Radiation sterilization of fluoroquinolones in solid state: Investigation of effect of gamma radiation and electron beam

Sterilisation of healthcare products by ionising radiation: sterilisation of drug-device products and tissue allografts

“…Typical losses, expressed as percentages, are 0.1% for thiamphenicol and 0.95% for fl orphenicol at the sterilisation dose of 25 kGy (Marciniec et al ., 2008(Marciniec et al ., , 2009a(Marciniec et al ., , 2009b(Marciniec et al ., , 2010. Similar studies have also been carried out on fl uoroquinolones and cephalosporins (Singh et al ., 2009(Singh et al ., , 2010. In all these studies, despite signifi cant differences in loss of drug, it was concluded that sterilisation doses of up to 25 kGy could be safely used.…”

Sterilization by gamma radiation of antibiotic impregnated polymethylmethacrylate and plaster of Paris beads

“…There may also be an inherent difference in the exposure to radiation of the enrofloxacin in POP versus PMMA. There are other matrices containing enrofloxacin that have been studied after radiation without showing the same effect, but this change requires further investigation looking for products of radiolysis (11). Further studies looking at the concentrations of enrofloxacin release from POP or PMMA beads as well as HPLC to look for products of radiolysis is indicated.…”

“…Radiation is an established and approved method of sterilization and has been studied with many different families of molecules. The effects of radiation on various medications have been studied including antibiotics, anti-protozoal and non-steroidal anti-inflammatory drugs which have all been successfully sterilized with gamma radiation (11)(12)(13). However radiation decreased the efficacy of the bronchodilator salbutamol and had variable effects on anticancer medications, depending on the level of radiation (14,15).…”

Uniform molecularly imprinted poly(methacrylic acid) nanospheres prepared by precipitation polymerization: the control of particle features suitable for sustained release of gatifloxacin

“…As mentioned above, MIP spheres could load more drug than NIP ones, so the release profiles of MIP 1 70(1/5) and NIP 1 70 were studied to find out whether drug release could also be affected by it. Since GFLX is photosensitive and easily decomposed in solution, 34 only records in the first 24 h were collected. As shown in Fig.…”