Radical degradation of High Molar Mass Hyaluronan Induced By ascorbate plus Cupric Lons testing Of arbutin in the function of Antioxidant

Valachová, Katarína; Rapta, Peter; Slovakova, M.; Priesolova, Elena; Nagy, Milan; Mislovičová, Danica; Dráfi, František; Bauerová, Katarína; _oltés, L

doi:10.1201/b14794-2

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Hyaluronan and Synovial Fluid1

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“…Acceleration of degradation of high-molecular-weight HA occurring under inflammation and/or oxidative stress is accompanied by impairment and loss of its viscoelastic properties (Parsons et al, 2002; Soltes et al, 2005; Stankovska et al, 2005; Lath et al, 2005; Hrabarova et al, 2007; Valachova & Soltes, 2010; Valachova et al, 2013a). Low-molecular weight HA was found to exert different biological activities compared to the native high-molecular-weight biopolymer.…”

Section: Hyaluronan and Synovial Fluidmentioning

confidence: 99%

Hyaluronan and synovial joint: function, distribution and healing

Tamer

2013

Interdisciplinary Toxicology

229

152

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Synovial fluid is a viscous solution found in the cavities of synovial joints. The principal role of synovial fluid is to reduce friction between the articular cartilages of synovial joints during movement. The presence of high molar mass hyaluronan (HA) in this fluid gives it the required viscosity for its function as lubricant solution. Inflammation oxidation stress enhances normal degradation of hyaluronan causing several diseases related to joints.This review describes hyaluronan properties and distribution, applications and its function in synovial joints, with short review for using thiol compounds as antioxidants preventing HA degradations under inflammation conditions.

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