Radiation Dosimetry of the<sup>131</sup>I-Hippuran Renogram

Henk, J.M.; Cottrall, M. F.; Taylor, David

doi:10.1259/0007-1285-40-473-327

Cited by 21 publications

(4 citation statements)

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“…The radiation dose from 10 pCi 1311-Hippuran after 3 hours' retention in the bladder is 190 mrem to the thyroid gland blocked with iodine, and 78 mrem to the bladder (Henk et al, 1967). This is well within the prescribed limits of the International Committee for Radiation Practices, 1965.…”

Section: Indicators and Instrumentationsupporting

confidence: 59%

Estimation of Residual Urine Volume with¹³¹I-Hippuran

Barnard

Bastable

Richards

1973

British Journal of Urology

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Summary The use of 1311‐Hippuran for the determination of the residual urine volume has been studied. It has been shown that a significant error is introduced into residual urine calculation by the small amounts of 1311‐Hippuran which continue to be excreted in the urine for some hours after intravenous injection, even when renal function is good. The rise in activity over the bladder area appears to be linear with time in individual patients, but the slope is unpredictable. True residual urine volume can be calculated if readings of the activity in the bladder area and at the background site are taken at a short, measured interval after voiding, and again 30 minutes later. The use of such a corrective calculation has a number of practical advantages, and makes the determination more accurate. The activity measured over the umbilicus with the patient supine appears to give a satisfactory tissue background reading.

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Section: Indicators and Instrumentationsupporting

confidence: 59%

Estimation of Residual Urine Volume with¹³¹I-Hippuran

Barnard

Bastable

Richards

1973

British Journal of Urology

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“…First, radiation dosage is very much reduced, a point of particular importance for studies in children. A 40pCi dose of 1311-labelled Hippuran would be expected to give a radiation dose to the whole body of less than 12 mrem (Henk, Cottrall & Taylor, 1967), which could be further reduced by prior removal of free iodide from the Hippuran, or prior blocking of the thyroid. To this dosage a further 10 pCi of 13'I-labelled albumin would add 35 mrem (Hall & Monks, 1966).…”

Section: Discussionmentioning

confidence: 99%

Quantitative Radioisotope Renography: The Derivation of Physiological Data by Deconvolution Analysis Using a Single-Injection Technique

Reeve

Crawley

1974

Clinical Science

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S U M M A R Y1. An improved method is presented for quantifying all the information relating to individual kidney function that is contained in the renogram.2. From the convolution theorem, functions are derived which are equivalent to the renograms that would be obtained by simultaneous injections of the indicator into each renal artery, fractionated according to renal blood flow.3. The 'pulse-input' renograms so derived can have the blood background subtracted by a process of 'kinetic discrimination', which dispenses with the prior injection of human serum albumin.4. The 'pulse-input' renograms with blood background subtracted are analysed by the techniques used in conventional indicator dilution methods.5. The value of this approach in clinical and experimental work is illustrated by comparison of examples drawn from 400 consecutive studies of patients with normal data.

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“…Most of the radioactivity administered is retained in the thyroid due to free iodide unless thyroid uptake is blocked by prior administration of unlabelled potassium iodide. The whole body dose of radiation from 11111-hippuran is about 2m Rem/10 ,uCi (Henk, Cottrall & Taylor, 1967). Radiation dosage using these techniques is less than 5% of that from an IVP.…”

Section: Radiolabelled Hippuranmentioning

confidence: 99%

Methods for the assessment of the effects of drugs on renal blood flow.

Pearson

1979

Brit J Clinical Pharma

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Radiation Dosimetry of the¹³¹I-Hippuran Renogram

Cited by 21 publications

References 10 publications

Estimation of Residual Urine Volume with¹³¹I-Hippuran

Estimation of Residual Urine Volume with¹³¹I-Hippuran

Quantitative Radioisotope Renography: The Derivation of Physiological Data by Deconvolution Analysis Using a Single-Injection Technique

Methods for the assessment of the effects of drugs on renal blood flow.

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Radiation Dosimetry of the131I-Hippuran Renogram

Cited by 21 publications

References 10 publications

Estimation of Residual Urine Volume with131I-Hippuran

Estimation of Residual Urine Volume with131I-Hippuran

Quantitative Radioisotope Renography: The Derivation of Physiological Data by Deconvolution Analysis Using a Single-Injection Technique

Methods for the assessment of the effects of drugs on renal blood flow.

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Product

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Radiation Dosimetry of the¹³¹I-Hippuran Renogram

Estimation of Residual Urine Volume with¹³¹I-Hippuran

Estimation of Residual Urine Volume with¹³¹I-Hippuran