Radiation therapy for non-aids associated (classic and endemic African) and epidemic Kaposi's sarcoma

Stein, Moshe; Lakier, R.; Spencer, David; Dale, Janet; Kuten, Abraham; MacPhail, Patrick; Bezwoda, W. R.

doi:10.1016/0360-3016(94)90186-4

Cited by 28 publications

(21 citation statements)

References 37 publications

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“…The total administered doses were similar to previously reported, typically curative due to the known radiosensitivity of the tumor. 14 Patient follow-up was 2 to 38 months. All patients were disease-free on last follow-up, except for the patient with the renal transplant who had suspicious areas on the right medial tibial surface, and remained on observation.…”

Section: Case Reportsmentioning

confidence: 99%

Non‐AIDS Kaposi's sarcoma in the head and neck area

et al. 2008

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Kaposi's sarcoma is classified into 4 types: classic (sporadic), African (endemic), iatrogenic (transplant recipients), and epidemic (acquired immunodeficiency syndrome [AIDS]-associated). This article aims to feature a comprehensive review of non-AIDS Kaposi's sarcoma, including literature review and report of 3 cases. Case material was from our hospital's archive. Literature review was conducted via electronic and manual medical database searches. Biological aspects, diagnostic difficulties, investigation protocols, and management modalities are discussed.

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Section: Case Reportsmentioning

confidence: 99%

Non‐AIDS Kaposi's sarcoma in the head and neck area

et al. 2008

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“…ICRT is not widely used outside Milan, and therefore our data are limited to a small number of patients recruited over a long period of time. The mean follow-up period is also short because of the natural history of HIV-KS 15,16 . We believe that wider availability of radiotherapy machines endowed with Chaoul tubes would be feasible owing to their relatively low costs, and would be useful in the treatment of oral HIV-KS with ICRT.…”

Section: Discussionmentioning

confidence: 98%

Intracavitary contact X-ray therapy of oral HIV-associated Kaposi's sarcoma

Caccialanza¹,

Piccinno²,

Gnecchi³

et al. 1997

Int J STD AIDS

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A retrospective study was performed to assess the efficacy and low mucosal toxicity of intracavitary contact X-ray therapy (ICRT), a proposed treatment of small/medium sized lesions of oral HIV-associated Kaposi's sarcoma (HIV-KS). Twenty-six patients with histologically confirmed oral HIV-KS underwent ICRT in the period 1986-1995. No patient received antiblastic or interferon therapy during the radiotherapy or follow-up periods. ICRT was performed according to the usual technical modalities of contact X-ray therapy, but the end of the source of ionizing radiations was introduced into the oral cavity. The total doses administered ranged from 10 to 50 Gy per field, in one or two weekly fractions of 5 Gy each. The follow-up ranged from 1 to 44 months (mean 7.5 months). Complete remission was obtained in 20 cases (76.92%), partial remission in 6 (23.08%) and relapse in one case (3.84%). Pain was relieved in all cases. Mucosal reaction was mild and did not result in any interruption of treatment. Our data suggest that ICRT is an effective and well tolerated treatment. It can be used in the management of oral HIV-KS instead of external radiotherapy, provided that the size and the location of the lesions and the conformation of the palate are suitable to this technique.

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“…Since KS is known to be a radiosensitive tumor, radiotherapy represents a very effective treatment strategy. Studies reveal that 90% of the lesions respond to radiotherapy, with approximately 70% showing a complete response [52]. Additional indications for radiation therapy are symptoms such as bleeding, lymphedema and palliation of pain.…”

Section: Kaposi's Sarcomamentioning

confidence: 98%