Radiation cross-linked carboxymethyl sago pulp hydrogels loaded with ciprofloxacin: Influence of irradiation on gel fraction, entrapped drug and in vitro release

Lam, Yi; Muniyandy, Saravanan; Hashim, Kamaruddin; Ahmad, Muhammad Ashfaq; Pushpamalar, Janarthanan

doi:10.1016/j.radphyschem.2014.07.018

Cited by 24 publications

(11 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A pectina é um heteropolissacarídeo encontrado principalmente na lamela média e na parede celular primária das plantas, sendo responsável pela manutenção de estruturas e pela sustentação da planta 44,45 Quimicamente, as pectinas são macromoléculas compostas por homogalacturonana (HG) e ramnogalacturonanas (RG), que são divididas em dois tipos: ramnogalacturonanas І (RG І) e ramnogalacturonanas ІІ (RG ІІ). Ainda existe um quarto domínio denominado xilogalacturonana (XG) 45,48 .…”

Section: Pectinaunclassified

“…De acordo com o DE, as pectinas são divididas em duas classes: pectinas de alto grau de metoxilação, quando DE > 50%, e pectinas de baixo grau de metoxilação, com um DE < 50% 44,58 .…”

Section: Pectinaunclassified

“…Dentro da área farmacêutica vem sendo explorada para o desenvolvimento de novos sistemas de liberação de fármacos, devido às propriedades promissoras desse material como baixa toxicidade, biocompatibilidade, degradabilidade e baixo custo 60,61 . Outra vertente muito explorada é a utilização da pectina como excipiente na obtenção de sistemas de liberação cólon-específica de fármacos, uma vez que em meio ácido permanece como agregados de macromoléculas, além de ser resistente às proteases e às amilases presentes nas porções superiores do trato gastrintestinal (TGI), sendo degradada por enzimas produzidas pela microbiota colônica 44,50,57 .…”

Section: Pectinaunclassified

“…Além disso, surgiu um grande interesse na utilização da pectina na engenharia de tecidos, principalmente devido à semelhança química desse material com a matriz extracelular de tecidos dos mamíferos 54,70 . Desta forma, géis de pectina têm sido empregados no desenvolvimento de scaffolds para aplicações em tecido ósseo a fim de estimular a regeneração e promover sua reconstrução 44,70 .…”

Section: Pectinaunclassified

See 3 more Smart Citations

Biopolímeros: aplicações farmacêutica e biomédica

et al. 2016

View full text Add to dashboard Cite

____________________________________________________________________________Resumo: O estudo e desenvolvimento de polímeros para aplicação nas áreas biomédica e farmacêutica têm aumentado devido às suas propriedades peculiares que contribuem para a melhoria da qualidade de vida, como por exemplo, os polímeros usados em medicina regenerativa e sistemas de liberação de fármacos. O desenvolvimento de novos materiais baseados em polímeros depende desde os métodos de síntese, extração ou composição desses materiais até os estudos da influência de suas estruturas e propriedades em aplicações específicas, entre outras. Esta revisão descreve o uso de alguns de polímeros novos e convencionais com potencial para aplicação nas áreas farmacêutica e biomédica, enfatizando as principais propriedades que os tornam aplicáveis. Palavras-chave: biopolímero, medicina regenerativa, liberação de fármacos ____________________________________________________________________________ Abstract:The study and development of polymers for pharmaceutical and biomedical use has been increasing due to their peculiar properties that contribute for the improvement of the life quality, such as the polymers used in regenerative medicine and in drug release systems. The development of new polymer based materials and its composites depends on several steps, such as the synthesis approach, the extraction, the composition, the influence of their properties on the specific applications, and others. This review describes the use of conventional and new polymers with potential application in pharmaceutical and biomedical fields, highlighting the properties that allow them to be useful for such purposes.

show abstract

Section: Pectinaunclassified

“…De acordo com o DE, as pectinas são divididas em duas classes: pectinas de alto grau de metoxilação, quando DE > 50%, e pectinas de baixo grau de metoxilação, com um DE < 50% 44,58 .…”

Section: Pectinaunclassified

See 2 more Smart Citations

Biopolímeros: aplicações farmacêutica e biomédica

et al. 2016

View full text Add to dashboard Cite

show abstract

“…CMSP is prepared through etherification of the hydroxyl groups with sodium monochloroacetate (SMCA) which is used as an etherifying agent, based on Williamson's ether synthesis . Previous studies have demonstrated the formation of hydrogels by cross‐linking CMSP using electron beam (EB) . Besides, it has also been cross‐linked with another natural polymer such as pectin to form hydrogel for controlled drug delivery .…”

Section: Introductionmentioning

confidence: 99%

Carboxymethyl sago pulp/carboxymethyl sago starch hydrogel: Effect of polymer mixing ratio and study of controlled drug release

Tan

Wong

Muniyandy

et al. 2016

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

Carboxymethyl sag o pulp (CMSP)/carboxymethyl sago starch (CMSS) hydrogel was synthesized by electron beam irradiation. In the series of hydrogels prepared, 40%/20% CMSP/CMSS hydrogel had the highest gel fraction. The swelling capacity of CMSP/CMSS hydrogel was found to be highest in distilled water, followed by pH 11, pH 7.4, and pH 1.2. Scanning Electron Microscope photographs revealed that the drug-loaded hydrogel had a smoother surface than unloaded hydrogel. Fourier Transform Infrared and Differential Scanning Calorimetry analysis showed the absence of interaction between the hydrogels and the drug. All drugloaded hydrogels had drug encapsulation efficiency between 63% and 69%. CMSP/CMSS hydrogel swelled and allowed the release of drug at pH 7.4. These properties qualify the hydrogel as a potential candidate for controlled drug release at the ocular and colonic regions.

show abstract

Dual crosslinked carboxymethyl sago pulp/pectin hydrogel beads as potential carrier for colon‐targeted drug delivery

Tan

Wong

et al. 2016

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

Carboxymethyl sago pulp (CMSP)/pectin hydrogel beads were synthesized by calcium crosslinking and further crosslinked by electron beam irradiation to form drug carrier for colon-targeted drug. Sphere-shaped CMSP/pectin 15%/5% hydrogel beads is able to stay intact for 24 h in swelling medium at pH 7.4. It shows pH-sensitive behavior as the swelling degree increases as pH increases. Fourier transform infrared spectroscopy analysis confirmed the absence of chemical interaction between hydrogel beads and diclofenac sodium. Differential scanning calorimetric and X-ray diffraction studies indicate the amorphous nature of entrapped diclofenac sodium. The drug encapsulation efficiency is up to about 50%. Less than 9% of drug has been released at pH 1.2 and the hydrogel beads sustain the drug release at pH 7.4 over 30 h. This shows the potential of CMSP/pectin hydrogel beads as carrier for colon-targeted drug.

show abstract

Radiation cross-linked carboxymethyl sago pulp hydrogels loaded with ciprofloxacin: Influence of irradiation on gel fraction, entrapped drug and in vitro release

Cited by 24 publications

References 38 publications

Biopolímeros: aplicações farmacêutica e biomédica

Biopolímeros: aplicações farmacêutica e biomédica

Carboxymethyl sago pulp/carboxymethyl sago starch hydrogel: Effect of polymer mixing ratio and study of controlled drug release

Dual crosslinked carboxymethyl sago pulp/pectin hydrogel beads as potential carrier for colon‐targeted drug delivery

Contact Info

Product

Resources

About