Radiation Therapy for Benign Disease

Eng, Tony Y.; Abugideiri, Mustafa; Chen, Tiffany; Madden, N.A.; Morgan, Tiffany; Tanenbaum, D.G.; Wandrey, Narine; Westergaard, Sarah A.; Xu, Karen; Sudmeier, Lisa

doi:10.1016/j.hoc.2019.09.006

Cited by 6 publications

(3 citation statements)

References 104 publications

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“…According to a meta-analysis, the recurrence rate of postexcisional radiotherapy can reach 22% ± 4%; our therapy's recurrence rate is up to 12.1%. [25][26][27] For patients concerned about the trauma and cost of traditional resections, CHN-Wu LCR may be more acceptable. It also may be more suitable than resection for patients with multiple keloids, because surgery usually cannot remove all the keloids at one time, and many keloids are unresectable.…”

Section: Plastic and Reconstructive Surgery • December 2023 1028ementioning

confidence: 99%

Laser combined with radiotherapy for keloid treatment: a novel and efficient comprehensive therapy with a lower recurrence rate

Yang

Chen

et al. 2023

Plastic &Amp; Reconstructive Surgery

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With keloids, a fibroproliferative skin disorder characterized by gradually spreading skin involvement, patients not only have cosmetic disfigurement and functional impairment but also psychological burden. Available treatments include intralesional corticosteroid or 5-fluorouracil injection, surgical excision, laser therapy, radiotherapy, pressure therapy, and application of silicone gel. Despite the variety of available treatment methods, the recurrence rate remains high. 1 Laser is a fast-growing treatment that has been used in keloid treatment since 1984. 2 Traditionally, nonablative and ablative lasers are used primarily for prevention and treatment. Nonablative lasers, such as pulsed dye lasers (PDL), can improve symptoms and appearance but have little effect on reducing volume. 3 Ablative laser devices, including CO 2 lasers and Er:YAG lasers, produce microthermal injuries on the skin; then, the process of fibroblast proliferation and collagen remodeling Background: Keloids are a fibroproliferative skin disorder with a high recurrence rate. Combined therapies are often used in clinical treatment, but, in addition to the relatively high risk of relapse and complexity of the treatment process, side effects remain unknown for combination therapies. Methods: A total of 99 patients with keloids in 131 positions were included in this retrospective study. Fractional CO 2 laser therapy was first applied with energy ranging from 360 to 1008 mJ; then, 6-Mev, 900-cGy electron beam irradiation was applied twice. The first pass was initiated within 24 hours after the laser therapy, and the second pass was performed on the seventh day after laser therapy. The Patient and Observer Scar Scale evaluated the lesions before the treatment and at 6, 12, and 18 months after treatment. At each follow-up visit, the patients filled out a questionnaire on recurrence, side effects, and satisfaction. Results: The authors found a significant decrease in total Patient and Observer Scar Scale score [29 (23, 39) versus 61.2 ± 13.4; P < 0.001] at the 18-month follow-up compared with the baseline value (before the therapy). A total of 12.1% of the patients had recurrences during the 18-month follow-up period (11.1% partial recurrence and 1.0% complete recurrence). The total satisfaction rate was 97.0%. No severe adverse effects were observed during the followup period. Conclusions: Laser combined with radiotherapy is a new comprehensive therapy comprising ablative lasers and radiotherapy for keloids. It had excellent clinical efficacy, low recurrence rate, and no serious adverse effects. (Plast.

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Section: Plastic and Reconstructive Surgery • December 2023 1028ementioning

confidence: 99%

Laser combined with radiotherapy for keloid treatment: a novel and efficient comprehensive therapy with a lower recurrence rate

Yang

Chen

et al. 2023

Plastic &Amp; Reconstructive Surgery

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“…Radiation therapy has usually been used in patients with OIP who are refractory, hormone-dependent, or intolerant to systemic glucocorticoid therapy. Commonly used radiation treatments include en face electron, intensity modulated radiation, and opposed lateral field three-dimensional conformal radiation [ 73 ].…”

Section: Treatmentmentioning

confidence: 99%

“…Side effects are less common in reports, mainly including cataracts, increased or decreased tear secretion, and photophobia [ 61 , 75 , 96 , 97 ]. Older patients with a complete response to radiation therapy had a lower recurrence rate of OIP [ 73 ]. The short-term effective rate of OIP radiotherapy is high and relatively safe, but the long-term control is not very satisfactory.…”

Section: Treatmentmentioning

confidence: 99%

Orbital inflammatory pseudotumor: new advances in diagnosis, pathogenesis, and treatment

Fang,

Shen,

Dai

et al. 2023

Eur J Med Res

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Orbital inflammatory pseudotumor (OIP) is a benign, non-specific inflammatory disorder that commonly occurs in middle-aged adults and is usually unilateral but can occur bilaterally. Its clinical manifestations have tremendous clinical heterogeneity and vary according to the site of infiltration and the degree of lesions, including orbital pain, swelling, diplopia, proptosis, restricted eye movement, and decreased visual acuity. Clinical features, Image characteristics and pathological examinations often need to be evaluated to confirm the diagnosis. Currently, there is no systematic research on the pathogenesis of OIP, which may be related to immunity or infection. The first-line treatment is glucocorticoids. Radiotherapy, immunosuppressants, and biologics can be considered for treatment-resistant, hormone-dependent, or intolerant patients. In this review, we aim to summarize and focus on new insights into OIP, including new diagnostic criteria, pathogenesis, and discoveries in new drugs and treatment strategies. In particular, we highlight the literature and find that T cell-mediated immune responses are closely related to the pathogenesis of OIP. Further exploration of the mechanism and signaling pathway of T cells in the immune process will help to identify their therapeutic targets and carry out targeted therapy to treat refractory OIP and reduce the side effects of traditional treatments.

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Is There Still a Role for Radiation Therapy in the Management of Benign Disease?

Fionda

Rembielak

2023

Clinical Oncology

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Radiation Therapy for Benign Disease

Cited by 6 publications

References 104 publications

Laser combined with radiotherapy for keloid treatment: a novel and efficient comprehensive therapy with a lower recurrence rate

Laser combined with radiotherapy for keloid treatment: a novel and efficient comprehensive therapy with a lower recurrence rate

Orbital inflammatory pseudotumor: new advances in diagnosis, pathogenesis, and treatment

Is There Still a Role for Radiation Therapy in the Management of Benign Disease?

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