1958
DOI: 10.1126/science.128.3325.656
|View full text |Cite
|
Sign up to set email alerts
|

Radiation-Protective Effects of Yeast Extract and Yeast Ribonucleic Acid

Abstract: daloid regions are directed toward some integrative level of the brain, probably the hypothalamus, since Bard and Mountcastle (6) have demonstrated that the hypothalamus is a critical center for the integration of emotional display. Furthermore, hypothalamic connections have been established for both the septal and amygdaloid areas. It appears that, in the rat, the septal area may normally act to "dampen" the hypothalamic activity associated with emotional, states, while the amygdala may facilitate this dience… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
3
0

Year Published

1961
1961
2002
2002

Publication Types

Select...
4
3
1

Relationship

0
8

Authors

Journals

citations
Cited by 24 publications
(3 citation statements)
references
References 1 publication
0
3
0
Order By: Relevance
“…In recent years, however, postirradiation treatment with nucleic acid preparations was also reported to increase the survival rate of bacteria, rats, and mice given lethal dosages of X or gamma radiation (Cole and Ellis, 1955;Panjevac and Ristic, 1958). Detre and Finch (1958) have reported that a preirradiation injection of yeast extract or yeast ribonucleic acid (RNA) has a similar effect on rats and mice.…”
Section: Introductionmentioning
confidence: 99%
“…In recent years, however, postirradiation treatment with nucleic acid preparations was also reported to increase the survival rate of bacteria, rats, and mice given lethal dosages of X or gamma radiation (Cole and Ellis, 1955;Panjevac and Ristic, 1958). Detre and Finch (1958) have reported that a preirradiation injection of yeast extract or yeast ribonucleic acid (RNA) has a similar effect on rats and mice.…”
Section: Introductionmentioning
confidence: 99%
“…Later, we managed to protect mice from lethal doses of radiation with yeast RNA, a feat considered worthy of publication by the editors of Science in 1958. 1 When we showed our findings to radiology head Morton Kliegerman, he uttered 3 words: "Did you randomize?" We had not, but when we learned what randomization was and repeated our trial in a randomized fashion, we did not get the same results.…”
mentioning
confidence: 99%
“…Those observations indicated that irradiation has a stronger impact to inosine than hypoxanthine. It is known that the RNA isolated from yeast protects mice (Detre & Finch, 1958) and rats (Maisin, Dumont, & Dunjic, 1960) from radiation damage. Inosine has been used as a radioprotective medicine for patients treated by irradiation (Kamata, Haruyama, Okano, & Maruyama, 1968).…”
Section: Effect Of Irradiation On the Degradation Of Nucleotides In Rmentioning
confidence: 99%