Radiation exposure of the heart, lung and skin by radiation therapy for breast cancer: A dosimetric comparison between partial breast irradiation using multicatheter brachytherapy and whole breast teletherapy

Lettmaier, Sebastian; Kreppner, Stephan; Lotter, Michael; Walser, M.; Ott, Oliver J.; Fietkau, Rainer; Strnad, Vratislav

doi:10.1016/j.radonc.2010.07.011

Cited by 77 publications

(43 citation statements)

References 26 publications

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“…WBI is associated with increased cardiac mortality for left-sided breast cancer, raising interest in cardiac doses with PBI (4,12,20). This study found the heart max 2 cc and heart V 5 are reduced with ML-MS when compared with the standard plan in a single catheter as a result of optimizing the ML-MS plans to reduce the rib dose.…”

Section: Discussionmentioning

confidence: 82%

“…PBI targets the tumor bed (area at the highest risk of relapse), sparing more distant tissue from high dose, with the intention of reducing normal tissue side effects and maintaining local control. Multi-catheterebased interstitial brachytherapy has been used for many years but its relative complexity limits its use to a few centers (4). MammoSite (Hologic, Inc., Bedford, MA) brachytherapy (MSB) has been introduced as a simple implantation, treatment planning and delivery method for PBI.…”

Section: Introductionmentioning

confidence: 99%

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Optimization and comparison of balloon-based partial breast brachytherapy using a single source, a standard plan line source, and both forward and inverse planned multilumen techniques

et al. 2013

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Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Optimization and comparison of balloon-based partial breast brachytherapy using a single source, a standard plan line source, and both forward and inverse planned multilumen techniques

et al. 2013

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“…Therefore averagely, 37.2% of CTV (highest risk CTV, according to needle placement within the tumor bed) received 64 Gy (arm one) and 76.6 Gy (arm two), and higher EQD 2 dose. On the other hand, APBI by multicatheter interstitial brachytherapy allows significant decrease of radiation exposure of organs at risk in comparison to whole breast EBRT three to four fold [32, 33, 35]. …”

Section: Resultsmentioning

confidence: 99%

High-dose-rate interstitial brachytherapy for accelerated partial breast irradiation – trial results of Azerbaijan National Center of Oncology

Aliyev¹,

Isayev²,

Akbarov³

et al. 2017

jcb

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PurposeTo describe early results of two cohorts of patients with low and intermediate risk of early breast cancer treated with accelerated partial breast irradiation (APBI) using different schedules of multicatheter brachytherapy.Material and methodsPatients with early stage breast cancer after breast conserving surgery were enrolled for a prospective analysis. The APBI, using multicatheter brachytherapy, was delivered either eight times 4 Gy in five days with a planned total dose of 32 Gy, or seven times 5 Gy in four days with a planned total dose of 35 Gy. Primary endpoints were side effects.ResultsForty-eight patients were enrolled between 2012 and 2014. Patients characteristics were as follow: median age of patients was 55 years, early breast cancer was defined according GEC-ESTRO recommendations. With a median follow-up period of 37 months, no significant differences regarding late side effects and cosmesis between two cohorts of patients were documented. In total, cosmesis was excellent in 13/48 (27.1%) patients, good in 34/48 (70.8%) patients, and moderate in 1/48 patient (2.1%).ConclusionsAccelerated partial breast irradiation using multicatheter brachytherapy with 32 Gy/8 fractions and 35 Gy/7 fractions for early breast cancer seems to be similar in terms of late side effects. According to our findings, APBI was also feasible for intermediate-risk of early breast cancer patients.

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“…In a paper of Lettmaier et al . [43], dose to 1 cm 3 and 0.1 cm 3 of skin volume with 5 mm thickness were reported. Gifford et al .…”

Section: Discussionmentioning

confidence: 99%

Treatment planning for multicatheter interstitial brachytherapy of breast cancer – from Paris system to anatomy-based inverse planning

Major

Polgár

2017

jcb

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In the last decades, treatment planning for multicatheter interstitial breast brachytherapy has evolved considerably from fluoroscopy-based 2D to anatomy-based 3D planning. To plan the right positions of the catheters, ultrasound or computed tomography (CT) imaging can be used, but the treatment plan is always based on postimplant CT images. With CT imaging, the 3D target volume can be defined more precisely and delineation of the organs at risk volumes is also possible. Consequently, parameters calculated from dose-volume histogram can be used for quantitative plan evaluation. The catheter reconstruction is also easier and faster on CT images compared to X-ray films. In high dose rate brachytherapy, using a stepping source, a number of forward dose optimization methods (manual, geometrical, on dose points, graphical) are available to shape the dose distribution to the target volume, and these influence dose homogeneities to different extent. Currently, inverse optimization algorithms offer new possibilities to improve dose distributions further considering the requirements for dose coverage, dose homogeneity, and dose to organs at risk simultaneously and automatically. In this article, the evolvement of treatment planning for interstitial breast implants is reviewed, different forward optimization methods are discussed, and dose-volume parameters used for quantitative plan evaluation are described. Finally, some questions of the inverse optimization method are investigated and initial experiences of the authors are presented.

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Radiation exposure of the heart, lung and skin by radiation therapy for breast cancer: A dosimetric comparison between partial breast irradiation using multicatheter brachytherapy and whole breast teletherapy

Cited by 77 publications

References 26 publications

Optimization and comparison of balloon-based partial breast brachytherapy using a single source, a standard plan line source, and both forward and inverse planned multilumen techniques

Optimization and comparison of balloon-based partial breast brachytherapy using a single source, a standard plan line source, and both forward and inverse planned multilumen techniques

High-dose-rate interstitial brachytherapy for accelerated partial breast irradiation – trial results of Azerbaijan National Center of Oncology

Treatment planning for multicatheter interstitial brachytherapy of breast cancer – from Paris system to anatomy-based inverse planning

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