The Protective Effect of Intra-Arterial Vasopressin Injections on the Small Bowel During Fractionated Abdominal Irradiation A study in pigs

Borgström, S; Kf, Aronsen; Ne, Augustsson; Bjelkengren, Göran; Lindström, C; Nylander, G

doi:10.3109/02841868509134408

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Surgery1

Intra-arterial Vasopressin1

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2001

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Cited by 7 publications

(3 citation statements)

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“…As a useful consequence, this may reduce local tissue oxygenation and the potential for oxygen free radical formation following irradiation. Studies performed in the dog [48] and pig models [49] have demonstrated a radioprotective effect of vasopressin. To date however, no human trials have been published.…”

Section: Surgerymentioning

confidence: 98%

Radiation Enteritis

Horwhat¹,

Dubois

1999

Curr Treat Options Gastro

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Section: Surgerymentioning

confidence: 98%

Radiation Enteritis

Horwhat¹,

Dubois

1999

Curr Treat Options Gastro

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“…There was pres ervation of normal structure in the lymph nodes close to the small intestine and within the intestinal wall, which could counteract bacterial invasion in the intestinal wall fol lowing radiation treatment [12].…”

Section: Intra-arterial Vasopressinmentioning

confidence: 99%

Radiation and the Small Intestine

Churnratanakul

Wirzba

Lam

et al. 1990

Dig Dis

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“…Another use vasoconstrictive agents. These can be arterially with good protective effect (10)(11)(12). application of suitable vasoconstrictive agents surface of the intestinal mucosa is a further ility and studies on local application ephrine and sodium sulphite have shown promising sults (13,14).…”

mentioning

confidence: 99%

Radioprotective Effect of Local Administration of Lysine-Vasopressin and Triglycyl-Lysine-Vasopressin on the Rectal Mucosa in Rats

et al. 1995

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Reactions from the rectal mucosa often give rise to troublesome side-effects during and after radiotherapy in the pelvic region. Local vasoconstriction in the rectal mucosa will cause an ischemia which will decrease the sensitivity of the mucosal cells to radiation and thereby these side-effects can be reduced. Triglycyl-lysine-vasopressin applied rectally in 1% Blanose solution gave in the present study significant radioprotection of the rectal mucosa in the doses of 0.8, 1.6, and 3.2 mg. These doses are, however, very high. Triglycyl-lysine-vasopressin in 1.2% Natrosol solution in a dose of 128 micrograms did not show any certain protective effects. However lysine-vasopressin in 1.2% Natrosol solution in a dose of 16 micrograms gave significant radioprotection of the rectal mucosa. This dose level has in a previous study not given any significant effects on the systemic circulation. Lysine-vasopressin in Natrosol solution seems to be a suitable combination for further studies.

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The Protective Effect of Intra-Arterial Vasopressin Injections on the Small Bowel During Fractionated Abdominal Irradiation A study in pigs

Cited by 7 publications

References 9 publications

Radiation Enteritis

Radiation Enteritis

Radiation and the Small Intestine

Radioprotective Effect of Local Administration of Lysine-Vasopressin and Triglycyl-Lysine-Vasopressin on the Rectal Mucosa in Rats

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