“…High-density irradiation induced defect clusters, such as dislocation loops and networks, voids, bubbles, and stacking fault tetrahedra (SFTs), can significantly undermine the mechanical properties of irradiated materials in form of irradiation hardening, embrittlement, etc. − Next-generation nuclear reactors call for exploration of advanced structural materials that can sustain extreme radiation up to several hundred displacements-per-atom (dpa). , Nanostructured materials, such as nanocrystalline, nanolayered, nanoporous (np), and nanotwinned (nt) materials, have high-density defect sinks that can alleviate radiation damage. Fine grained materials have shown significantly reduced defect density and radiation induced hardening. − Grain boundary affected zones have been observed in various nanomaterials where defect clusters migrate toward grain boundaries swiftly before being absorbed.…”