Radiation‐induced angiosarcoma of the rectum: a case report and review of literature

Ahmad, Ali; Jamieson, TA; Balsitis, M; Diament, R. H.

doi:10.1111/j.1463-1318.2008.01488.x

Cited by 17 publications

(7 citation statements)

References 4 publications

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“…Angiosarcoma can be located around an arteriovenous fistula or an area where persistent foreign substances are located [ 18 , 22 , 40 , 42 , 43 ]. Among the 33 primary colorectal angiosarcoma cases analyzed, 12% had a history of radiation exposure [ 2 , 7 , 8 , 19 ]. Radiation exposure for these patients was related to radiotherapy treatment for colorectal cancer, prostate cancer, cervical cancer, or endometrial cancer.…”

Section: Discussionmentioning

confidence: 99%

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Primary Colonic Angiosarcoma Seen in a Patient on Calcium Channel Blocker: A Case Report with Summary Analysis of 32 Other Cases from the Literature

Wang

Zhao

et al. 2018

Am J Case Rep

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Patient: Female, 54Final Diagnosis: Primary colonic angiosarcomaSymptoms: Rectal bleedingMedication: Levamlodipine BesylateClinical Procedure: HemicolectomySpecialty: Gastroenterology and HepatologyObjective:Rare co-existance of disease or pathologyBackground:Angiosarcoma is a rare malignant mesenchymal tumor of vascular endothelial cell origin. Its occurrence in the colorectal region is extremely rare. Only 32 cases of primary colorectal angiosarcoma are reported in the current literature. Angiosarcoma in association with calcium channel blocker has been rarely reported. We present such a case of a patient who had been on levamlodipine besylate, a calcium channel blocker, for over 10 years.Case Report:A 53-year-old female with hypertension presented with a fever, a dry cough, and hematochezia. Computed tomography (CT) scan and angiography demonstrated a 6-cm vascular mass in the ileocecal region. The clinical symptoms stopped soon after a right hemicolectomy. The histopathology with immunohistochemical studies confirmed the diagnosis of angiosarcoma. Three months after surgery, the patient had evidence of recurrence of the tumor, however, she no longer presented with a fever or a dry cough. The patient was receiving chemotherapy at the time of the report.Conclusions:Colorectal angiosarcoma is a rare malignancy of endothelial origin with uncertain etiology and often has a poor prognosis. Angiosarcoma seen in a patient taking calcium channel blocker is rare but alarming. CT scan and angiography are helpful tools to raise the suspicion of the diagnosis. A definitive pathological diagnosis relies on histopathology with immunohistochemical stains of endothelial markers. Surgical resection is still the best choice of the different treatment options.

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Section: Discussionmentioning

confidence: 99%

“…Thus, it generally carries a poor prognosis unless it is recognized early and treated properly. The etiology of angiosarcoma is uncertain [ 2 , 7 , 8 , 18 , 19 , 22 , 40 , 42 , 43 ]. Angiosarcoma has been rarely reported in a patient who takes calcium channel blocker to control blood pressure [ 48 , 49 ].…”

Section: Introductionmentioning

confidence: 99%

Primary Colonic Angiosarcoma Seen in a Patient on Calcium Channel Blocker: A Case Report with Summary Analysis of 32 Other Cases from the Literature

Wang

Zhao

et al. 2018

Am J Case Rep

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“…Histological demonstration of chronic granulomatous inflammation with caseation is pathognomonic of tuberculosis. Culture or demonstration of AFB in the biopsy specimen using Zhiehl-Nielson stain is the most specific test, although in most instances superficial biopsies may not reveal the bacilli [3] and only 36% of the cultures would yield a positive result [4]. Anorectal tuberculosis usually responds well to antitubercular drugs and these patients seldom require any further surgical intervention.…”

Section: Discussionmentioning

confidence: 99%

Rectal tuberculosis: A rare cause of recurrent rectal suppuration

Samarasekera

Nanayakkara

2008

Colorectal Disease

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Tuberculosis affecting the rectum is a rare extra-pulmonary form of the disease that needs recognition, because it requires specific treatment and avoids multiple, unwarranted surgical interventions. The following discussion is centred on a case of rectal tuberculosis, a disease that rarely affects the anorectal region. The condition was diagnosed on histology and was successfully treated medically with complete resolution.

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“…Other rare malignant spindle cell tumours described at this site include embryonal rhabdomyosarcoma, angiosarcoma, dermatofibrosarcoma protruberans, Kaposi's sarcoma, de‐differentiated liposarcoma, low‐grade fibromyxoid sarcoma, sarcomatoid/spindle cell carcinoma and sarcomatoid renal cell carcinoma …”

Section: Malignant Melanoma: Primary and Metastaticmentioning

confidence: 99%

Spindle cell proliferations of the sigmoid colon, rectum and anus: a review with emphasis on perineurioma

Grech

Schofield

2020

Histopathology

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A wide range of spindle cell proliferations are found uncommonly in the sigmoid colon, rectum and anus. They usually present as polyps, and include reactive lesions and benign and malignant neoplasms which may be primary or metastatic. They are less frequently described in the literature compared to those in the upper gastrointestinal tract, and may be underdiagnosed. The widespread use of sigmoidoscopy in symptomatic patients and bowel cancer screening programmes means that histopathologists must be aware of, and adopt a logical approach to, diagnosing spindle cell proliferations in biopsy and polypectomy specimens. This is particularly relevant given the strong association of some mesenchymal polyps with hereditary cancer syndromes. This review article will focus on perineurioma and the recent debate in relation to its overlap with fibroblastic polyp. The clinical, endoscopic, histological and immunohistochemical features of spindle cell proliferations which should be considered in the differential diagnosis of perineurioma will be discussed. There is also a brief reference to malignant spindle cell tumours of diagnostic importance.

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Radiation‐induced angiosarcoma of the rectum: a case report and review of literature

Abstract: We report a case of rectal angiosarcoma after prostatic radiotherapy, illustrating diagnostic difficulty. Awareness of this potential diagnosis is important with increasing use of radiotherapy in the treatment of pelvic cancers.

Cited by 17 publications

References 4 publications

Primary Colonic Angiosarcoma Seen in a Patient on Calcium Channel Blocker: A Case Report with Summary Analysis of 32 Other Cases from the Literature

Primary Colonic Angiosarcoma Seen in a Patient on Calcium Channel Blocker: A Case Report with Summary Analysis of 32 Other Cases from the Literature

Rectal tuberculosis: A rare cause of recurrent rectal suppuration

Spindle cell proliferations of the sigmoid colon, rectum and anus: a review with emphasis on perineurioma

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