Radiation exposure of patients undergoing whole-body FDG-PET/CT examinations

Brix, Gunnar; Noßke, D.; Lechel, Ursula

doi:10.3413/nukmed-0663-14-04

Cited by 34 publications

(32 citation statements)

References 5 publications

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“…There is a demand on the use of PET-CT scan due to its benefits. However, the disadvantage of these technologies is patients who undergo PET-CT examination will expose to dual radiation generated by both CT and PET scanners [12].…”

Section: Introductionmentioning

confidence: 99%

“…Radiopharmaceutical of 18 F-FDG is well known and widely use in clinical PET imaging. It produced by the bombardment from the cyclotron [12].…”

Section: Introductionmentioning

confidence: 99%

“…where DT is the absorbed doses to a tissue or organ, T, A is the activity (MBq) of 18 F-FDG administered to the patient and Γ is dose coefficient provided by ICRP 106 for a variety of organs and tissues of the adult MIRD phantom [12,17] The effective dose, E received by patients were evaluated based on equation (2).…”

mentioning

confidence: 99%

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The effective dose result of¹⁸F-FDG PET-CT paediatric patients

Hussin

Said

Ali

et al. 2017

J. Phys.: Conf. Ser.

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Abstract. Paediatric patient received high exposure from both CT and PET examination. Automatic Exposure Control (AEC) is important in CT dose reduction. This study aimed to compare the effective dose obtained from PET-CT scanner with and without the use of AEC function. In this study, 68 patients underwent PET-CT examination without the use of AEC function, while 25 patients used the AEC function during the examination. Patients involved in this study were between 2 to 15 years old with varies of malignancies and epilepsy diseases.The effective dose obtained from PET and CT examinations was calculated based on recommendation from International Commission on Radiological Protection (ICRP) Publication 106 and ICRP publication 102. The outcome of this study shows that the radiation dose was reduced up to 20% with the use of AEC function. The mean average of effective dose result obtained from PET and CT examinations without the use of AEC and AEC function were found to be as 6.67 mSv, 6.77 mSv, 6.03mSv and 4.96 mSv respectively. Where total effective dose result of PET-CT with non-AEC and AEC were found to be 13.44 mSv and 10.99 mSv respectively. Conclusion of this study is, the installation of AEC function in PET-CT machine does play important role in CT dose reduction especially for paediatric patient.

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Section: Introductionmentioning

confidence: 99%

“…Radiopharmaceutical of 18 F-FDG is well known and widely use in clinical PET imaging. It produced by the bombardment from the cyclotron [12].…”

Section: Introductionmentioning

confidence: 99%

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The effective dose result of¹⁸F-FDG PET-CT paediatric patients

Hussin

Said

Ali

et al. 2017

J. Phys.: Conf. Ser.

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“…The combined image is clearer rather than a single scan of CT or PET and it helps physician to make decisions [11]. It is an issue where, by undergoing PET/CT scan, children especially are exposed to dual radiation which were generated by CT and PET itself [12]. Effective dose is a quantity as defined in ICRP Publication [13] as a weighted sum of equivalent doses to all relevant tissues and organ.…”

Section: Introductionmentioning

confidence: 99%

“…Radiopharmaceutical F18 FDG is widely use in terms of positron emitting in clinical PET. It is produced by the bombardment from the cyclotron [12].…”

Section: Introductionmentioning

confidence: 99%

Radiation assessment to paediatric with F-18-FDG undergo whole-body PET/CT examination

Dhalisa¹,

Mohamad²,

Rafidah³

2016

AIP Conference Proceedings

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A simple low-cost of liquid I-131 dispenser for routine radiopharmaceutical dispensing at nuclear medicine department, Institut Kanser Negara AIP Conference Proceedings 1704, 030002 (2016) Abstract. This study was carried out on wholebody radiation dose assessment to paediatrics patient who undergo PET/CT scanner at Institut Kanser Negara. Consist of 68 patients with varies of malignancies and epilepsy disease case covering age between 2 years to 12 years old. This is a retrospective study from 2010-2014. The use of PET/CT scanner as an advanced tool has been proven to give an extra radiation dose to the patient. It is because of the radiation exposure from the combination of both CT and PET scans rather than a single CT or PET scan. Furthermore, a study on radiation dose to paediatric patient undergoing PET/CT is rare in Malaysia. So, the aim of this study is to estimate the wholebody effective dose to paediatric patient in Malaysia. Effective dose from PET scan was calculated based on the activity of F18 FDG and dose coefficient reported in International Commission on Radiological Protection (ICRP) Publication 106. Effective dose from CT was determined using k coefficient as reported in ICRP publication 102 and Dose Length Product (DLP) value. The average effective dose from PET and CT were found to be 7.05mSv and 5.77mSv respectively. The mean wholebody effective dose received by a patient with combined PETCT examination was 12.78mSv. These results could be used as reference for dosimetry of a patient undergoing PETCT examination in Malaysia.

