Radiation formation of hydrogels for biomedical purposes. Some remarks and comments

Rosiak, Janusz M.; Ulański, Piotr; Pajewski, Leonardo A.; Yoshii, Fumio; Makuuchi, Keizo

doi:10.1016/0969-806x(95)00007-k

Cited by 211 publications

(125 citation statements)

References 9 publications

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“…The results clearly demonstrate that when the thickness of the sample approaches the nanoscale, then it is seen that UVC radiation can be exploited as a through-thickness crosslinking technique. Consequently, nano-thick polymers may be crosslinked by UVC radiation analogous to samples many orders of magnitude thicker being crosslinked by high energy radiation like g-radiation, 15 or electron beams. As such, UVC radiation may find commercial application for crosslinking membranes formed by electrospinning that are used for biomedical applications.…”

Section: Effects Of Uvc Radiation On the Morphology And Chemical Strumentioning

confidence: 99%

Crosslinking neat ultrathin films and nanofibres of pH-responsive poly(acrylic acid) by UV radiation

et al. 2010

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Electrospun polyelectrolyte hydrogel nanofibres are being developed for many applications including artificial muscles, scaffolds for tissue engineering, wound dressings and controlled drug release. For electrospun polyelectrolytes, a post-spinning crosslinking process is necessary for producing a hydrogel. Typically, radiation or thermal crosslinking routines are employed that require multifunctional crosslinking molecules and crosslink reaction initiators (free radical producers). Here, ultraviolet subtype-C (UVC) radiation was employed to crosslink neat poly(acrylic acid) (PAA) nanofibres and films to different crosslink densities. Specific crosslink initiators or crosslinking molecules are not necessary in this fast and simple process providing an advantage for biological applications. Scanning probe microscopy was used for the first time to measure the dry and wet dimensions of hydrogel nanofibres. The diameters of the swollen fibres decrease monotonically with increasing UVC radiation time. The fibres could be reversibly swollen/contracted by treatment with solutions of varying pH, demonstrating their potential as artificial muscles. The surprising success of UVC radiation exposure to achieve chemical crosslinks without a specific initiator molecule exploits the ultrathin dimensions of the PAA samples and will not work with relatively thick samples. Crosslinking neat ultrathin films and nanofibres of pH-responsive poly(acrylic acid) by UV radiation Adrian Gestos, Philip G. Whitten, Geoffrey M. Spinks * and Gordon G. Wallace Electrospun polyelectrolyte hydrogel nanofibres are being developed for many applications including artificial muscles, scaffolds for tissue engineering, wound dressings and controlled drug release. For electrospun polyelectrolytes, a post-spinning crosslinking process is necessary for producing a hydrogel. Typically, radiation or thermal crosslinking routines are employed that require multifunctional crosslinking molecules and crosslink reaction initiators (free radical producers). Here, ultraviolet subtype-C (UVC) radiation was employed to crosslink neat poly(acrylic acid) (PAA) nanofibres and films to different crosslink densities. Specific crosslink initiators or crosslinking molecules are not necessary in this fast and simple process providing an advantage for biological applications. Scanning probe microscopy was used for the first time to measure the dry and wet dimensions of hydrogel nanofibres. The diameters of the swollen fibres decrease monotonically with increasing UVC radiation time. The fibres could be reversibly swollen/contracted by treatment with solutions of varying pH, demonstrating their potential as artificial muscles. The surprising success of UVC radiation exposure to achieve chemical crosslinks without a specific initiator molecule exploits the ultrathin dimensions of the PAA samples and will not work with relatively thick samples.

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Section: Effects Of Uvc Radiation On the Morphology And Chemical Strumentioning

confidence: 99%

Crosslinking neat ultrathin films and nanofibres of pH-responsive poly(acrylic acid) by UV radiation

et al. 2010

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“…Moreover, it is essential to mention that physical stimuli included temperature, electric field, solvent, light, pressure, sound and magnetic field, and so on (18). Among all physical cross-linking methods, the radiation technology has become popular for the preparation of hydrogel dressing due to some advantages: there are no side products such as wastes, sewage, fumes, and all the components used to manufacture the hydrogel dressings are safe and human friendly (19); moreover, the radiation technology is comparatively inexpensive and does not need extra laboratory setup (4). Even though there are many advantages in radiation technology the area of radiation processing on natural polymeric material largely remain unexplored as most of the biopolymers are degraded when exposed to radiation (20).…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Novel Medicated Hydrogels for Wound Dressing

