We propose that a Floquet Weyl semimetal state can be induced in three-dimensional topological insulators, either nonmagnetic or magnetic, by the application of off-resonant light. The virtual photon processes play a critical role in renormalizing the Dirac mass and so resulting in a topological semimetal with vanishing gap at Weyl points. The present mechanism via off-resonant light is quite different from that via on-resonant light, the latter being recently suggested to give rise to a Floquet topological state in ordinary band insulators. [8][9][10] has partly gained success; however, candidate materials for TIs are still very limited. Inspiringly, an intriguing method was put forward to realize topologically non-trivial phases in nonequilibrium by applying time-dependent perturbations to trivial phases [11][12][13][14][15][16]. Typical examples are the optically-activated anomalous Hall effect and spin Hall effect in n-doped paramagnetic semiconductors [14], and the so-called Floquet topological insulator (FTI) suggested by Lindner, Refael, and Galitski [16], whose quasienergy spectrum exhibits a single pair of helical edge states due to the on-resonant-light-induced band inversion. In the bulk FTI spectrum there is an avoided crossing separating the reshuffled valence band from the conduction band.