Radiation-modified albumin in type 2 diabetic patients

Kalnina, Inta; Kirilova, Elena; Zvagule, Tija; Kurjane, Natalija; Šķesters, Andrejs; Silova, Alise; Gabruseva, Natalija; Gorbenko, Galina; Kirilov, G; Gonta, Svetlana

doi:10.5455/jeim.211012.or.049

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…Radiation effect [18][19][20][21] Around 6000 inhabitants (20-49 years old) of Latvia took part in clean-up works in Chernobyl in 1986-1991. Most of them were officially documented as recipients of ionizing radiation exposure 0-50 cGy.…”

Section: Non-malignant Diseasesmentioning

confidence: 99%

“…Measuring ABM characteristics in blood plasma could potentially be a useful tool to estimate the immune state of patients in clinical immunological screenings. [20,21] Alterations of Blood Plasma Albumin in Chernobyl Clean-up Workers with and without Type 2 Diabetes Mellitus. Diabetes mellitus has been one of the most crippling diseases that man has seen; and its the number of people suffering from it has risen dramatically over the past two decades.…”

Section: Non-malignant Diseasesmentioning

confidence: 99%

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Immune state of patients: detection using fluorescent response

Kalnina¹,

Kirilova²,

Gorbenko³

et al. 2014

J Autoimmun Cell Response

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An immune state of patient is the first question in medicine. The fluorescent probe offers clinicians a quick, reliable, and reproducible method. The material is presents findings of investigating the possibility of using the original fluorescent probe ABM (an aminoderivative of benzanthrone) for the detection of structural/functional alterations in blood plasma albumin and among immunocompetent cells in patients with different pathologies (non-malignant and malignant). We registered probe ABM spectral parameters in patients lymphocytes, blood plasma, and ABM auto-fluorescence in plasma. The fluorescence intensity of ABM in blood plasma and lymphocyte suspension differed from control values and showed specific differences in patient groups in accordance with immune status of patients. A significant decrease in ABM fluorescence in plasma could be explained, in part, by a diminished binding capacity of the albumin of these patients. The ABM fluorescence in cell suspension and blood plasma was found to correlate with select immunological parameters (CD4+/CD8+ ratious, lymphocyte counts, etc.). There was a strong agreement between changes in ABM spectral parameters and both clinical and pathological estimates of disease severity. Measures of ABM spectral characteristics could potentially be a useful tool to estimate the immune status of patients. Compared to many commonly used diagnostic protocols, the fluorescence based method is sensitive, less expensive and time consuming, technically simple and convenient.

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Section: Non-malignant Diseasesmentioning

confidence: 99%

Section: Non-malignant Diseasesmentioning

confidence: 99%

Immune state of patients: detection using fluorescent response

Kalnina¹,

Kirilova²,

Gorbenko³

et al. 2014

J Autoimmun Cell Response

Self Cite

View full text Add to dashboard Cite

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Investigations on Health Conditions of Chernobyl Nuclear Power Plant Accident Recovery Workers from Latvia in Late Period after Disaster

Reste

Zvagule

Kurjāne

et al. 2016

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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The paper summarises the main findings on Chernobyl Nuclear Power Plant (CNPP) accident recovery workers from Latvia and their health disturbances, which have been studied by the authors during the last two decades. Approximately 6000 persons from Latvia participated in CNPP clean-up works in 1986–1991. During their work period in Chernobyl they were exposed to external as well as to internal irradiation, but since their return to Latvia they were living in a relatively uncontaminated area. Regular careful medical examinations and clinical studies of CNPP clean-up workers have been conducted during the 25 years after disaster, gathering knowledge on radiation late effects. The aim of the present review is to summarise the most important information about Latvian CNPP clean-up worker health revealed by thorough follow-up and research conducted in the period of 25 years after the accident. This paper reviews data of the Latvian State Register of Persons Exposed to Radiation due to CNPP Accident and gives insight in main health effects found by the researchers from the Centre of Occupational and Radiological Medicine (Pauls Stradiņš Clinical University Hospital) and Rīga Stradiņš University in a number of epidemiological, clinical, biochemical, immunological, and physiological studies. Latvian research data on health condition of CNPP clean-up workers in the late period after disaster indicate that ionising radiation might cause premature ageing and severe polymorbidity in humans.

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Radiation-modified albumin in type 2 diabetic patients

Cited by 2 publications

References 14 publications

Immune state of patients: detection using fluorescent response

Immune state of patients: detection using fluorescent response

Investigations on Health Conditions of Chernobyl Nuclear Power Plant Accident Recovery Workers from Latvia in Late Period after Disaster

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