Radiation injury in surgical pathology

Berthrong, M; Fajardo, Luis F.

doi:10.1097/00000478-198103000-00006

Cited by 266 publications

(69 citation statements)

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“…The lesions in the intestine resemble those observed following irradiation and are likely caused by a block in cell proliferation in the crypts. 41,42 In the small intestine, stem cells in the base of the crypts give rise to progenitor cells that differentiate into enterocytes that migrate toward the tip of the villus and are shed. Diminished renewal of enterocytes leads to a reduction in the length of the villi.…”

Section: Discussionmentioning

confidence: 99%

Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis

Waning¹,

Li²,

Jia³

et al. 2008

Blood

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In vitro studies indicate that Cul4A ubiquitin ligases target for ubiquitin-mediated proteolysis regulators of cell-cycle progression, apoptosis, development, and DNA repair. In hematopoietic cell lines, studies by our group and others showed that Cul4A ligases regulate proliferation and differentiation in maturing myeloid and erythroid cells. In vivo, Cul4A-deficient embryos die in utero. Cul4A haploinsufficient mice are viable but have fewer erythroid and primitive myeloid progenitors. Yet, little more is known about Cul4A function in vivo. To examine Cul4A function in adults, we generated mice with interferon-inducible deletion of Cul4A. Cul4A deficiency resulted in DNA damage and apoptosis of rapidly dividing cells, and mutant mice died within 3 to 10 days after induction with dramatic atrophy of the intestinal villi, bone marrow, and spleen, and with hematopoietic failure. Cul4A deletion in vivo specifically increased cellular levels of the Cul4A ligase targets Cdt1 and p27Kip1 but not other known targets. Bone marrow transplantation studies with Cul4A deletion in engrafted cells specifically isolated analysis of Cul4A function to hematopoietic cells and resulted in hematopoietic failure. These recipients died within 9 to 11 days, demonstrating that in hematopoietic cells, Cul4A is essential for survival.

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Section: Discussionmentioning

confidence: 99%

Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis

Waning¹,

Li²,

Jia³

et al. 2008

Blood

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“…It is usually iatrogenic and unavoidable and frequently develops 6 mo to 5 years after regional radiotherapy for malignancy [1,2] . About half of all patients with malignancies undergo irradiation as part of their therapy.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in the management of radiation colitis

Kountouras¹,

Zavos²

2008

WJG

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“…Their weights were then recorded and they were killed by an overdose of nembutal. At this time, recovery of slight intestinal reactions could be expected while more marked reactions should still be clearly visible, due to incomplete recovery (2).…”

Section: -858 105mentioning

confidence: 89%

The Protective Effect of Intra-Arterial Vasopressin Injections on the Small Bowel During Fractionated Abdominal Irradiation A study in pigs

Borgström

et al. 1985

Acta Radiologica: Oncology

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Radiation injury in surgical pathology

Cited by 266 publications

References 0 publications

Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis

Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis

Recent advances in the management of radiation colitis

The Protective Effect of Intra-Arterial Vasopressin Injections on the Small Bowel During Fractionated Abdominal Irradiation A study in pigs

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