Radiation esophagitis in the opossum: Radioprotection with indomethacin

Analysing the role of COX-2 in acute oesophagitis and in melatonin-exerted protection against experimental reflux oesophagitis in rats

“…It was noted that dmPGE 2 intake in RE‐rats amplified the MPO activity and tissue damage compared with untreated RE‐rats, which complements our interpretations that COX‐2 activation resulting in increased PGE 2 production, in fact, augments oesophageal inflammation and adds to tissue injury. In agreement with our findings, Northway et al ., demonstrated in the opossum model, that administration of a prostaglandin analogue before oesophageal insult accelerated the resultant inflammation [23] . Further, estimation of PGE 2 levels after dmPGE 2 systemic administration in RE‐rats revealed that dmPGE 2 actually increased its own synthesizing inducible COX‐2 expression and thereby PGE 2 level in the oesophagus, thus signifying that COX‐2 activation may be the underlying mechanism via which it aggravated tissue damage in RE‐rats.…”

Healing action of topical chamomile on 5-fluouracil induced oral mucositis in hamster

“…Efforts are directed toward the continued quest for new treatments for mucositis [18,26,35]. The action of alternative/natural agents has been investigated, and a few studies have assessed vitamin A [15], vitamin E [7], vitamin B12 [2], folate, dietary supplements [2], glutamine [27], and aloe [36].…”

Role of Platelet-Activating Factor in Acid-Induced Esophageal Mucosal Injury

“…The esophageal squamous mucosa metabolizes arachidonic acid via both the cyclooxygenase and the 5-lipoxygenase pathway, but unlike the gastric mucosa, it has been reported that these metabolites play a different role with regard to esophageal mucosal defense and inflammation [17][18][19][20][21]. Acid-induced esophagitis has been reported to be inhibited by pretreatment with the cyclooxygenase inhibitor indomethacin and healing of experimental esophagitis is also enhanced by this drug [19,21].…”