Roy¹,

Saha²,

Kitano³

et al. 2010

Soft Materials

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□ The medicated hydrogels were prepared aseptically under moist heat treatment using polyvinylpyrrolidone (PVP), sodium-carboxymethylcellulose (CMC), polyethyleneglycol (PEG), agar, glycerin and/or boric acid (BA) and designated as PVP-CMC and PVP-CMC-BA. The aim of this study was to develop some medicinal values-based hydrogels. BA was used to build up the medicinal values (antiseptic and antimicrobial properties) within the hydrogels. Optical images, scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) spectroscopy of the hydrogels indicated that boric acid is uniformly dispersed within the cross-linked hydrogel network that may heal and protect the wounds from infections/sepsis. Swelling study in presence of water and physiological saline solution confirmed its reasonable absorption capacity. The rheological properties and mechanical properties demonstrated that the boric acid incorporated hydrogels are quite flexible. Assessment of antimicrobial property study proves that PVP-CMC-BA (3 % BA) has strong infection protection capacity.Keywords Boric acid, Hydrogels, Swelling, Viscoelastic properties, Wound dressing INTRODUCTIONThe medicated hydrogels are the hydrogels that possess some medicinal value within them. They are cross-linked polymeric gels that have water-holding and nonadhering properties. Hydrogels can be prepared with monomers, prepolymers, or existing hydrophilic polymers as starting materials. They are generally specified by two component systems. One of the components is hydrophilic, which has water insoluble three-dimensional polymer networks, and the second component is water. They may swell in water up to a large extent and reach the equilibrium state while retaining their original shape (1).In fact, a hydrogel is considered as a kind of cheap, effective, convenient material for wound dressing, due to its good biocompatibility, water absorption ability, moisture retention, and ventilating capacity (2). They are closely resembled to living tissue in their physical properties because of their relatively high water content as well as soft and rubbery consistency (3). Numerous research studies have established that a moist wound environment is most favorable for healing (4). Hydrogel wound burn dressings were first invented by Rosiak et al. in 1989, which have many interesting properties, such as immediate pain control, easy replacement, transparency, absorption, prevention of loss of body fluids, barrier against bacteria, good adhesion, easy handling, oxygen permeability, control of drug dosage, and so on (3,5,6).The hydrogel dressings are usually directly applied to the wounds, thus the biocompatibility and non-toxicity factors are required to be taken into consideration. Polyvinylpyrrolidone (PVP) is a well-known polymer with good biocompatibility; hence, this polymer can be used as one of the main components of pseudo hydrogel preparation for temporary skin covers or wound dressings (6, 7). PVP is used in production of medicines and serves as blood substitute and blood d...

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“…Radiation route offers a simpler, more efficient and cleaner process [10]. When an aqueous medium is irradiated with an ionizing radiation, absorption of the energy from the irradiation source will occur; this will then lead to formation of hydroxyl radicals, hydrogen atoms and solvated electrons in the medium.…”

Section: Radiation Crosslinkingmentioning

confidence: 99%

Preparation and characterization of polyethylene glycol diacrylate microgels using electron beam radiation

Hamzah¹,

Isa²,

Napia³

2014

AIP Conference Proceedings

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Abstract. The use of microemulsion in the development of nanosized gels based on polyethylene glycol diacrylate (PEGDA) is demonstrated. PEGDA was solubilized in n-heptane with use of sodium docusate (AOT) at 0.15M concentration to form reverse micelles. These micelles were than irradiated at 5, 10, 15, 20 and 25 kGy using electron beam (EB) to crosslink the entrapped polymer in the micelles. Ionizing radiation was imparted to the emulsions to generate crosslinking reaction in the micelles formed. The nanosized gels were evaluated in terms of particle diameter using dynamic light scattering (DLS) and the images of the nanosized gels were studied using transmission electron microscopy (TEM). Results show that the size and shape of the particles are influenced by concentration of PEGDA and radiation dose. This study showed that this method can be utilized to produce nanosized gels.

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Radiation formation of hydrogels for biomedical purposes. Some remarks and comments

Cited by 211 publications

References 9 publications

Crosslinking neat ultrathin films and nanofibres of pH-responsive poly(acrylic acid) by UV radiation

Crosslinking neat ultrathin films and nanofibres of pH-responsive poly(acrylic acid) by UV radiation

Development and Characterization of Novel Medicated Hydrogels for Wound Dressing

Preparation and characterization of polyethylene glycol diacrylate microgels using electron beam radiation

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