Radiation therapy and conservation surgery for primary and recurrent carcinoma of the vulva: Report of 40 patients and a review of the literature

Wm, Pao; Ca, Perez; Rr, Kuske; Sommers, GM; Hm, Camel; Ae, Galakatos

doi:10.1016/0360-3016(88)90388-4

Cited by 26 publications

(6 citation statements)

References 25 publications

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“…In the present study the survival is similar stage for stage to that previously reported by both our institution and other institutions [3,6]. Pao et al reported [7]. Shimm et al, like us, reported that survival was significantly related to the stage of disease, the size of the tumor, and the lymph node status [8].…”

Section: Discussionsupporting

confidence: 90%

“…During this time period, 172 (85%) patients with squamous cell carcinoma of the vulva were evaluated. The other cell types included adenocarcinema (9), melanoma (8), Paget's disease (7), sarcoma (5), and basal cell (3 The malignancy was located on the right side in 49 patients (30%), was on left side in 42 patients (26%), and was bilateral in 71 patients (44%). The location of the lesion included labium minus, 30 (18%); labium majus, 49 (30%); perineum, 28 (17%); clitoris, 44 (27%); and entire vulva, 14 (8%).…”

Section: Resultsmentioning

confidence: 99%

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Squamous cell carcinoma of the vulva: Prognostic factors influencing survival

Hopkins

Reid

Vettrano

et al. 1991

Gynecologic Oncology

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One hundred seventy-two cases of patients with squamous cell cancer of the vulva treated at the University of Michigan Medical Center from 1975 to 1988 are reported. The mean age was 66 years with a range of 21 to 101 years. The distribution by stage included Stage I, 65; Stage II, 44; Stage III, 50; and Stage IV, 13 patients. Groin node dissections performed on 145 patients showed negative nodes, 58%; unilateral positive nodes, 28%; and bilateral positive nodes, 14%. The distribution of patients with positive nodes was influenced by stage: Stage I, 14%; Stage II, 23%; Stage III, 72%; Stage IV, 92%. The overall cumulative 5-year survival was 71% and this was significantly influenced by stage of disease: Stage I, 94%; Stage II, 91%; Stage III, 36%; Stage IV, 26%. Stages I/II and III/IV were combined for analysis. In Stages I/II, survival was significantly influenced by tumor grade while size, patient age, and lymph node status did not influence survival. In Stage III/IV, survival was significantly influenced by tumor size, node status, and number of positive nodes while grade, patient age, and tumor location did not influence survival. Squamous cell cancer of the vulva is effectively treated with radical surgery but advanced-stage disease with regional metastases significantly alters survival.

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Section: Discussionsupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Squamous cell carcinoma of the vulva: Prognostic factors influencing survival

Hopkins

Reid

Vettrano

et al. 1991

Gynecologic Oncology

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“…Irradiation alone is known to have a good palliative effect and can produce meaningful responses in the primary management of vulvar carcinoma either alone or in combination with systemic chemotherapy (14–16) . Recurrent tumors can be treated with some effectiveness with radiotherapy and in a small proportion salvage is possible (17) . In the past, radiotherapy was not advocated to treat vulvar cancer since the vulva and perineum were not considered to tolerate radiation well.…”

Section: Discussionmentioning

confidence: 99%

“…The main problem causing interruption in treatment was acute radiogenic reaction of the inguinal and perineal region, eg, moist desquamation with or without superinfections. Optimal skin care is therefore necessary to improve tolerance of radiotherapy and decrease the need for temporary interruptions of irradiation (17,19) .…”

Section: Discussionmentioning

confidence: 99%

Radiation treatment related factors influencing outcome in vulvar cancer patients

Warszawski

Suhr

Warszawski

et al. 2000

Int J Gynecol Cancer

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The objective of this research is to identify the impact of radiation treatment factors on survival in vulvar cancer patients. We performed a follow-up study on 60 women with squamous cell carcinoma of the vulva treated at the Department of Radiotherapy of the University of Ulm from 1980 to 1997. The follow-up time ranged from 0.5 to 17 years (mean 6.5 years). The irradiated volume included vulva and regional lymph nodes. The influence of treatment factors (tumor resection versus no tumor resection, treatment time, dose) on overall and disease-free survival was examined. In addition, applied doses were corrected for treatment time using the extended alpha/beta-model for calculating the biologically effective doses. The applied dose was 48.1 +/- 13.2 Gy (median: 50 Gy). Treatment time was 40.4 +/- 19.4 days (median: 38 days). 34/60 patients underwent surgery with complete resection of macroscopic tumor. 26 of 60 patients were resected incompletely or only a biopsy was taken. In univariate analysis prognostic factors influencing overall and disease-free survival were, along with T- and N-stage, treatment time, and biologically effective dose. In multivariate analysis, biologically effective dose was the only significant factor. We conclude that biologically effective dose and treatment time are important treatment factors influencing overall and disease-free survival vulvar cancer patients.

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“…226,227 No randomized data are available to evaluate the relative benefits and toxicities of interstitial versus external boost irradiation. 226,227 No randomized data are available to evaluate the relative benefits and toxicities of interstitial versus external boost irradiation.…”

Section: Preoperative or Definitive Vulvar Irradiationmentioning

confidence: 99%