Radiation-induced tumors and secondary malignancies following radiotherapy

Dedovic-Stojakovic, Jelena; Jovanovic, Luka; Filipovic, Predrag; Marinkovic, Tamara; Marinkovic, Mladen; Plesinac-Karapandzic, Vesna

doi:10.2298/vsp201210017d

Cited by 2 publications

(2 citation statements)

References 53 publications

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“…(41) After multidisciplinary treatment of Hodgkin lymphoma, patients are most often at risk of developing leukemia (e.g., acute myeloblastic leukemia) as well as solid tumors (most often cancers of the thyroid gland, breast, and bone sarcomas). Leukemia, which occurs in the first 4 to 10 years after treatment, is primarily associated with alkylating agents as part of chemotherapy protocols (42). As for non-hematological malignancies, breast cancer occurs most often with a standardized incidence of 56.7, followed by thyroid cancer with a standardized incidence of 36.1, followed by bone, colorectal, lung and stomach cancer.…”

Section: Acute and Late Toxicity Of Radiation Therapymentioning

confidence: 99%

Possibilities of radiotherapy in the treatment of pediatric Hodgkin lymphoma

Filipović,

Bokun,

Arsenijević

et al. 2024

Medicinska istraživanja

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Pediatric Hodgkin lymphoma is a malignant, lymphoproliferative disease of children and adolescents. Radiotherapy is an important form of treatment. The possibility of late toxicity of radiotherapy is a limiting factor in the application of radiotherapy as a treatment modality in pediatric patients. The technological progress of radiotherapy and the introduction of advanced radiotherapy techniques and proton therapy have improved the precision of radiotherapy and reduced the risk of long-term consequences. These technologies enabled targeted treatment, significantly reducing the exposure of healthy tissues and organs to radiation. All existing treatment recommendations and conducted cooperative studies have shown that radiation therapy is effective in the treatment of pediatric Hodgkin lymphoma, especially when combined with chemotherapy. On the other hand, there is the possibility of late toxicity to organs in growth and development, as well as the possibility of occurrence of secondary malignancies, which must be carefully considered when deciding on the implementation of radiotherapy. Radiation therapy represents an important therapeutic approach in the combined treatment of pediatric Hodgkin lymphoma. The combined therapeutic approach has improved treatment results, and advanced radiotherapy techniques will reduce the risk of side effects. Indications for the use of radiotherapy should be carefully evaluated in the treatment of pediatric patients with Hodgkin lymphoma.

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Section: Acute and Late Toxicity Of Radiation Therapymentioning

confidence: 99%

Possibilities of radiotherapy in the treatment of pediatric Hodgkin lymphoma

Filipović,

Bokun,

Arsenijević

et al. 2024

Medicinska istraživanja

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“…It is considered that the pediatric population has a tenfold risk for the development of induced malignancy than the adult population. Considering the long-term survival of patients treated for Ewing's sarcoma, frequent check-ups are necessary and should be carried out over a longer period of time (45).…”

Section: Adverse Effects Of R Adiother Apymentioning

confidence: 99%

The role of radiotherapy in the treatment of Ewing sarcoma of bone

Filipovic¹,

Popovic-Vukovic²,

Nikitović³

2023

Medicinska istraživanja

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Ewing sarcoma (ES) is the second most common primary bone malignancy after osteosarcoma. The disease most often occurs in adolescence, with peak incidence around the age of fourteen. The most common primary location of the tumor is the bones of the pelvis, followed by the ribs, spine and long bones of the extremities such as the tibia and the fibula. ES shows a tendency towards hematogenous dissemination, primarily in the lungs and bones, much less often lymphogenously. One third of patients have distant metastases present at initial diagnosis, which is why ES is considered a systemic disease. The treatment of Ewing sarcoma is based on a multimodal approach that includes the use of chemotherapy, surgery and/or radiotherapy. The identification of prognostic parameters enabled the individual treatment of patients based on the assessed risk group. With the application of modern therapeutic protocols, five-year survival for patients with localized disease lies between 60% and 68%, while for patients with metastatic disease, five-year survival is still unsatisfactory and is around 17%. ES belongs to the group of radiosensitive tumors, and radiotherapy plays a very important role in the local control of the disease, in combination with surgical treatment or independently, and can be applied as radical, preoperative or postoperative radiation therapy. Also, radiation therapy has a role in the palliative approach to the treatment of lung metastases and other metastatic sites. Considering that the modern multimodal treatment of Ewing sarcoma leads to long-term survival, it is necessary to take into account the expected side effects of the therapy that can reduce the quality of life of treated patients. Modern radiotherapy techniques such as three-dimensional conformal radiation therapy (3D CRT), intensity modulated radiation therapy (IMRT), volumetric modulated arc therapy (VMAT) enable precise delivery of the prescribed dose of radiation to target volumes with better sparing of surrounding normal tissues and organs, which leads to a lower incidence of late sequelae of radiation therapy and enables the preservation of the quality of life of treated patients.

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Radiation-induced tumors and secondary malignancies following radiotherapy

Abstract: nema

Cited by 2 publications

References 53 publications

Possibilities of radiotherapy in the treatment of pediatric Hodgkin lymphoma

Possibilities of radiotherapy in the treatment of pediatric Hodgkin lymphoma

The role of radiotherapy in the treatment of Ewing sarcoma of bone

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