Radiation sterilization of pharmaceuticals and polymers

Gopal, N.G.S.

doi:10.1016/0146-5724(78)90072-9

Cited by 60 publications

(25 citation statements)

References 39 publications

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“…The dose that we have chosen in this work (25 kGy) is the one generally accepted as required for drug sterilisation. However, several pharmaceuticals can be sterilised using a lower dose (Jacobs and Wills, 1988;Dam et al, 1990;Whitby, 1993;Dam et al, 1996) which has the advantage of minimizing damage of the products (Gopal, 1978).…”

Section: Introductionmentioning

confidence: 99%

Role of residual solvents in the formation of volatile compounds after radiosterilisation of cefotaxime

Barbarin

Rollmann

Tilquin

1999

International Journal of Pharmaceutics

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Radiation sterilisation is a promising method to sterilise pharmaceutical products. However, this process is accompanied by a modification of odour due to volatile compounds formation. The origin of malodorous compounds produced during solid cefotaxime radiosterilisation has been investigated and several mechanisms are proposed to explain their appearance. Moreover, some quantitative data are given. Analysis of the degradation products was performed using a GC-ITD system with an injection by the static headspace technique. It appeared that some of the radio-induced compounds (such as carbon oxide sulfide and carbon disulfide) came from the degradation of the drug itself, whereas the formation of others required the presence of residual solvents which are volatile impurities already present before irradiation. Acetaldehyde directly came from impurities but the appearance of esters and acetaldehyde O-methyloxime was due to the presence of both cefotaxime and residual solvents together. Thus, the residual solvents play a key role in the radiolysis compounds formation (six of eight require the presence of them) and consequently in the modification of odour as well.

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Section: Introductionmentioning

confidence: 99%

Role of residual solvents in the formation of volatile compounds after radiosterilisation of cefotaxime

Barbarin

Rollmann

Tilquin

1999

International Journal of Pharmaceutics

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“…Ao irradiar um ser vivo, alguns elétrons possivelmente serão arrancados de átomos desses elementos. 16 Ao fornecer uma energia de radiação mais alta do que a energia que liga os elétrons aos átomos desses elementos, ocorre o processo chamado de ionização. A radiação que provoca ionização, denominada radiação ionizante, é mais prejudicial aos sistemas biológicos do que a radiação que não provoca ionização.…”

Section: Efeitos Dos Raios Gama Em Organismos Vivosunclassified

The Interaction of Gamma Radiation with the Matter in the Process of Sterilization

Silva¹,

Silva²,

Aquino³

2014

Revista Virtual De Química

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Abstract:The sterilization by gamma radiation is used as an international standard and its use has grown substantially in national processes. In this review, it is treated the interaction of ionizing radiation with matter and its effects, in addition to various applications of gamma irradiation as an effective tool for sterilization and decontamination of polymeric materials or reducing microbial load in food and packaging fields. This is a method that consists of exposing the products to the action of short electromagnetic waves generated from sources of Cobalt 60 and Cesium 137 in a specially prepared environment for this procedure. As electromagnetic waves have great penetrating power, organisms can be reached wherever they are, both in sealed packages as products packaged in the various forms, which ensures the overall effectiveness of the process.Keywords: Sterilization; Gamma radiation; Ionization; Interaction; Biological effect. ResumoA esterilização via radiação gama é utilizada como padrão internacional e o seu uso vem crescendo substancialmente nos processos nacionais. Nesta revisão será tratado o processo de interação da radiação ionizante com a matéria e seus efeitos, além das diversas aplicações de irradiação por raios gama como ferramenta eficiente para esterilização de materiais poliméricos e descontaminação ou redução de carga microbiana nos segmentos de alimentação e embalagens. Este é um método que consiste na exposição dos produtos à ação de ondas eletromagnéticas curtas, geradas a partir de fontes de Cobalto 60 e Césio 137 em um ambiente especialmente preparado para esse procedimento. Como as ondas eletromagnéticas possuem grande poder de penetração, os organismos podem ser alcançados onde quer que estejam, tanto em embalagens lacradas como em produtos acondicionados das mais variadas maneiras, o que garante a total eficácia do processo.

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“…Radiation sterilization is a well-established technique for large number of medical products (Gopal, 1978;Bhalla et al, 1985) but its potential is yet to be fully exploited. Adequate data is not available on radiation effects of many products, especially on parenteral drugs whose solutions are not stable and which are dispensed as sterile powders.…”

Section: Introductionmentioning

confidence: 99%

Radiation effect studies on anticancer drugs, cyclophosphamide and doxorubicin for radiation sterilization

Varshney

Dodke

2004

Radiation Physics and Chemistry

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Radiation sterilization of pharmaceuticals and polymers

Cited by 60 publications

References 39 publications

Role of residual solvents in the formation of volatile compounds after radiosterilisation of cefotaxime

Role of residual solvents in the formation of volatile compounds after radiosterilisation of cefotaxime

The Interaction of Gamma Radiation with the Matter in the Process of Sterilization

Radiation effect studies on anticancer drugs, cyclophosphamide and doxorubicin for radiation sterilization

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