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How to scan who: the delicate balance between selecting the patient and selecting the imaging protocol

Hustinx

2016

Eur J Nucl Med Mol Imaging

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In this issue of the EJNMMI, Spadafora et al. propose shortening the FDG PET/CT acquisition for evaluating a solitary pulmonary nodule. The rationale is to design a strategy with a better cost-effectiveness ratio. There is a lot to like in the paper, as it discusses various aspects highly relevant to clinical nuclear medicine, such as clinical impact, patients' selection, imaging methodology, radiation safety, and costs. The objective is quite ambitious, as the proposed strategy could increase the number of FDG PET/CT performed for characterizing lung nodules, improve its effectiveness while reducing the cost and the radiation burden, and finally, increase the diagnostic accuracy. While some of these objectives may very well be achieved through this new strategy, it appears difficult to reach all, and there remain many question marks preventing the straight passage from the idea to the routine implementation.The first issue is the patient's selection. The current guidelines essentially use two criteria for deciding whether FDG PET/CT is indicated: the size of the nodule and the pre-test probability. It is important to note that the strategies discussed here exclusively concern solid nodules. FDG PET/CT should be performed for characterizing nodules > 8 mm in diameter with a pretest probability of malignancy that is low to moderate (5-65 %) [1] or ≥ 10 % [2]. The European guidelines are more complex, as it is recommended that indeterminate SPNs should be assessed, in light of all relevant information, including patient, epidemiological and procedure-related factors by expert multidisciplinary boards who will apply criteria such as those proposed by the Fleischner Society, which recommends considering PET in lesions > 8 mm [3,4]. In patients with a very high risk of cancer, the indication becomes staging rather than characterization [1]. Spadafora et al. imply that wholebody imaging is not indicated in T1 tumours, thanks to the low incidence of distant metastases in these early-stage lesions. This contradicts every international guideline for staging lung cancer [5][6][7], including small-cell lung cancer [8]. Indeed, even though lung cancer is increasingly diagnosed at an earlier stage, the majority of NSCLC patients have distant metastases at the time of diagnosis [9]. Even though the occurrence and distribution of distant metastases may occur following specific patterns, it remains practically impossible to predict such occurrence in individual patients [10]. Even in T1 tumors, the incidence of metastases is not negligible, as M1 disease has been reported in 13-14 % of the cases [11,12]. It is of primary importance that these patients are correctly identified in order to receive the optimal treatment, which may lead to prolonged survival in a subgroup presenting with synchronous oligometatastic NSCLC, i.e. with maximum five metastatic lesions [13]. PET/CT won't recognize all distant lesions, in particular the brain is not appropriately explored with PET alone. However, although the exact figure of extracerebral...

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Radiation exposure of patients undergoing whole-body FDG-PET/CT examinations

Abstract: The updated dose coefficients provide a valuable tool to easily assess the generic radiation risk of patients undergoing whole-body PET/CT (or PET/MRI) examinations and can be used, amongst others, for protocol optimization.

Cited by 34 publications

References 5 publications

The effective dose result of¹⁸F-FDG PET-CT paediatric patients

The effective dose result of¹⁸F-FDG PET-CT paediatric patients

Radiation assessment to paediatric with F-18-FDG undergo whole-body PET/CT examination

How to scan who: the delicate balance between selecting the patient and selecting the imaging protocol

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Radiation exposure of patients undergoing whole-body FDG-PET/CT examinations

Abstract: The updated dose coefficients provide a valuable tool to easily assess the generic radiation risk of patients undergoing whole-body PET/CT (or PET/MRI) examinations and can be used, amongst others, for protocol optimization.

Cited by 34 publications

References 5 publications

The effective dose result of18F-FDG PET-CT paediatric patients

The effective dose result of18F-FDG PET-CT paediatric patients

Radiation assessment to paediatric with F-18-FDG undergo whole-body PET/CT examination

How to scan who: the delicate balance between selecting the patient and selecting the imaging protocol

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Product

Resources

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The effective dose result of¹⁸F-FDG PET-CT paediatric patients

The effective dose result of¹⁸F-FDG PET-CT paediatric patients