The paper presents numerical simulations of a fire in the Howard Street Tunnel, Baltimore, Maryland, following the derailment of a freight train in July, 2001. The model was validated for this application using temperature data collected during a series of fire experiments conducted in a decommissioned highway tunnel in West Virginia. The peak predicted temperatures within the Howard Street Tunnel were approximately 1,000 • C (1,800 • F) within the flaming regions, and approximately 500 • C (900 • F) averaged over a length of the tunnel equal to about four rail cars.