The Advents of Hybrid Imaging Modalities: A New Era in Neuroimaging Applications

Nedumaran, Anu Maashaa; Mishra, Sachin; Pandarinathan, Ganesh; Archunan, ‪Govindaraju; Gulyás, Balázs

doi:10.1002/adbi.201700019

Cited by 17 publications

(16 citation statements)

References 80 publications

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“…In the case of PET‐CT modality, they are used sequentially whereas in the case of PET‐MRI, they used simultaneously. [ 276 ] In the case of PET‐CT, PET monitors metabolic activity and CT reconstructs hard tissue images. [ 276 ] It gives better localization, higher accuracy, low‐noise and shorter scan time.…”

Section: Biomedical Applications Of Mnpsmentioning

confidence: 99%

“…[ 276 ] In the case of PET‐CT, PET monitors metabolic activity and CT reconstructs hard tissue images. [ 276 ] It gives better localization, higher accuracy, low‐noise and shorter scan time. [ 276 ] It has been used for cancer diagnosis and dementia monitoring.…”

Section: Biomedical Applications Of Mnpsmentioning

confidence: 99%

“…[ 276 ] It gives better localization, higher accuracy, low‐noise and shorter scan time. [ 276 ] It has been used for cancer diagnosis and dementia monitoring. [ 276 ] However, in the case of PET‐MRI, MRI confirms soft tissue presence.…”

Section: Biomedical Applications Of Mnpsmentioning

confidence: 99%

“…[ 276 ] It has been used for cancer diagnosis and dementia monitoring. [ 276 ] However, in the case of PET‐MRI, MRI confirms soft tissue presence. MRI‐PET provides high spatial and temporal resolution, high sensitivity and no ionizing radiation.…”

Section: Biomedical Applications Of Mnpsmentioning

confidence: 99%

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Recent progress of magnetic nanoparticles in biomedical applications: A review

et al. 2021

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Magnetic nanoparticles (MNPs) offer tremendous potentialities in biomedical applications for a long while. Since these materials' interactions in biological media largely rely on their crystal structures, sizes, and shapes, detailed studies on their synthesis mechanism for medicinal aspects are crucial. Despite many review reports that have already been published on MNPs, they mainly have focused either on their perspective in biomedical applications or their synthesis and characterization along with functionalization mechanisms as individual entities. For this reason, this review uncovers a comprehensive insight into the ongoing improvement of fabrication processes, surface functionalization of MNPs for biomedical applications together. Besides, various magnetic nanocomposite (MNCs) for smart drug delivery, recent hyperthermia treatment, lab‐on‐a‐chip, and magnetic bio‐separation, and some of the recent emerging imaging techniques using MNPs are discussed. A detailed analysis of toxicity, challenges, and recent progress of clinical trials of MNPs is sketched out to open numerous entryways for advanced research on MNPs for biomedical applications.

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Section: Biomedical Applications Of Mnpsmentioning

confidence: 99%

Section: Biomedical Applications Of Mnpsmentioning

confidence: 99%

Section: Biomedical Applications Of Mnpsmentioning

confidence: 99%

Section: Biomedical Applications Of Mnpsmentioning

confidence: 99%

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Recent progress of magnetic nanoparticles in biomedical applications: A review

et al. 2021

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“…Fluorescence imaging has become one of the most popular bioimaging techniques due to its native merits of superb sensitivity, simplicity, high temporal resolution, rapid responsiveness, and maneuverability . As a key component in fluorescence imaging, the development of advanced fluorescent theranostic agents has emerged as one of the most exciting research fields to provide new opportunities for precise and personalized medical treatment of patients . An ideal fluorescent agent should have low toxicity, high brightness, excellent stability, good selectivity, and versatile functionality.…”

