Radiation exposure, protection and risk from nuclear medicine procedures

Salvatori, Massimo; Lucignani, Giovanni

doi:10.1007/s00259-010-1474-5

Cited by 10 publications

(4 citation statements)

References 20 publications

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“…At present, there are no guidelines to govern the levels of activity to be administered or the frequency of administrations, and treatment regimens are known to vary widely [9]. There is also dispute concerning the potential benefit of concomitant administration of chemo-radiosensitisers, and 131 I mIBG has been administered in conjunction with cisplatin [50], topotecan [7], and irinotecan [51]. It is likely that optimal administration protocols can only be identified in large-scale multi-centre trials.…”

Section: Discussionmentioning

confidence: 99%

EANM Dosimetry Committee series on standard operational procedures for internal dosimetry for 131I mIBG treatment of neuroendocrine tumours

et al. 2020

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The purpose of the EANM Dosimetry Committee Series on "Standard Operational Procedures for Dosimetry" (SOP) is to provide advice to scientists and clinicians on how to perform patient-specific absorbed dose assessments. This SOP describes image and data acquisition parameters and dosimetry calculations to determine the absorbed doses delivered to whole-body, tumour and normal organs following a therapeutic administration of 131 I mIBG for the treatment of neuroblastoma or adult neuroendocrine tumours. Recommendations are based on evidence in recent literature where available and on expert opinion within the community. This SOP is intended to promote standardisation of practice within the community and as such is based on the facilities and expertise that should be available to any centre able to perform specialised treatments with radiopharmaceuticals and patient-specific dosimetry. A clinical example is given to demonstrate the application of the absorbed dose calculations.

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Section: Discussionmentioning

confidence: 99%

EANM Dosimetry Committee series on standard operational procedures for internal dosimetry for 131I mIBG treatment of neuroendocrine tumours

et al. 2020

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“…Some of the recent developments in PET‐CT are that its radiation dose, which receives a major contribution from CT, is reduced. Although, PET and CT being combined together has caused a significant increase in the radiation dose given to the patient . This issue was addressed by Tonkopi et al and they proved that the radiation can be reduced from a whopping 8.1 mSv to 5.5 mSv, without a great deal of difference in the image quality.…”

Section: Hybrid Imaging Modalities In Actionmentioning

confidence: 99%

The Advents of Hybrid Imaging Modalities: A New Era in Neuroimaging Applications

et al. 2017

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Hybrid Imaging modalities have shown great potential in medical imaging and diagnosis. A more comprehensive and targeted view of neurological disorders can be achieved by blending the anatomical and functional perspectives through hybridization. With consistently improving technologies, there have been many developments in fused imaging techniques over the past few decades. This article provides an overview of various bimodal and trimodal hybrid imaging techniques being developed and explored for neuroimaging applications. Recent advancements and potentials are discussed for single photon emission computed tomography‐computed tomography (SPECT‐CT), positron emission tomography‐CT (PET‐CT), PET‐magnetic resonance imaging (PET‐MRI), electroencephalography‐functional magnetic resonance imaging (EEG‐fMRI), magnetoencephalography‐fMRI (MEG‐fMRI), EEG‐near‐infrared spectroscopy (EEG‐NIRS), magnetic resonance‐PET‐EEG (MR‐PET‐EEG) and MR‐PET‐CT in the perspective of neuroimaging. A comparison of these hybrid approaches is provided on a single platform to analyze their performance on the basis of several common factors essential for imaging and analyzing neurological disorders and in vivo molecular processes. This article also provides an overview of recently developed advanced imaging technologies that are being hybridized with other imaging modalities and being explored as potential techniques for neuroscience. Novel approaches and clinical applications of hybrid neuroimaging are anticipated with inclusion of new technologies, better sensing capabilities, multimodal probes, and improved hybridization.

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“…Several recent reports have related radiation risk to medical imaging, typically CT but in some cases nuclear medicine (48)(49)(50)(51)(52)(53)(54)(55)(56)(57). Some reports specifically addressed exposure of pediatric patients (58)(59)(60).…”

Section: Evaluation Of Radiation Risk For Pediatric Nuclear Medicinementioning

confidence: 99%

Minimizing and Communicating Radiation Risk in Pediatric Nuclear Medicine

Fahey¹,

Treves²,

Adelstein³

2011

J Nucl Med

139

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The value of pediatric nuclear medicine is well established. Pediatric patients are referred to nuclear medicine from nearly all pediatric specialties including urology, oncology, cardiology, gastroenterology, and orthopedics. Radiation exposure is associated with a potential, small, risk of inducing cancer in the patient later in life and is higher in younger patients. Recently, there has been enhanced interest in exposure to radiation from medical imaging. Thus, it is incumbent on practitioners of pediatric nuclear medicine to have an understanding of dosimetry and radiation risk to communicate effectively with their patients and their families. This article reviews radiation dosimetry for radiopharmaceuticals and also CT given the recent proliferation of PET/CT and SPECT/CT. It also describes the scientific basis for radiation risk estimation in the context of pediatric nuclear medicine. Approaches for effective communication of risk to patients' families are discussed. Lastly, radiation dose reduction in pediatric nuclear medicine is explicated.

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Radiation exposure, protection and risk from nuclear medicine procedures

Cited by 10 publications

References 20 publications

EANM Dosimetry Committee series on standard operational procedures for internal dosimetry for 131I mIBG treatment of neuroendocrine tumours

EANM Dosimetry Committee series on standard operational procedures for internal dosimetry for 131I mIBG treatment of neuroendocrine tumours

The Advents of Hybrid Imaging Modalities: A New Era in Neuroimaging Applications

Minimizing and Communicating Radiation Risk in Pediatric Nuclear Medicine

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