Radiation-Induced World Health Organization Grade II Meningiomas in Young Patients Following Prophylactic Cranial Irradiation for Acute Lymphoblastic Leukemia in Childhood

Abstract

Current chemotherapeutic regimens have been used to successfully treat many children with acute lymphoblastic leukemia (ALL), but have resulted in an increased risk of late central nervous system tumors, most commonly meningioma, particularly in patients who have received cranial irradiation. We treated 3 young patients with World Health Organization grade II meningiomas who had previously received cranial irradiation for the treatment of childhood ALL: a cerebellopontine angle tumor in a 19-year-old woman, a petroclival tumor in a 28-year-old man, and a frontal parasagittal tumor in a 19-year-old woman. These cases were difficult to treat due to the aggressive and invasive biology of the tumors. Therefore, we recommend systematic cranial imaging and long follow-up periods for leukemia survivors to detect brain tumors before progression.

Severe course of radiation-induced meningioma — a new insight in screening for patients after radiotherapy?

“…The occurrence of meningioma among ALL radiotherapy receivers, after 25 years of follow-up, was estimated in one single-centre study as 21.4%, whereas the presence of neurological symptoms caused by brain lesions was 16.0%. However, the incidence appears to be significant, the idea of screening MRI among post-radiotherapy patients was rejected by the article authors because usual clinical symptoms appear at the early stage of meningioma [8], although other authors suggest a requirement of such a screening program [9]. Another study, based on victims of the nuclear bombing in Hiroshima, estimates the occurrence of meningioma as 14.9% after a 20-year follow-up [10].…”

Meningioma inducido por radiación en paciente que recibio tratamiento previo para el manejo de meduloblastoma: Reporte de caso

“…Por otro lado, el comportamiento de los RIM difiere de SM, los primeros tienden a ser más agresivo, de mayor grado (grado II y III según la clasificación de la OMS), con características histológicas atípicas/anaplásicas ya mencionadas anteriormente, crecimiento más rápido, mayores tasas de multiplicidad reportada alrededor de 4,6 a 29%, y recidiva, siendo el intervalo entre cirugía y de recurrencia de 6,2 años aproximadamente, principalmente aquellos pacientes que recibieron dosis altas de radiación 18,19 .…”