Section: Introductionmentioning

confidence: 99%

Unity Makes Strength: How Aggregation‐Induced Emission Luminogens Advance the Biomedical Field

et al. 2018

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research fields to provide new opportunities for precise and personalized medical treatment of patients. [16][17][18][19][20][21][22][23][24][25][26][27] An ideal fluorescent agent should have low toxicity, high brightness, excellent stability, good selectivity, and versatile functionality. To date, a vast variety of synthetic fluorescent materials, including organic dyes, [28][29][30] fluorescent proteins, [31,32] inorganic quantum dots (QDs), [33,34] conjugated polymer nanoparticles (NPs), [35][36][37][38][39][40] metallic nanoclusters, [41] as well as upconversion NPs, [42][43][44] have been explored and demonstrated for biological applications.Among the above-mentioned fluorescent materials, synthetic organic dyes and dye-loaded fluorescent NPs have attracted special attention due to the good biocompatibility and easy availability. However, a considerable number of organic dyes are hydrophobic, which often form aggregation through π-π stacking in aqueous solutions and buffers even though different strategies have been applied to improve their water solubility. The serious π-π stacking interactions among dye molecules facilitate nonradiative pathways to relax the exciton energy, leading to partially or completely quenched fluorescence. This phenomenon is well known as aggregation-caused quenching (ACQ) effect, [45] which is the main obstacle of construction of highly emissive fluorescence bioprobes in complicated biological microenvironments. Although great efforts have been made from various aspects to overcome the notorious undesired ACQ effect, [46] it remains a major challenge for the significant improvement of traditional fluorescent bioprobes in biomedicine and life sciences.In 2001, Tang and co-workers discovered a novel fluorescent phenomenon that is opposite to the ACQ effect: the organic Figure 4. Confocal images of Hela cancer cells after incubation with A-D) A6-A9 (5 × 10 −6 m) for 15 min, respectively. Adapted with permission. [104]

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A multi‐modality physical phantom for mimicking tumor heterogeneity patterns in PET/CT and PET/MRI

et al. 2022

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Background: Hybrid imaging (e.g., positron emission tomography [PET]/ computed tomography [CT],PET/magnetic resonance imaging [MRI]) helps one to visualize and quantify morphological and physiological tumor characteristics in a single study. The noninvasive characterization of tumor heterogeneity is essential for grading, treatment planning, and following-up oncological patients. However, conventional (CONV) image-based parameters, such as tumor diameter, tumor volume, and radiotracer activity uptake, are insufficient to describe tumor heterogeneities. Here, radiomics shows promise for a better characterization of tumors. Nevertheless, the validation of such methods demands imaging objects capable of reflecting heterogeneities in multi-modality imaging. We propose a phantom to simulate tumor heterogeneity repeatably in PET,CT,and MRI. Methods: The phantom consists of three 50-ml plastic tubes filled partially with acrylic spheres of S1: 1.6 mm, S2: 50%(1.6 mm)/50%(6.3 mm), or S3: 6.3-mm diameter. The spheres were fixed to the bottom of each tube by a plastic grid, yielding one sphere free homogeneous region and one heterogeneous (S1, S2, or S3) region per tube. A 3-tube phantom and its replica were filled with a fluorodeoxyglucose (18F) solution for test-retest measurements in a PET/CT Siemens TPTV and a PET/MR Siemens Biograph mMR system. A number of 42 radiomic features (10 first order and 32 texture features) were calculated for each phantom region and imaging modality. Radiomic features stability was evaluated through coefficients of variation (COV) across phantoms and scans for PET,CT,and MRI.Further,the Wilcoxon test was used to assess the capability of stable features to discriminate the simulated phantom regions. Results: The different patterns (S1-S3) did present visible heterogeneity in all imaging modalities. However, only for CT and MRI, a clear visual difference was present between the different patterns. Across all phantom regions in PET, CT, and MR images, 10, 16, and 21 features out of 42 evaluated features in total had a COV of 10% or less. In particular, CONV, histogram, and gray-level run length matrix features showed high repeatability for all the phantom regions and imaging modalities. Several of repeatable texture features allowed the image-based discrimination of the different phantom regions (p < 0.05). However, depending

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The Advents of Hybrid Imaging Modalities: A New Era in Neuroimaging Applications

Cited by 17 publications

References 80 publications

Recent progress of magnetic nanoparticles in biomedical applications: A review

Recent progress of magnetic nanoparticles in biomedical applications: A review

Unity Makes Strength: How Aggregation‐Induced Emission Luminogens Advance the Biomedical Field

A multi‐modality physical phantom for mimicking tumor heterogeneity patterns in PET/CT and PET/MRI

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