Radiation-Induced Carcinoma of the Mastoid

Beal, David D.; Lindsay, John R.; Ward, Paul H.

doi:10.1001/archotol.1965.00750050014005

Cited by 30 publications

(8 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Radiation is one of the major factors that has been implicated in the etiology of middle-ear cancers. Eight carcinomas of the mastoid in 300 radium dial painters and cancer of the temporal bone after radiation therapy to the head and neck have been reported in previous studies (Beal et al, 1965;Rubin et al, 1977). There have been reports of experimentally induced squamous-cell carcinoma of the ear in rats given azoxymethane (Ward, 1975).…”

Section: Resultsmentioning

confidence: 92%

High prevalence of human papillomavirus types 16 and 18 in middle-ear carcinomas

Tsai

Jin

et al. 1997

Int. J. Cancer

View full text Add to dashboard Cite

Chronic suppurative otitis media, averaging 20 or more years of duration, has been associated with cancer in this region in 40%-80% of cases. Although human papillomaviruses (HPV) have been implicated in many human squamouscell neoplasms, their role in the pathogenesis of middle-ear malignancies remains unexplored. In this study, we investigated the presence and subtypes of HPV in middle-ear carcinomas. Formalin-fixed and paraffin-embedded tumor tissues were sampled for DNA extraction. PCR was done with consensus primers, capable of detecting HPV 16, 18, 31, 33, 52b and 58. Typing of the products generated by consensus primers was performed with restriction enzyme digestion. It was found that a resulting 89% (8/9) of the middle-ear carcinomas contained HPV DNA. Coexistence of HPV 16 and 18 was detected in 3 squamous-cell carcinomas. HPV 16 was detected in 4 squamous-cell carcinomas and 1 adenocarcinoma. The high prevalence of high-risk-type HPV in carcinomas of the middle ear suggests that viral infection may be an important etiologic component in the carcinogenic process.

show abstract

Section: Resultsmentioning

confidence: 92%

High prevalence of human papillomavirus types 16 and 18 in middle-ear carcinomas

Tsai

Jin

et al. 1997

Int. J. Cancer

View full text Add to dashboard Cite

show abstract

“…It will then be necessary to re¬ duce the hernia and cover it by both fascia and scalp flap. 4 8. Carotid artery thrombosis may occur from trauma or laceration of the internal carotid artery during the operative procedure.…”

Section: Operative Techniquementioning

confidence: 99%

Temporal Bone Resection: Review of 100 Cases

Lewis¹

1975

Archives of Otolaryngology - Head and Neck Surgery

112

View full text Add to dashboard Cite

“…RAMs have been defined as malignancies that occur within a prior radiation field, have histologic features distinct from those of the primary tumor, and occur at least 5 years after radiotherapy, although malignancies occurring 3 to 4 years after radiotherapy are also generally accepted to be RAMs . Sarcomas are classically associated with prior radiotherapy, but studies have found radiation‐associated squamous cell carcinomas (SCCAs) of the temporal bone are as well …”

Section: Introductionmentioning

confidence: 99%