

1981

J. Neurosci.

362

134

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Radial glia in the human fetal cerebrum: A combined golgi, immunofluorescent and electron microscopic study

Cited by 263 publications

References 21 publications

Human Cortical Neurons Originate from Radial Glia and Neuron-Restricted Progenitors

Human Cortical Neurons Originate from Radial Glia and Neuron-Restricted Progenitors

Differential Expression of Connexins during Neocortical Development and Neuronal Circuit Formation

Coexistence of neuronal and glial precursor cells in the cerebral ventricular zone of the fetal monkey: an ultrastructural immunoperoxidase analysis

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