Squamous cell carcinoma of the vulva: Prognostic factors influencing survival

Abstract

One hundred seventy-two cases of patients with squamous cell cancer of the vulva treated at the University of Michigan Medical Center from 1975 to 1988 are reported. The mean age was 66 years with a range of 21 to 101 years. The distribution by stage included Stage I, 65; Stage II, 44; Stage III, 50; and Stage IV, 13 patients. Groin node dissections performed on 145 patients showed negative nodes, 58%; unilateral positive nodes, 28%; and bilateral positive nodes, 14%. The distribution of patients with positive nodes was influenced by stage: Stage I, 14%; Stage II, 23%; Stage III, 72%; Stage IV, 92%. The overall cumulative 5-year survival was 71% and this was significantly influenced by stage of disease: Stage I, 94%; Stage II, 91%; Stage III, 36%; Stage IV, 26%. Stages I/II and III/IV were combined for analysis. In Stages I/II, survival was significantly influenced by tumor grade while size, patient age, and lymph node status did not influence survival. In Stage III/IV, survival was significantly influenced by tumor size, node status, and number of positive nodes while grade, patient age, and tumor location did not influence survival. Squamous cell cancer of the vulva is effectively treated with radical surgery but advanced-stage disease with regional metastases significantly alters survival.

Expression and prognostic relevance of endothelin-B receptor in vulvar cancer

“…The five-year overall survival rate is 68%. Survival worsens with an increase in tumour stage, age and nodal stage (8,9) all of which have been established as poor prognostic factors. In addition, molecular markers are needed to enable a better discrimination of more aggressive tumour phenotypes and to potentially facilitate a targeted molecular therapy in the future.…”

Prognostische Faktoren beim invasiven Plattenepithelkarzinom der Vulva

“…Die Korrelation zwischen dem klinischen In der vorliegenden Studie fanden wir keinen Signifika ten Einfluß des Lymphknotenstatus auf das Überleben. In der Literatur wird seine Wertigkeit nicht einheitlich beur teilt [3,5], Bedeutend für die Prognose der Patientinnen mit invasivem Vulvakarzinom waren in unserem Kranken gut und auch anderen Arbeiten das Alter [3] und der Um stand. ob eine Operation durchgeführt werden konnte oder nicht.…”

Serum concentrations of squamous-cell carcinoma antigen and tissue polypeptide antigen in the follow-up of patients with vulvar cancer

“…DISCUSSION Squamous-cell vulvar cancer is a rarely encountered disease, accounting for approximately 4% of all gynaecological malignancies. With appropriate management, patients with vulvar cancer have a 5-year survival rate of 60% to 70% (Hopkins et al, 1991;Hacker, 1994). Advanced-stage tumours develop recurrent disease after initial treatment in up to 70% of cases, with approximately equal distribution of local, regional and distant recurrent disease (Chan and Helm, 1996).…”